Protein Alignment WNK1 and GAL11

DIOPT Version :10

• Sequence 1: XP_011519299.1
• Gene: WNK1 / 65125
• HGNCID: 14540
• Length: 2795
• Species: Homo sapiens
• Sequence 2: NP_014591.1
• Gene: GAL11 / 854106
• SGDID: S000005411
• Length: 1081
• Species: Saccharomyces cerevisiae
• Alignment Length: 1024
• Identity: 187/1024 - (18%)
• Similarity: 320/1024 - (31%)
• Gaps: 303/1024 - (29%)

Human  1096 SPLFFCFPQGTTSQQVLTASFSSGGSALHPQAQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQ 1160
            :|..|...|....|||       .....:.|.|.|.|.|.....||          |||||.:.|
Yeast   125 NPQMFLNQQAQARQQV-------AQQLRNQQQQQQQQQQQQRRQLT----------PQQQQLVNQ 172

Human  1161 --TAP-PQQTVQ---------YSLSQTSTSSEATTAQPVSQPQAPQV------------LPQVSA 1201
              .|| |:|.:|         .:..|.:..::.....|.....|.:|            |.|..|
Yeast   173 MKVAPIPKQLLQRIPNIPPNINTWQQVTALAQQKLLTPQDMEAAKEVYKIHQQLLFKARLQQQQA 237

Human  1202 GKQLPVSQPVPTIQGEPQ-------IPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQI-P 1258
            ..|   :|......|.||       |.:..|..:.|.:|.|:..|:.|......:|.. ::|| .
Yeast   238 QAQ---AQANNNNNGLPQNGNINNNINIPQQQQMQPPNSSANNNPLQQQSSQNTVPNV-LNQINQ 298

Human  1259 ISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQL-PTLLQPVTQLPSQ 1322
            |.:|...                         .|....||........:|| .|:.:||.|  |.
Yeast   299 IFSPEEQ-------------------------RSLLQEAIETCKNFEKTQLGSTMTEPVKQ--SF 336

Human  1323 VHPQLLQPAVQSM-------------GIPANLGQAAEVPLSSGDVLYQGFPPRLPPQYPGDSNIA 1374
            :...:.|.|::.:             ...:||.:|..||:                      ||.
Yeast   337 IRKYINQKALRKIQALRDVKNNNNANNNGSNLQRAQNVPM----------------------NII 379

Human  1375 PSSNVASVCIHSTVLSPPMPTEVLATPGYFPTVVQPYVESNLLVPMGGVGGQVQVSQPGGSLAQA 1439
            ......:...:.|:.:.       |||.......|....|.|          .|:.|...:.|||
Yeast   380 QQQQQQNTNNNDTIATS-------ATPNAAAFSQQQNASSKL----------YQMQQQQQAQAQA 427

Human  1440 PTTSSQQAVLESTQGVSQVAPAEPVAVAQTQATQPTTLASSVDSAHSDVASGMSDGNENVPSSSG 1504
            ...:..||..::....:|.|.|:..|.||.|| |....|.:...|.:...:......::.||...
Yeast   428 QAQAQAQAQAQAQAQAAQAAQAQAQAQAQAQA-QAQAQAQAQAQAQAQAQAQAQAHAQHQPSQQP 491

Human  1505 RH--------EGRTTKRHYRKSVRSRSRHEKTSRPKLRILNVSNKGDRVVECQLETHNRKMVTFK 1561
            :.        .|.|......:.::..|.  ..|:..||:.:|:|        .|....::.:..|
Yeast   492 QQAQQQPNPLHGLTPTAKDVEVIKQLSL--DASKTNLRLTDVTN--------SLSNEEKEKIKMK 546

Human  1562 FDLDGDNPEEIATIMVNN---DFILAIERESFVDQ-------VREIIEKADEMLS---------- 1606
            .     ...:...:.|:|   ...:..:.|:|:.:       |:||:||..|.:.
Yeast   547 L-----KQGQKLFVQVSNFAPQVYIITKNENFLKEVFQLRIFVKEILEKCAEGIFVVKLDTVDRL 606

Human  1607 --------EDVSVEPEGDQGLESLQ----------GKDDYGFSGSQKLEGEFKQPIPASSMPQQI 1653
                    |.:.::....|.:...|          |....|.:.:...:...:|.:......||:
Yeast   607 IIKYQKYWESMRIQILRRQAILRQQQQMANNNGNPGTTSTGNNNNIATQQNMQQSLQQMQHLQQL 671

Human  1654 GIPTSSLTQVVHSAGRRFIVSPVPESRLRESKVFPSEITDTVA--ASTAQSPGMNLSHSASSLSL 1716
            .:......|......::      .:.:.::..::||. |..||  ::.|.:||.|:.:
Yeast   672 KMQQQQQQQQQQQQQQQ------QQQQQQQQHIYPSS-TPGVANYSAMANAPGNNIPY------- 722

Human  1717 QQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVP------PFLS-SIAGVPTTAAATAPVPATSS 1774
                        ....||:..:|.::....|.||      |.|: :|.|.......:..:|.||.
Yeast   723 ------------MNHKNTSSMDFLNSMENTPKVPVSAAATPSLNKTINGKVNGRTKSNTIPVTSI 775

Human  1775 PPNDISTSVIQSEVTVPTEEGIAGVATST--------GVVTSGGLPIP--------PVSESPVLS 1823
            |..:...|:..:....||....:..|.||        ...|..|.|.|        |:...|..:
Yeast   776 PSTNKKLSISNAASQQPTPRSASNTAKSTPNTNPSPLKTQTKNGTPNPNNMKTVQSPMGAQPSYN 840

Human  1824 SVV------------SSITI-------------------PAVVSISTTSPSLQVPTSTSEIVVSS 1857
            |.:            ..:.|                   |..:.:||....|.:  ...|::.|.
Yeast   841 SAIIENAFRKEELLLKDLEIRKLEISSRFKHRQEIFKDSPMDLFMSTLGDCLGI--KDEEMLTSC 903

Human  1858 TALYPSVTVSATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATL--TSVSTTTSFPSTASQLCI 1920
            |  .|...|...:.|        |.:.|...:|:|....::..::  ..:...:.|..:.....|
Yeast   904 T--IPKAVVDHINGS--------GKRKPTKAAQRARDQDSIDISIKDNKLVMKSKFNKSNRSYSI 958

Human  1921 QLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSLSAPSSSSSPGAG 1969
            .||   :...:.:.:..:...|....||         |:||:||:...|
Yeast   959 ALS---NVAAIFKGIGGNFKDLSTLVHS---------SSPSTSSNMDVG 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNK1	XP_011519299.1	STKc_WNK1	195..483	CDD:270932
		OSR1_C	500..563	CDD:463491
		PHA03247	<1178..1507	CDD:223021	69/370 (19%)
		PHA03247	<1986..2280	CDD:223021
GAL11	NP_014591.1	KIX_2	9..80	CDD:465331
		gal11_coact	170..232	CDD:418417	10/61 (16%)
		Med15_fungi	509..620	CDD:398846	19/125 (15%)