Protein Alignment SLC4A3 and Ndae1

DIOPT Version :9

• Sequence 1: NP_001313488.2
• Gene: SLC4A3 / 6508
• HGNCID: 11029
• Length: 1259
• Species: Homo sapiens
• Sequence 2: NP_723263.2
• Gene: Ndae1 / 34005
• FlyBaseID: FBgn0259111
• Length: 1190
• Species: Drosophila melanogaster
• Alignment Length: 1284
• Identity: 415/1284 - (32%)
• Similarity: 601/1284 - (46%)
• Gaps: 309/1284 - (24%)

Human    37 DLGKTLAVSRFGDLISKPPAWDPEKPSRSYSERDFEFHR-HTSHHTHHPLSARLPPPHKLRRLPP 100
            :|..|:..|...|...|.|....|..::.::|.|||.|| ||.:...|               .|
  Fly     9 ELPWTMNSSSGDDEAPKDPRTGGEDFTQQFTENDFEGHRAHTVYVGVH---------------VP 58

Human   101 TSARHTRRKRKKEKTSAPPS-----------EGTPPIQEEGGAGVDEEEEEEEEEEGESEAEPVE 154
            ...||::|:||... |.|..           .|:..:  .||||.|...|:::|.|     .||.
  Fly    59 GGRRHSQRRRKHHH-SGPGGGGGGGGGGGSIGGSGSV--GGGAGKDNVSEKQQEVE-----RPVT 115

Human   155 PPHSGTPQKAKFSIGSDEDDSPGLPGRAAVTKPLPSVGPHTDKSPQHSSRPCSELRDGDGTTDLA 219
            ||    .|:.:|.:|.|.||                 |.|..
  Fly   116 PP----AQRVQFILGEDVDD-----------------GTHVS----------------------- 136

Human   220 LSSPRLLCCLPSSPSPRARASRLAGEKSRPWSPSASYDLRERLCPGSALGNPGGPEQQVPTDEAE 284
                                                                             
  Fly   137 ----------------------------------------------------------------- 136

Human   285 AQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRKKKKKKLDRRPHEVF 349
                                                                         |.:|
  Fly   137 -------------------------------------------------------------HPLF 140

Human   350 VELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGAALLDL 414
            .|:. :::....|..|:||||||||||||||...||.|||||:||..||.||||.:.:|:.:||:
  Fly   141 SEMG-MLVKEGDEIEWKETARWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRRLLVNGSVMLDM 204

Human   415 EQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFP--------RNPSSS 471
            |...|..:|.||.:.|:.:..:.|..:..|...||.:|.|.::.......|        ||.|||
  Fly   205 EAQNLEVMADLVCDHMVSAGTLPPGVKDKVKDALLRRHRHQHEYAKKTRLPIIRSLADMRNHSSS 269

Human   472 SMNSVLGNHHPTPSHGPDGAVPTMADDLGEPAPLWPHDPDAKEKPLHMPGG------DGHRGKSL 530
            .... ..:.|..|:..    :.::.:|:.:         ....:.:..||.      ..|:|.:
  Fly   270 KKKK-SNSKHSRPAQN----LSSITEDMVK---------SPSNQSMARPGSGTELSEQQHKGNT- 319

Human   531 KLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPSHTSTDY 595
            ..:.|||..|||:.:|||.|.|||:..:.|:||::||:|..:.|||||.||:|::|||..:.:::
  Fly   320 HFMRKIPPGAEASNILVGEVDFLERTLSCFIRLSQAVVLGDLTEVPVPTRFVFILLGPPGSQSNF 384

Human   596 HELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLLRSVAAFQRELL 660
            ||:||::||||||::|||.||:|..|..|||.:.||||...|:||.|.:....:...||...:.:
  Fly   385 HEIGRAMATLMSDEIFHEVAYRARKRDHLLSGVDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQEV 449

Human   661 RKR------REREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVFGGLVRDVRRR 719
            |||      .|.::.:.|...|                     |::.|.|||.:||||:.|::|:
  Fly   450 RKRPPELPKEEVDEEEEEARLR---------------------EENGLSRTGRLFGGLINDIKRK 493

Human   720 YPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSELIVSTAVLGVLFSLL 784
            .|.|.||.:|||..||||:.:|:|||.|||.|||||||.|.|...|...|.:||..|.|:.:...
  Fly   494 APWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAAMESLVSGFVCGMGYGFF 558

Human   785 GAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLALVAAEGSFLVRYISPF 849
            ..|||.::|.:||:||||...::||.....:|:|.|.|:|:|:....:.|.|.:.|.||.||:.|
  Fly   559 SGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWVAGICIVLTAIDASALVCYITRF 623

Human   850 TQEIFAFLISLIFIYETFYKLYKVFTEHPL-LPFY-----PPEGALEGSLDAGL-------EPNG 901
            |:|.||.||:.||||:....:..:....|: ...|     ||.|:....:|...       ..||
  Fly   624 TEENFATLIAFIFIYKAIENVMVIGKNFPVNQGIYDCVCTPPIGSNASVIDYAKYNWDSCESYNG 688

Human   902 SAL------PPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIP 960
            :.:      ||||         |..|:|::|..|||.|:..|::|:|:.|.....|:.|.||.:.
  Fly   689 TLVGGDCGTPPTE---------NVFLMSVVLCAGTFLISTVLKEFKNALFFPSIVRQYISDFSVL 744

Human   961 ISILVMVLVDYSITDTYTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLI 1025
            |:|..|...|||: ...||||.||..|..|. ..|.|.|||.....|:  |..:.|..||||..|
  Fly   745 IAIFAMSFFDYSL-GVPTQKLEVPNELKPTL-STRGWLIPPFVEKNPW--WSAIIAVFPALLGTI 805

Human  1026 LIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVM 1090
            ||||:.||||:||::|..:|.||.|:||||.::..|..:|.:.||||..||||.|:.|||:|.:.
  Fly   806 LIFMDQQITAVIVNRKENKLKKGCGYHLDLFILSILIAICSMMGLPWFVAATVLSINHVNSLKLE 870

Human  1091 RTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLS 1155
            ....|||:|||...|||||||.:||...:|:|:::..:|..||:.||||:||||||.||.|:|..
  Fly   871 SECSAPGEKPQFLGVREQRVTHILIFLTIGVSVLLTPLLGNIPMPVLFGVFLYMGVASLKGLQFF 935

Human  1156 QRLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKS-TAASLAFPFLLLLTVPLR 1219
            .|:|::.||||:.|:..::.:|...|:||||.|||.|:.:||::|| :..|:.||.:|::.:.:|
  Fly   936 DRILIMFMPAKYQPDYMFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIR 1000

Human  1220 HCLLPRLFQDRELQALDSEDAEPNFDE----------DGQDEYNELHMP 1258
            .. |..:|..|||:.||  |..|...:          |.:|.::: |.|
  Fly  1001 KA-LDLVFTRRELKILD--DIMPEMTKRAAADDLHKLDAEDNHHQ-HPP 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC4A3	NP_001313488.2	PHA03307	2..>292	CDD:223039	45/266 (17%)
		ae	349..1258	CDD:273290	368/958 (38%)
Ndae1	NP_723263.2	ae	140..1016	CDD:273290	361/926 (39%)
		Band_3_cyto	167..435	CDD:284893	105/282 (37%)
		HCO3_cotransp	476..968	CDD:279322	215/504 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.680