Protein Alignment CDK15 and mde3

DIOPT Version :10

• Sequence 1: NP_001353315.1
• Gene: CDK15 / 65061
• HGNCID: 14434
• Length: 435
• Species: Homo sapiens
• Sequence 2: NP_595581.1
• Gene: mde3 / 2541254
• PomBaseID: SPBC8D2.19
• Length: 559
• Species: Schizosaccharomyces pombe
• Alignment Length: 356
• Identity: 102/356 - (28%)
• Similarity: 165/356 - (46%)
• Gaps: 78/356 - (21%)

Human    75 SNSDCFQEEDLRQG-FQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISR-ING--QLVALKVIS 135
            ||...:...||.|. |:.|          ||..:|||:||:.|||....: .||  :.||:|.:.
pombe     2 SNESIYSVLDLTQVIFEDR----------YLVKQKLGDGSFGTVYLAQRKEKNGLYETVAVKKLK 56

Human   136 MNAEEGVP---FTAIREASLLKGL-KHANIV-LLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGG 195
             |:.:..|   ...:||:..|:.: ||..:: ||...:.....:..|.|:|..:|.|...:..|
pombe    57 -NSSKPKPKHELLKLRESLALRKISKHPCLIDLLETFMDPYRNIFLVMEFMDCNLFQLFKRRQG- 119

Human   196 LHPHNVRLF--------MFQLLRGLAYIHHQHVLHRDLKPQNLLISHLG--------ELKLADFG 244
                  |||        :.|::.|:.:||....:|||:||:|:|:..:.        .:||.|||
pombe   120 ------RLFTKETAFNILLQIISGIEHIHKHGFMHRDIKPENILVKRISPKPISSRYSIKLGDFG 178

Human   245 LARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQ 309
            ||| .|:.|...:..|.|.|||.|:.||.:..|:..:|::..|||..|::..:||||| .|..:|
pombe   179 LAR-PSVSSDPLTEYVSTRWYRAPELLLRSGSYNHSVDLYAFGCIVFEIYSLKPLFPG-RNETDQ 241

Human   310 LEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQM------L 368
            |.::.|:||.      ||:.:|.             :|| .|:      :|::||.::      .
pombe   242 LNRVCEILGN------PGIDELD-------------TLH-YWS------QAKELAKRLGFMLPPT 280

Human   369 KGFPRDRVSAQEALVHDYFSALPSQLYQLPD 399
            |.:|..::..|.. ...:...:|..|...||
pombe   281 KPYPIQKLLPQNC-PEGHAKMIPCLLAWNPD 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK15	NP_001353315.1	STKc_PFTAIRE2	102..387	CDD:270852	91/314 (29%)
mde3	NP_595581.1	STKc_MAK_like	21..323	CDD:270824	95/327 (29%)