Protein Alignment SLC2A3 and CG1213

DIOPT Version :10

• Sequence 1: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_649599.1
• Gene: CG1213 / 40728
• FlyBaseID: FBgn0037387
• Length: 491
• Species: Drosophila melanogaster
• Alignment Length: 484
• Identity: 129/484 - (26%)
• Similarity: 214/484 - (44%)
• Gaps: 42/484 - (8%)

Human     1 MGTQKVTPALIF-AITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWS 64
            |..:.|....|| |...|.:.:|..|...|..:.....:|.      .|..::|.|..:.:...:
  Fly    32 MSPEPVKSGRIFMAAVAANLSAFVVGTTLGWTSPIGPKLKS------EDTSDSPLSRPITSDEDA 90

Human    65 LSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGL 129
            ...::.:||.::..|..|...:|.||:..:|..:|..|..   .||..||..|.:|.:.||:.|.
  Fly    91 WISSLIAVGALVAPFVAGPMADRIGRKWVLLSSSLFFVLA---FGLNMVASEVWILYMSRLIQGF 152

Human   130 FCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILP 194
            ..|......|||:||||...:|||.|:|.||.||.|||..      :.:|....:..|....|:.
  Fly   153 GVGFVMTVQPMYVGEISTDNVRGATGSLMQLFIVGGILYV------YAIGPYVSYQALQWCCIVV 211

Human   195 AILQSAALPFCPESPRFLLINRKEEENAKQIL----QRLWGTQDVSQDIQEMKDESARMSQEKQV 255
            .::........||||.|.....::.|..|.:.    |...|..|...:||...:|    :...:.
  Fly   212 PVVFDLVFYMMPESPYFFAGKGRKSEALKSLQFLRGQSAEGVHDEMAEIQANVEE----AMASKG 272

Human   256 TVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGV-QEPIYATIGAGVVNTIFT 319
            ||::||:.:..|:.:.|...|...|||||||.|.:.|..||..|.. .:|..|||..|.|....:
  Fly   273 TVMDLFKNAGNRRALFICAGLISFQQLSGINVVLFNSQSIFASANTGLDPAIATIIIGCVQVGSS 337

Human   320 VVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSL----------LLKDNYNGMSFVCIGAILVFV 374
            .::..:.:|.||:.:       :...|::|::.|          |:|.:.:.:.::.:.|::::.
  Fly   338 ALTPLVADRLGRKVM-------LLTSSSVMSIGLAALGAFFYMQLVKGDISSVVWMPVPALIIYN 395

Human   375 AFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFL 439
            ..:..|.||:||.::.|:|....:..|.:|...:.||..|||...:||.......|.|.:|...:
  Fly   396 IVYCTGFGPLPWAVLGEMFPANIKSVASSVVASTCWTLGFLVTFFYPSLDALGSYYAFWLFAVCM 460

Human   440 ITFLAFTFFKVPETRGRTFEDITRAFEGQ 468
            :....|..|.|.||:|.:.:.|.....|:
  Fly   461 VVAFFFVLFVVMETKGLSLQQIQDRLNGK 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	123/459 (27%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)
CG1213	NP_649599.1	MFS_GLUT6_8_Class3_like	43..481	CDD:340916	124/463 (27%)