Protein Alignment BMP3 and myo

DIOPT Version :10

• Sequence 1: NP_001192.4
• Gene: BMP3 / 651
• HGNCID: 1070
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Alignment Length: 522
• Identity: 118/522 - (22%)
• Similarity: 181/522 - (34%)
• Gaps: 178/522 - (34%)

Human    46 PDSELQPQDKVSEHMLRLYDRYSTVQAA----RTPGSLEGGSQPWRPRLLREGNTVRSFRAAAAE 106
            |..:..|..|||||     ...|.||:.    .|..::|...|    |.|||        .|..:
  Fly   158 PGKKSTPLAKVSEH-----GDLSRVQSVSLYRNTLINIESMLQ----RQLRE--------KAKVD 205

Human   107 TLERKGLYIFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQIDLSAWTLK 171
            ::|...::|....:|.|..||..             .:|.|     .:.....:...:.|:.|..
  Fly   206 SIESIKMHILMRLNLKKLPNITK-------------PISVP-----QNIIDNFYRDYNASSKTTV 252

Human   172 FSRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQLLRKAKEN--EEFLIGFNITSKGRQLPKRRLP 234
            ::|.:|....|||::.......:..:..:..:..::....|  .||||..|    ..|..|..:|
  Fly   253 WNRMESIDESHLSINDTYGDHIMTDFFDESSSSQMQGDDANTVNEFLIDLN----KNQAKKSDIP 313

Human   235 FPEPYILVYANDAAISEPESVVSSLQGHRNFPTGTVP---------------------------- 271
                   :..||   .|.||::|.:.....||....|
  Fly   314 -------INTND---EEYESILSHISSIYIFPEEIQPHVRHNRKVDVFRFQIDSSYSDLSYATLH 368

Human   272 ------KWDSHIRAALSIERRKKRSTGVLLPLQ--------------------NNELPGA----- 305
                  .|.|..:..|..|.:|:....:::.:.                    .:.:|..
  Fly   369 LYLRGWDWISAHQPGLLEEIKKQPRKDIVVTIHRAIRVANTTSFNPKVKMFEFRHSIPSGLGQWV 433

Human   306 -----------------EYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDE 353
                             |...|..|.|     .|:|.......|||           ..|:..:.
  Fly   434 AVDLKSLLGNLGSNMTQEILIKGAETW-----MKSLVVTTDNTSKN-----------PLTVHIEI 482

Human   354 QTLKKARRKQWI--------EPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGAC------Q 404
            .:.||.|||:.:        ....|.|..|||:|...|| .::::|.|||||:|||.|      |
  Fly   483 GSQKKHRRKRSVYMDCTENDHDMRCCRYPLKVNFTSFGW-HFVVAPTSFDAYFCSGDCKVGYLEQ 546

Human   405 FPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESC 469
            :|         |..:.::..:.       .|||.|.||||||:|:||:|.|:||.|.|||:||.|
  Fly   547 YP---------HTHLAALTTSA-------TPCCSPTKMSSLSLLYFDDNHNLVLSVIPNMSVEGC 595

Human   470 AC 471
            :|
  Fly   596 SC 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP3	NP_001192.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..53		1/6 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..350		6/29 (21%)
		TGF_beta_BMP3	363..472	CDD:381663	46/123 (37%)
myo	NP_726604.1	TGF_beta_GDF8_like	506..597	CDD:381629	45/107 (42%)