Protein Alignment SLC2A3 and sut4

DIOPT Version :10

• Sequence 1: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_523675.1
• Gene: sut4 / 36055
• FlyBaseID: FBgn0028560
• Length: 444
• Species: Drosophila melanogaster
• Alignment Length: 466
• Identity: 152/466 - (32%)
• Similarity: 240/466 - (51%)
• Gaps: 62/466 - (13%)

Human    16 VATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFS 80
            :..:|:|..|...|.....|..:|.      ::..|..|.:    :.|.|..::.::|.......
  Fly    12 IGALGAFCLGAVIGWSGPVENEVKN------SNAYNFTPRQ----TEWGLVGSLMTLGAAFSCIP 66

Human    81 VGLFVNRFGRRNSMLIVNLLAVTGGCFMG--LCKVAKSVEMLILGRLVIGL----FCGLCTGFVP 139
            ||:.:.:.||:.:|||     :....|:|  |..:|..:.||:|||.|:|.    ||..|    |
  Fly    67 VGVLIGKIGRKTTMLI-----LLPPFFIGWLLILLASHIAMLLLGRFVVGFCGGAFCVTC----P 122

Human   140 MYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPF 204
            ||:.||:....||..|...||.||.|||.|.:.|     |..:.:...:...|||.|. ...:.|
  Fly   123 MYVTEIAQVQYRGTMGCFFQLLIVFGILYAFVVG-----GFVKTFYFNIACAILPVIF-FVLMIF 181

Human   205 CPESPRFLLINRKEEENAKQILQRLWGTQ-DVSQDIQEMKDESARMSQEK---------QVTVLE 259
            .||||.| |..:.:.|.|::.|:.|.|.. |||.:::||   ||...:||         ::|:..
  Fly   182 MPESPIF-LAQKGKAEKAEKSLKFLRGKDADVSGELKEM---SAEGQKEKASVGKILCRRITLKG 242

Human   260 LFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAG-VQEPIYATIGAGVVNTIFTVVSL 323
            ||          :||.|.|.||::||||:.:|||.||:.|| ..||..:||..|:|..|.|::|:
  Fly   243 LF----------LSIGLMLFQQMTGINAIIFYSTFIFETAGSTLEPRISTIIVGIVQAIATIISI 297

Human   324 FLVERAGRRTLHMIGLGGMAFCSTLMTV--SLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPW 386
            .::|:.||:.|.::....|...:.:|.:  .:|:|   :|:.::.:.|:.||:..|.:|.||:||
  Fly   298 LVIEKVGRKILLLVSACMMGISTLIMALYFGMLMK---SGVGWLALIAVCVFIIGFSLGFGPVPW 359

Human   387 FIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYV-FIIFTGFLITFLAFTFFKV 450
            .::||||::..:..|.::||.:||...|:|.||||.....:||.. |.||.||.:....|..|.:
  Fly   360 LMMAELFAEDVKALAGSIAGTTNWCFAFIVTLLFPVLNDIIGATACFAIFFGFAVAAFVFILFLI 424

Human   451 PETRGRTFEDI 461
            |||:|:|..:|
  Fly   425 PETKGKTLNEI 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	149/459 (32%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)
sut4	NP_523675.1	MFS_GLUT6_8_Class3_like	7..434	CDD:340916	151/463 (33%)