Protein Alignment SLC2A3 and Tret1-1

DIOPT Version :10

• Sequence 1: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_610693.1
• Gene: Tret1-1 / 36248
• FlyBaseID: FBgn0050035
• Length: 857
• Species: Drosophila melanogaster
• Alignment Length: 514
• Identity: 147/514 - (28%)
• Similarity: 239/514 - (46%)
• Gaps: 81/514 - (15%)

Human    11 IFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGM 75
            :.|....::||...|: .....:|..:       ::||: |....|| .....|....|..:.|:
  Fly   397 VLAALSVSLGSLVVGF-VSAYTSPALV-------SMTDR-NITSFEV-TQDAGSWVGGIMPLAGL 451

Human    76 IGSFSVGLFVNRFGRRNSML------IVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLC 134
            .|..:.|..:...||||::|      ||:.|.:.       |.|  :|.|::.||.:.|...|:.
  Fly   452 AGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIA-------CAV--NVAMVLCGRFLAGFCVGIA 507

Human   135 TGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQS 199
            :..:|:|:||.....:||..|.|......:|||:.      |:.||...|.:|       |.| .
  Fly   508 SLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLC------FVAGSFMNWSML-------AFL-G 558

Human   200 AALP--------FCPESPRFLLINRKEEENAKQILQRLWGTQ-DVSQDIQE-MKDESARMSQEKQ 254
            ||||        ..||:||: .:.|..||.|::.|:.|.|.: ||..:::. |:.::....|..:
  Fly   559 AALPVPFLILMFLIPETPRW-FVGRGLEERARKALKWLRGKEADVEPELKGLMRSQADADRQASR 622

Human   255 VTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAG-VQEPIYATIGAGVVNTIF 318
            .|:|||.::::.: |:.||:.|...||.||||||.:|:..|||||| ..:....||..|:||.:.
  Fly   623 NTMLELLKLNNLK-PLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFLA 686

Human   319 TVVSLFLVERAGRRTLHMIG----------LGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVF 373
            |.:.:.|::||||:.|..:.          |||..:|.|       ...:.:.:.::.:...:::
  Fly   687 TFIGIVLIDRAGRKILLYVSDIAMVLTLFVLGGFFYCKT-------YGPDVSHLGWLPLTCFVIY 744

Human   374 VAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAY-VFIIFTG 437
            :..|.:|.|||||.::.|:.....|.:|.:||...||...|:|...|......:||: .|.:|..
  Fly   745 ILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGA 809

Human   438 FLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV 496
            .....|.|....||||:|:|.|||.|...|:           |..|:|:...|..:.|:
  Fly   810 ICFVGLFFVIIYVPETQGKTLEDIERKMMGR-----------VRRMSSVANIKPLSFNM 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	135/471 (29%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)
Tret1-1	NP_610693.1	MFS_GLUT6_8_Class3_like	397..832	CDD:340916	137/476 (29%)