Protein Alignment SLC1A3 and Eaat1

DIOPT Version :10

• Sequence 1: NP_001425387.1
• Gene: SLC1A3 / 6507
• HGNCID: 10941
• Length: 589
• Species: Homo sapiens
• Sequence 2: NP_001369123.1
• Gene: Eaat1 / 34251
• FlyBaseID: FBgn0026439
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 555
• Identity: 224/555 - (40%)
• Similarity: 321/555 - (57%)
• Gaps: 98/555 - (17%)

Human    38 KED---VKSYLFRNAFVLLTVTAVIVGTILGFTLR--PYRMSYREVKYFSFPGELLMRMLQMLVL 97
            |:|   .|:::..|...:.||..|.||.::||.::  ....|.||:.|.|||||:.:|||:.|::
  Fly     5 KQDGGKFKAFMQENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIV 69

Human    98 PLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTK------ENMH 156
            ||::||:.:.:..||...|.|:..||:.||..|||.||::||.:|..:.||:|.|      |::.
  Fly    70 PLLVSSITSAIGGLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESID 134

Human   157 REGKIVRVTAADAFLDLIRNMFPPNLVEACFKQFKTN-YEKRSFKVPIQANETLVGAVINNVSEA 220
            :..|::   ..|..:||:||||..|::::...|.:|. ||..|.. |.|..|          :..
  Fly   135 KASKVL---TPDTLMDLVRNMFTDNIIQSTMFQHRTEIYENTSIS-PAQPME----------NWE 185

Human   221 METLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVI 285
            .::..|            .|.|.||||:||:..|..||.|:|:||.|::||.:|:||:|.:.:.:
  Fly   186 FKSAQR------------EGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWV 238

Human   286 MWSKRKTLCPRAILSEGKARFCKNQGKFIFTKEKKEVHSFCKKRSPQFLYAPVGILFLIAGKIVE 350
            :|                                               .:|:|:.||||.||:|
  Fly   239 IW-----------------------------------------------ISPLGVAFLIAAKIIE 256

Human   351 MEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSAT 415
            ||.:......|..|.:||::||.:|....:.:::||.||:.|:.:|..|.|.|.||.||.|||||
  Fly   257 MESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSAT 321

Human   416 LPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITA 480
            :|:|.||| :|.|:|.||||||:||||||||||||||||:||:||||......:||.|:.:||||
  Fly   322 MPLTIKCL-DNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITA 385

Human   481 TAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLS 545
            |||||||||||||||||||:||.:|||...|::|||||||.|||.|||.||:.|:||..:|.|||
  Fly   386 TAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDALGTILVNHLS 450

Human   546 RHELKNRD---------VEMGNSVIEENEMKKPYQ 571
            :::|.:.|         :|:|.:   .:|||: .|
  Fly   451 KNDLASVDRLNAEPHELLELGPN---GHEMKEXRQ 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC1A3	NP_001425387.1	None
Eaat1	NP_001369123.1	GltP	20..448	CDD:440912	209/501 (42%)