DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JMJD4 and Jmjd4

DIOPT Version :9

Sequence 1:	NP_075383.3	Gene:	JMJD4 / 65094	HGNCID:	25724	Length:	417	Species:	Homo sapiens
Sequence 2:	NP_848774.1	Gene:	Jmjd4 / 194952	MGIID:	2144404	Length:	427	Species:	Mus musculus

Alignment Length:	426	Identity:	318/426 - (74%)
Similarity:	355/426 - (83%)	Gaps:	10/426 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDRETRALADSHFRGLGVDVP--GVGQAPGRVAFVSEPGAFSYADFVRGFLLPNLPCVFSSAFTQ 63
            ||||||..|:.::|.|...||  |.|..|..|.|:..|.||||||||:||||||||||||||||:
Mouse     1 MDRETRTFAERYYRDLRDPVPSGGGGPTPSGVTFIQTPNAFSYADFVKGFLLPNLPCVFSSAFTE 65

Human    64 GWGSRRRWVTPAGRPDFDHLLRTYGDVVVPVANCGVQEYNSNPKEHMTLRDYITYWKEYIQAGYS 128
            ||||||||||..|:|||::|.:.|||.|||||||||:||||||||||:.||||:|||:|||..||
Mouse    66 GWGSRRRWVTSEGKPDFEYLQQKYGDAVVPVANCGVREYNSNPKEHMSFRDYISYWKDYIQGSYS 130

Human   129 SPRGCLYLKDWHLCRDFPV---EDVFTLPVYFSSDWLNEFWDALDVDDYRFVYAGPAGSWSPFHA 190
            |.||||||||||||||..|   ||:|||||||||||||||||.|:|||||||||||.|:||||||
Mouse   131 SSRGCLYLKDWHLCRDSLVNDLEDIFTLPVYFSSDWLNEFWDVLNVDDYRFVYAGPRGTWSPFHA 195

Human   191 DIFRSFSWSVNVCGRKKWLLFPPGQEEALRDRHGNLPYDVTSPALCDTHLHPRNQLAGPPLEITQ 255
            |||||||||||:||:||||.||||:||||||.||||||||||..|.||||:|:.|....|:|:.|
Mouse   196 DIFRSFSWSVNICGKKKWLFFPPGEEEALRDCHGNLPYDVTSTELLDTHLYPKIQHHSLPIEVIQ 260

Human   256 EAGEMVFVPSGWHHQVHNLDDTISINHNWVNGFNLANMWRFLQQELCAVQEEVSEWRDSMPDWHH 320
            |.||||||||||||||:|||||||||||||||.||.|||.||||||.|||.||.||:||||||||
Mouse   261 EPGEMVFVPSGWHHQVYNLDDTISINHNWVNGCNLPNMWHFLQQELQAVQHEVEEWKDSMPDWHH 325

Human   321 HCQVIMRSCSGINFEEFYHFLKVIAEKRLLVLREAAAEDGA-----GLGFEQAAFDVGRITEVLA 380
            ||||||:||:||||||||||||||||||||||.:....|..     .||.:|||||:||:.:|||
Mouse   326 HCQVIMKSCTGINFEEFYHFLKVIAEKRLLVLEQGLKGDSGDSRSLDLGLQQAAFDIGRLADVLA 390

Human   381 SLVAHPDFQRVDTSAFSPQPKELLQQLREAVDAAAA 416
            |:|.:|||||||||||||||:||||||.:||.||.|
Mouse   391 SVVVNPDFQRVDTSAFSPQPEELLQQLEDAVAAAEA 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JMJD4	NP_075383.3	cupin_RmlC-like	42..288	CDD:424065	199/248 (80%)
Jmjd4	NP_848774.1	cupin_like	38..289	CDD:304367	200/250 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83954640
Domainoid	1	1.000	248	1.000	Domainoid score	I20053
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11306
Inparanoid	1	1.050	679	1.000	Inparanoid score	I9511
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG60265
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006315
OrthoInspector	1	1.000	-	-		oto115089
orthoMCL	1	0.900	-	-		OOG6_104551
Panther	1	1.100	-	-	LDO	PTHR12480
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R627
SonicParanoid	1	1.000	-	-		X4599
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.430