Protein Alignment WNK1 and wnk-1

DIOPT Version :10

• Sequence 1: XP_011519299.1
• Gene: WNK1 / 65125
• HGNCID: 14540
• Length: 2795
• Species: Homo sapiens
• Sequence 2: NP_001294032.1
• Gene: wnk-1 / 177743
• WormBaseID: WBGene00006941
• Length: 1850
• Species: Caenorhabditis elegans
• Alignment Length: 2144
• Identity: 588/2144 - (27%)
• Similarity: 843/2144 - (39%)
• Gaps: 682/2144 - (31%)

Human    20 PPAPAPKNGSSSDSSVG---------------EKLGAAAADAVTGR---TEEYRRRRHTMDKD-- 64
            ||||.....|::.|:.|               ::|..|..:...|.   :|:.|.|...:.:|
 Worm    11 PPAPPSSVSSTTASTTGNFGTRRRLVNRIKKVDELHPAQENPTMGSHWLSEQERSRLEAVQQDWR 75

Human    65 ----------SRGAAATTTTTEHRFFRRSVICDSNATALELPGL--PLSLPQPSIPAAVPQSAPP 117
                      |:......||:.     .|.:..|||.....|.|  ..|:...|.|.::..:|
 Worm    76 RTRPMKFQWTSKKRPDDPTTSS-----PSTVSISNALENSTPSLNNVSSITNSSSPFSLSSAA-- 133

Human   118 EPHREETVTATA----TSQVAQQPP--------------------------------AAAAPGEQ 146
                  |.||:|    ||.||...|                                |||.|...
 Worm   134 ------TSTASAIIPFTSNVATNHPHLNHHVSRIPQAIVTGGTNGSLPPLLISPTSAAAATPLIS 192

Human   147 AVAGP-APST------------------------------VPSSTS------------KDRPVSQ 168
            ..||| :|||                              :|.:||            .|:|:.|
 Worm   193 GKAGPMSPSTGSPINVAATVLQNAVSSPQHSIFDRSRLNKIPPNTSLASSSSPSDAANNDKPIQQ 257

Human   169 PSLVGSK---------EEPPPARSG-------SGGGSAKEPQEERSQQQD-----DIE---ELET 209
            ...:.|.         .:.|...:|       |....|::.||:|.:::.     |:|   :.:.
 Worm   258 RHSILSNVRTLTQAMVNDGPRTLTGDDMDKMVSEEERARKEQEKREEEEKAARRIDVEDDFDAQE 322

Human   210 KAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKG 274
            |.:..|.:|||||||.|:||||||||::||||||.|.|||||||:.||.|:|||||:|||||||.
 Worm   323 KPIDKSKNGRFLKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQRFREEAEMLKD 387

Human   275 LQHPNIVRFYDSWEST-VKGK-KCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQF 337
            |||||||||||.|||. :.|| |.||||||||||||||.||||||.:.||||:||||||||||.|
 Worm   388 LQHPNIVRFYDYWESADLCGKRKYIVLVTELMTSGTLKMYLKRFKRINIKVLKSWCRQILKGLSF 452

Human   338 LHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDES 402
            ||||.||:||||||||||||||.|||||||||||||||..||||||||||||||||||||.||||
 Worm   453 LHTRNPPVIHRDLKCDNIFITGTTGSVKIGDLGLATLKNKSFAKSVIGTPEFMAPEMYEEMYDES 517

Human   403 VDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKV--AIPEVKEIIEGCIRQNKD 465
            |||||||||:|||.|.|||||||.|.|.|||:|.|||||..|.::  ..||::|||:.|||..::
 Worm   518 VDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRRE 582

Human   466 ERYSIKDLLNHAFFQEE--TGVRVELAEED---DGEKIAIKLWLRIEDIKKLKG-KYKDNEAIEF 524
            ||.::|.||...||..|  .|:|||:...|   :...:.|::.||:.|.||.|. ::|:||.::|
 Worm   583 ERSTVKQLLVDDFFTPEDLIGIRVEIKNRDADLNDLNVEIQMQLRVYDEKKRKQYRFKENEGLQF 647

Human   525 SFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSL-----------IKRKREQRQLVREE 578
            :||:|.|.|::|.|:|:|..::.:.|.:.:.|.|||:|..           |||.:|:.:.:|||
 Worm   648 AFDIENDSPDEVVQQMIEQQHIPDEDTRMITKLIKDKVDAFRRDRDHRLLEIKRAKEEEERIREE 712

Human   579 QE-----------KKKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEP 632
            .|           |:|::|...|:::|:.:|:.......|   |.||....|..| |.|.:|..|
 Worm   713 AEIKEELRLRAEAKEKEKERLEKERLEKKAAAAAAANPNP---TPIPPTPATPHS-SAQQQPIPP 773

Human   633 ----EADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGSQHEQAHSTGTVPGH 693
                :.....|...||||:.|                                       |:..:
 Worm   774 PLSTQTSAEIQQSAQQPSVPV---------------------------------------TMIAN 799

Human   694 IPSTVQAQSQPHGVYPPSS----VPQSMAHPCGGTPTYPESQIFFPTIHERPVSFS--PPPTCPP 752
            ||:.....:||..|..|:|    ||.:|.|    .|...|..:........||:.:  ||...|.
 Worm   800 IPAMSPTSAQPQPVLSPTSAAVPVPTTMIH----VPKPSEIPVQNVATTAAPVAANNVPPSPAPF 860

Human   753 KVAISQRRKSTSFLEAQTHHFQPLLRTVG-----------QSLLPPGGSPTNW------------ 794
            |         |..::..|.....:.||:.           .|:..|..:|:..
 Worm   861 K---------TEDIQTPTLAQNTVPRTISTDASGLVINTPASIASPSPAPSATDVASTTAPVTPA 916

Human   795 -TPEAVVMLGTTASRVTGE-----------------------------SCEIQVHPMFEPSQVYS 829
             ||......|..|:..|.|                             ||.:..    ....|..
 Worm   917 PTPTTTTDGGAAAASTTTENKEEKRKSNKRKVVMEILGCDESRNFALVSCRLDT----SHKSVTF 977

Human   830 DYRPGLVLP-EEAHYFIPQEAVYVAGVHYQARVAEQYEGIPYNSSVLSSPMKQIPEQKPVQGGPT 893
            .:.||...| ..|...:.::.:....||
 Worm   978 QFAPGTDKPCTIATKLLAEDCLLKVHVH------------------------------------- 1005

Human   894 SSSVFEFPSGQAFLVGHLQNLRLDSGLGPGSPLSSISAPISTDATRLKFHPVFVPHSAPAVLTHN 958
               :.|...|:.     :|.:..|...|.|:.|:::..|.||:           |.:..||:..:
 Worm  1006 ---IVEAQLGEV-----IQLINSDGKKGVGTKLATVLDPNSTE-----------PPTITAVMPKD 1051

Human   959 NESRSNCVFEFHVHTPSSSSGEGGGILPQRVYRNRQVAVDLNQEELPPQSVGLHGYLQPVTEEKH 1023
                             ||:.......|:..........|.:||   |.:|.:.. ::.|::|.:
 Worm  1052 -----------------SSAATASNTKPKIEIEKTPPTRDASQE---PNNVQVTN-VRKVSQESN 1095

Human  1024 NYHAPELTVSVVEPIGQNWPIGSPEYSSDSSQITSSDPSDFQSPPPTGGA--------------- 1073
                .|...|:..|.|  ..:.||...:||            :|||||.|
 Worm  1096 ----AESVQSIPRPGG--IIVMSPTNQTDS------------APPPTGAAAKPSRFQVTKSADPI 1142

Human  1074 AAPFGSDVSMPFIHLPQTVLQESPLFFCFPQGTTSQQVLTASFSSGGSALHPQAQGQSQGQP-SS 1137
            |.|..|.:|      ..||:   |:....|...||:.|:.                    || ::
 Worm  1143 ATPISSSIS------TATVI---PIVAATPTNITSEPVIV--------------------QPITA 1178

Human  1138 SSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQ----TSTSSEATTAQPVSQ--------- 1189
            ..:|.:::..|:.|     .:...:.|..|...::|.    ||......|.|||||
 Worm  1179 QVITHLATPSPVSH-----SLSSNSSPSATTHSNMSSIQSTTSVPGRRFTVQPVSQAESGISSSI 1238

Human  1190 ---------------PQAPQVLPQVSAG--------KQLP--VSQPVPTIQGEPQIPVATQPSVV 1229
                           |..|.|.|.||.|        ||.|  .:|.|.|.........||..|..
 Worm  1239 STPHPEPTPAITSCPPPVPSVPPVVSNGTLNLEVAPKQTPSATNQNVDTQHSSSTASTATLVSET 1303

Human  1230 PVHSGAHFLPVGQPLPT--PLL-----------------------------PQYPVSQIPISTPH 1263
            |  :..|..|:..|.|.  ||:                             |...|..:...||
 Worm  1304 P--ATVHVTPISVPAPVQEPLVIDHHSDVLTQLDSELRKCFQVSGVSHSASPSTVVESLTSMTP- 1365

Human  1264 VSTAQTGFSSLPI---TMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHP 1325
                    .::|:   |:.|.|.|....:|::...:.||..|  || |.|:.|...|.| :.:|.
 Worm  1366 --------QTIPLACQTVPASIGQAPAVIAAAHAASLIPNAS--VP-QSPSRLDAETGL-AGLHE 1418

Human  1326 QL-----LQPAVQSMGIPANLGQAA-----EVPLSS--------GDVLY----QGFPPRLPPQYP 1368
            :|     .|...:.||..| :|...     |:|:.:        |.|::    :..|  :||.:|
 Worm  1419 KLEALKMEQDRREDMGDDA-IGTTTTDGKDEIPIDTLKGLAEALGKVIHADGRETTP--MPPDHP 1480

Human  1369 GDSNIAPSSNVASVCIHSTVLSPPMPTEVLATPGYFPTVVQPYVESNLL----VPMGGVGGQVQV 1429
               ::..:|.       ..::||..| :||.|   ..:.|:....|.::    .....|...:..
 Worm  1481 ---DLTDAST-------QQLISPSNP-DVLTT---MSSAVEGSASSTMIEDIDASTSAVDASMMN 1531

Human  1430 SQPGGSLAQAPTTSSQQAVLESTQGVSQVAPAEPVAVAQTQATQPTTLAS--SVDSAHSDVASGM 1492
            |.|.|:     ..|:.|.....|..:.|.. |:.:..:.|:.|..|.||:  ::::|.|... |.
 Worm  1532 SMPPGA-----QNSTDQIPAAMTLSMDQEC-AQSMTSSITRNTTGTKLATFENLETALSSTL-GT 1589

Human  1493 SDGNENVPSSSGRHEGRTTKRHYRKSVRSRSRHEKTS----RPKLRILNVSNKGDRVVECQLETH 1553
            .....|.|||........|.....:.:........||    .|.      |:....|.||..:..
 Worm  1590 HIRQPNAPSSRDETTAPMTPSFTNERIGGGGGGGATSFSIGTPP------SHSPFPVSECDYDLK 1648

Human  1554 NRKMVTFKFDLDGDNPEEIATIMVNNDFILAIERESFVDQVREIIEKADEML--SEDVSVEPE-- 1614
            .      :.||:.::||.|..|:.:.     :|:...:::.|..||:....:  ....||.||
 Worm  1649 G------QMDLESEDPEVIQMIVRHR-----MEQHKLLEKQRVEIERLRSKIRVPRATSVNPEMI 1702

Human  1615 GDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQ----------------IGIPTSSLTQV 1663
            ||.       :.|...:..|...|.....:|||..|..                ||.|..::: :
 Worm  1703 GDD-------EADTTLTALQSALGNASLSLPASPPPNTEIPDNEGQHHCNSFRCIGDPNDNVS-I 1759

Human  1664 VHSAGRRFIVSPVPESRLRESKVFPSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQM 1728
            |:...:|..:  :|.||            .:|.::|:.||....|.|
 Worm  1760 VNQIKQRLGI--IPSSR------------QSVRSATSSSPSTPPSSS------------------ 1792

Human  1729 TEGPNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAA------TAPVPATSSPPNDISTSVIQS 1786
                 :|||. |.:.||...|.....|| |..:||::      .:|...|||..:|.:|.||::
 Worm  1793 -----SAPPK-SLSSPTKSYVSHCSLSI-GYGSTASSEQQQREPSPSATTSSFLSDPATGVIEN 1849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WNK1	XP_011519299.1	STKc_WNK1	195..483	CDD:270932	210/301 (70%)
		OSR1_C	500..563	CDD:463491	25/63 (40%)
		PHA03247	<1178..1507	CDD:223021	94/424 (22%)
		PHA03247	<1986..2280	CDD:223021
wnk-1	NP_001294032.1	STKc_WNK	332..596	CDD:270885	200/263 (76%)
		OSR1_C	622..686	CDD:463491	25/63 (40%)