Protein Alignment SLC2A3 and CG6484

DIOPT Version :10

• Sequence 1: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_611234.1
• Gene: CG6484 / 36994
• FlyBaseID: FBgn0034247
• Length: 465
• Species: Drosophila melanogaster
• Alignment Length: 482
• Identity: 161/482 - (33%)
• Similarity: 247/482 - (51%)
• Gaps: 44/482 - (9%)

Human     1 MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSL 65
            |....|.|..|..:: |:.|:...|.:.|..:..|.:|      |:..:...|.|    :|.:..
  Fly     1 MSKGSVLPQYIAGLS-ASFGALCMGASIGWSSPVENMI------TVNTEYGFPIS----SSQFGW 54

Human    66 SVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLF 130
            ..::.::|..:....:|..::..|||.:||.:....:.|...|   ..||:|.||..||.::|:.
  Fly    55 VSSLLTLGATVICIPIGFAIDWIGRRPTMLALIPPYMVGWVLM---LFAKNVTMLYFGRFILGMC 116

Human   131 CGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLL---LGFTI 192
            .|......|||..||:.|||||..|:..||.||.|:|...:.| .|:       |||   :...|
  Fly   117 GGAFCVTAPMYCTEITATALRGTIGSFFQLLIVSGVLYGYLVG-AFL-------PLLTINILCAI 173

Human   193 LPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQ-DVSQDIQEMKDESARMSQEKQVT 256
            ||.|...... |.||||.:|.:..:.::.|| .||.|.|.. |:..:::|:.:||.:.....||.
  Fly   174 LPVIFAIIHF-FMPESPVYLAMKGRNDDAAK-ALQWLRGKDADIDDELKEILEESQKQIDMPQVN 236

Human   257 VLELFRVSSYRQPII-----ISIVLQLSQQLSGINAVFYYSTGIFKDAGVQ-EPIYATIGAGVVN 315
            :|     ||.|:||:     |:::||:.||.:|||||.:||..||:|.|.. ....||:..||..
  Fly   237 IL-----SSLRRPIVLKGLGIAVLLQVFQQWTGINAVLFYSASIFEDTGSDISGSDATLIIGVTQ 296

Human   316 TIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDN----YNGMSFVCIGAILVFVAF 376
            ...|:|::.::::||||.|.:|....||..:.||.|...||:|    .:...::.|.:|.:|:.|
  Fly   297 VTSTLVAVAIIDKAGRRILLLISGVLMAVSTALMGVYFQLKENDPASMDNFGWLPISSICIFIIF 361

Human   377 FEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLG-AYVFIIFTGFLI 440
            |.||.||:||.::|||||:..:..|.::||.|||.|.|:|.||||.....:| ...|.|||...:
  Fly   362 FSIGFGPVPWLVMAELFSEDVKSVAGSIAGTSNWLSAFVVTLLFPILKSSIGPGPTFWIFTAIAV 426

Human   441 TFLAFTFFKVPETRGRTFEDITRAFEG 467
            ....::.|.||||:|:|..:|.....|
  Fly   427 IAFFYSLFFVPETKGKTIIEIQDLLSG 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	153/458 (33%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		1/1 (100%)
CG6484	NP_611234.1	MFS_GLUT6_8_Class3_like	10..446	CDD:340916	156/464 (34%)