Protein Alignment SLC1A3 and glt-4

DIOPT Version :10

• Sequence 1: NP_001425387.1
• Gene: SLC1A3 / 6507
• HGNCID: 10941
• Length: 589
• Species: Homo sapiens
• Sequence 2: NP_509075.3
• Gene: glt-4 / 188744
• WormBaseID: WBGene00001622
• Length: 499
• Species: Caenorhabditis elegans
• Alignment Length: 546
• Identity: 231/546 - (42%)
• Similarity: 328/546 - (60%)
• Gaps: 77/546 - (14%)

Human    48 NAFVLLTVTAVIVGTILGFTLR-PYR-MSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAA 110
            |..:|.||..|:||..|||:|| |.: .|.|.:.|..|||:|.::||:||:||:|:||::|.:|:
 Worm     8 NLLLLFTVLGVVVGIGLGFSLRDPSKAWSKRHLSYLRFPGDLFVQMLKMLILPMIMSSIITSLAS 72

Human   111 LDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENM-----HREGKIVRVTAADAF 170
            |||..:|::||.:::||..||..||.:||::|.:|.|||.|..|:     |.:......||.|..
 Worm    73 LDSGTAGRLGMVSMIYYTLTTFFAVFLGIVLVSVIKPGKWTTTNIEDLVGHVKTTPCVATAVDTI 137

Human   171 LDLIRNMFPPNLVEACFKQFK--TNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVP 233
            :||:::.||.||:||.|:..|  ..:...:.::|.:...|:       ..|.....|.:.|::|.
 Worm   138 IDLMKSCFPENLIEATFRSQKICLKFFNGTTEIPPEIAMTM-------SPEQRAQFTEVPEKIVS 195

Human   234 VPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWSKRKTLCPRAI 298
                 :|:|.|||||||:..|.|||.:.|.|:.::.||.||....|:|:..::
 Worm   196 -----DGMNILGLVVFSVALGIVIGVIGEDGKPMKNFFKSLEACSMKLIGWVI------------ 243

Human   299 LSEGKARFCKNQGKFIFTKEKKEVHSFCKKRSPQFLYAPVGILFLIAGKIVEMEDMGVIGGQLAM 363
                                               :|:||||.||||.:||.|:|.|....:|..
 Worm   244 -----------------------------------IYSPVGITFLIAAQIVGMKDPGQELHRLMG 273

Human   364 YTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNG 428
            |.:|||:||||||.:|:|||..::.|:||..|:||:.|||:|||.|||||||||::.||.||||.
 Worm   274 YVITVILGLLIHAFVVIPLLCVVLARRNPIKFVGGMAQALLTALATSSSSATLPLSIKCCEENNK 338

Human   429 VDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQA 493
            ||.||||||||:||||||||||||||:|||:|:|....:|:.|:::.:|:|||.|||||||||||
 Worm   339 VDPRVTRFVLPLGATINMDGTALYEAVAAIYISQCYGNDLSLGEVVLVSLTATLASIGAAGIPQA 403

Human   494 GLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSR-------HELKN 551
            |:|||::||.::||||:...||..||:.|||||||.||.|||:...::|.|..       |.|..
 Worm   404 GIVTMIMVLIAIGLPTNLFILIFPVDFMLDRLRTTVNVHGDSIATAVIERLCEDQLQKGGHHLDT 468

Human   552 RDVEMGNSVIEENEMKKPYQLIAQDN 577
            .|  .|.|::..|....|.::...:|
 Worm   469 ND--QGYSMLSTNASPDPKRITIGNN 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC1A3	NP_001425387.1	None
glt-4	NP_509075.3	GltP	10..453	CDD:440912	220/501 (44%)