Protein Alignment SLC2A3 and Glut3

DIOPT Version :9

• Sequence 1: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_536732.1
• Gene: Glut3 / 42036
• FlyBaseID: FBgn0015230
• Length: 507
• Species: Drosophila melanogaster
• Alignment Length: 465
• Identity: 120/465 - (25%)
• Similarity: 199/465 - (42%)
• Gaps: 47/465 - (10%)

Human     4 QKVTPALIFAITV-ATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSV 67
            ||:....::..|: :.||||.||...|.....|:.:.|      ....:..|:|:    .||...
  Fly    44 QKINNVGLYKATLYSNIGSFFFGIAVGWSGTAERSVME------QHSYSFQPTEL----QWSGVC 98

Human    68 AIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCG 132
            .:.::|..:....:||.|...|.|.::|| .||....|.|  |...|:||.||..||    .|.|
  Fly    99 ILLTLGAALWCLPMGLMVRLLGCRRTILI-QLLPNFLGWF--LTVFARSVPMLYAGR----FFLG 156

Human   133 LCTG----FVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTIL 193
            :|.|    .||:|..|||.|..|||.|.:.:...:.|::.:  |.:...|   ||  .::.|..|
  Fly   157 MCGGAHCVVVPIYNAEISTTKKRGAMGVVFEGACICGVIYS--FAMSLFL---EL--RIINFVNL 214

Human   194 PAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQ-DVSQDIQEMKDESARMSQEKQVTV 257
            ..:.........||||.: .::......|:..|:.|.|.: |..::|..:..:.....:|.:...
  Fly   215 GLLALGPLQILMPESPAY-YVDHGNIPRAEDSLRFLRGQKYDTRREIDFLTRDPTESEREVRQGP 278

Human   258 LELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVS 322
            |..|:....|:.:..|:.:.|.|:|.|.....:|...:.....::......:..|::  :..:..
  Fly   279 LLGFKYKKVRRSLARSLAIALLQKLCGALIFIFYGLNMLDCLRIRREFGLILCLGLI--LGFLAC 341

Human   323 LFLVERAGRRTLHMIGLGGMAFCS--------TLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEI 379
            .|||:|.|||.|.:....|:.|.|        ..||:.|.:      ||::.:..|.:||..:..
  Fly   342 FFLVDRLGRRPLLIFSSAGIVFVSIYLGLHFKVWMTMGLTV------MSWIALFCIAIFVGCYTA 400

Human   380 GPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLA 444
            |.|.:.|.:.|||..:..||...::....||.:.|.|...|.|.......|:|::|.......|.
  Fly   401 GVGSLTWVLNAELLVRPMRPLGCSIVCAFNWLTAFFVICWFGSHGVKCQPYLFLLFAIIASLILL 465

Human   445 FTFFKVPETR 454
            |:...:|||:
  Fly   466 FSLIYIPETK 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	118/457 (26%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)
		Monosaccharide binding. /evidence=ECO:0000269|PubMed:26176916	280..286		3/5 (60%)
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	117/449 (26%)
		MFS	63..>226	CDD:119392	52/186 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143938
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840