Protein Alignment BMP3 and Actbeta

DIOPT Version :10

• Sequence 1: NP_001192.4
• Gene: BMP3 / 651
• HGNCID: 1070
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Alignment Length: 338
• Identity: 81/338 - (23%)
• Similarity: 128/338 - (37%)
• Gaps: 100/338 - (29%)

Human   160 HIQIDL--SAWTLKF-SRNQSQLLG-HLSVDMAKSHRDIMSWLSKDITQLLRKAKENEEFLIGFN 220
            ||:||.  |.|..|. |..:..||. .......|.|..|..|:.:..|.:              |
  Fly   682 HIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSI--------------N 732

Human   221 ITSKGRQLPKRRLPFPEPYILVYANDAAI-------SEPESVVSSLQGHRNFP-TGTVPKW---D 274
            ||.||                   .|.||       .:|:::     |.:.|. |.|:.:|   .
  Fly   733 ITEKG-------------------IDKAIIFRASFQVDPKNL-----GWQKFDLTDTIREWYGHT 773

Human   275 SHIRAALSIERRKKRSTGV-----LLPLQNNELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKN 334
            ||.:..|.|:     .||.     |...|.::|.|....|...   ...:|:..|..   |.|:.
  Fly   774 SHEKLRLLID-----CTGCGGRYSLHLFQTSKLRGNSSDYLST---NPNRPFLVLHT---ESSRT 827

Human   335 KKKQRK----GPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFD 395
            ::.:|:    |.....|                      |.:....|.|..:||.:|||:|:.:.
  Fly   828 RRVRRRAVDCGGALNGQ----------------------CCKESFYVSFKALGWDDWIIAPRGYF 870

Human   396 AYYCSGAC--QFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVL 458
            |.||.|.|  .|..|.:.: :.||......|.:|::.|: .|||.|.|.||:|::::.:: .::.
  Fly   871 ANYCRGDCTGSFRTPDTFQ-TFHAHFIEEYRKMGLMNGM-RPCCAPIKFSSMSLIYYGDD-GIIK 932

Human   459 KVYPNMTVESCAC 471
            :..|.|.|:.|.|
  Fly   933 RDLPKMVVDECGC 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP3	NP_001192.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..53
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..350		7/33 (21%)
		TGF_beta_BMP3	363..472	CDD:381663	34/111 (31%)
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	33/102 (32%)