DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDK15 and cdk15

DIOPT Version :9

Sequence 1:	NP_001353315.1	Gene:	CDK15 / 65061	HGNCID:	14434	Length:	435	Species:	Homo sapiens
Sequence 2:	XP_005165792.1	Gene:	cdk15 / 791619	ZFINID:	ZDB-GENE-060421-7193	Length:	461	Species:	Danio rerio

Alignment Length:	447	Identity:	265/447 - (59%)
Similarity:	321/447 - (71%)	Gaps:	32/447 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    16 CYHCSEGGEAHSCRRSQPETTEAAF--KLTDLKEA---------SCSMTSF-------------- 55
            |:.|  |.:.:...|   |..|..|  ::.:||:.         :.||:|.
Zfish    20 CWCC--GDKTNEVGR---EVKEEMFEMRVEELKDVAKMEEKPSKTWSMSSLPDAELGELDGVEKP 79

Human    56 HPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKG 120
            .|......:.::.:.:|.|||||....:..:|.|||:..|.||.|:|||||||||||:|||||||
Zfish    80 QPHWFHTLQVRRLRVQRGRSNSDPMGGKSFQQEFQWKTGLQFGNATSYLNLEKLGEGTYATVYKG 144

Human   121 ISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDL 185
            ||||||.|||||||.|..|||:||||||||||||||||||||||||||||:|:|||||||:.|||
Zfish   145 ISRINGHLVALKVIHMKTEEGIPFTAIREASLLKGLKHANIVLLHDIIHTRESLTFVFEYVQTDL 209

Human   186 AQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKS 250
            ||||.|||||||.:|:|||||||||||:|||.:.:|||||||||||||:|||||||||||||:||
Zfish   210 AQYMIQHPGGLHSYNIRLFMFQLLRGLSYIHGRRILHRDLKPQNLLISYLGELKLADFGLARSKS 274

Human   251 IPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWE 315
            ||.||||:|||||||||||.|:|:|:||:.|||||||||||||.||.|.||||:::.|||.|||.
Zfish   275 IPCQTYSAEVVTLWYRPPDVLMGSTDYSTALDIWGAGCIFIEMLQGSPAFPGVADVFEQLLKIWT 339

Human   316 VLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVP-EAEDLASQMLKGFPRDRVSAQ 379
            |:|||||:.|||||.||||.||||....|:....||.||.::| :.||||.|||...|:||:|||
Zfish   340 VIGVPTEEIWPGVSDLPNYKPEWFLPCKPQQFRDVWKRLSQLPYKTEDLAQQMLMMNPKDRISAQ 404

Human   380 EALVHDYFSALPSQLYQLPDEESLFTVSGVRLKPEMCDLLASYQKGHHP-AQFSKCW 435
            :||:|.||:.||..|..|.|..|:|.|.||||:.|..|:.:..::...| |..:|||
Zfish   405 DALLHPYFNTLPPPLMHLRDTVSIFKVPGVRLESEARDIFSPSRRTKTPLAPLAKCW 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDK15	NP_001353315.1	STKc_PFTAIRE2	102..387	CDD:270852	217/285 (76%)
cdk15	XP_005165792.1	STKc_PFTAIRE2	126..412	CDD:270852	217/285 (76%)
cdk15	XP_005165792.1	PLN00009	127..415	CDD:177649	218/287 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194324189
Domainoid	1	1.000	451	1.000	Domainoid score	I3557
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H64641
Inparanoid	1	1.050	517	1.000	Inparanoid score	I6288
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51470
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	1	1.000	-	-		FOG0003670
OrthoInspector	1	1.000	-	-		oto42827
orthoMCL	1	0.900	-	-		OOG6_107080
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3201
SonicParanoid	1	1.000	-	-		X2541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300