Protein Alignment SLC2A3 and CG31100

DIOPT Version :10

• Sequence 1: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_731299.1
• Gene: CG31100 / 41075
• FlyBaseID: FBgn0051100
• Length: 716
• Species: Drosophila melanogaster
• Alignment Length: 617
• Identity: 124/617 - (20%)
• Similarity: 206/617 - (33%)
• Gaps: 186/617 - (30%)

Human    13 AITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPS-EVLLTS---LWSLSVAIFSVG 73
            |:::..|..|.:|...|.   |..:|.....    .:|.:..| ::||..   .|..|:.:..|
  Fly    53 AVSIKNILLFGYGMTLGF---PTIVIPAIQG----GEGRSETSGDILLNKDEISWFSSINLICV- 109

Human    74 GMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFV 138
             .:|....||.....|:|.:|..|||..:....   :...|...|.|.....:.||..||....|
  Fly   110 -PLGCLFSGLLTQPLGKRRAMQFVNLPILAAWL---MFHFATRTEHLYAALCLAGLGGGLMEAPV 170

Human   139 PMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALP 203
            ..|:.||:....||....|....::.|:.:      :|||||...|..:...:....::....|.
  Fly   171 LTYVAEITEPKYRGILSALGTTCVITGVFI------QFILGSLMDWRSVAAVSSAFPVITIIMLC 229

Human   204 FCPESPRFLLINRKEEENAKQILQRLWG---TQDVSQDIQEMKDESARMSQEKQVTV-------- 257
            |.||||.:|:..::..|..|. ||.|.|   ...:..:..::.||   :..:|.:.:
  Fly   230 FVPESPVWLIREQRFREAVKS-LQWLRGWVPEHMIEAEFNQLYDE---LITQKAIELSADGIPPP 290

Human   258 ---------LELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPI---YATIG 310
                     |.::|..|:..|.::......:...||...:..|:..||..  ::.|:   :|||.
  Fly   291 GQRRTLGQRLRMWRKRSFLVPFLLVSFSFFTGHFSGKTPLQTYAVQIFHT--LKAPMNKYHATIL 353

Human   311 AGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFC------------------------------ 345
            .||...:.|::.:.|:...|:|.|.::...|...|
  Fly   354 LGVAEMLATILGVVLIHFTGKRPLVLVSTVGTGLCFFGTATYAHFLSEVPGFTVNNVVVNASSIM 418

Human   346 --------------------------------------STL----------------MTV----- 351
                                                  :||                ||.
  Fly   419 PKEGILSQQNISKIFETEQQAIRQETERFTTQLPDIETTTLFDQEIYNRSRRDVVEMMTTDAPMD 483

Human   352 --------------------------------SLLL---KDNYNGMSFVCIGAILVFVAFFEIGP 381
                                            .|||   |..:|.:.:|.:..:|:...|..:|.
  Fly   484 TTMWPEPSSSPEPIASSSLAPPSTSVKPPLVEELLLVVPKQEHNYLVWVPLILLLLSAFFSHLGI 548

Human   382 GPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVG---LLFPSAAHYLGAYVFIIFTGFLITFL 443
            ..:||.::.|:|....|.:|...||...:...||..   ||..||....|.:.|.....|..|.:
  Fly   549 RMLPWILIGEVFPAEIRNSASGFAGGVGYIFGFLANKLFLLMLSALTLPGTFAFYASVAFFGTVV 613

Human   444 AFTFFKVPETRGRTFEDITRAFEGQAHGADRS 475
              .:|.:|||.|||..:|      :||.:.:|
  Fly   614 --LYFTLPETEGRTLGEI------EAHFSKKS 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	117/596 (20%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)
CG31100	NP_731299.1	MFS	51..628	CDD:475125	120/600 (20%)