Protein Alignment SLC1A2 and Eaat1

DIOPT Version :10

• Sequence 1: XP_047283392.1
• Gene: SLC1A2 / 6506
• HGNCID: 10940
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_001369123.1
• Gene: Eaat1 / 34251
• FlyBaseID: FBgn0026439
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 213/534 - (39%)
• Similarity: 320/534 - (59%)
• Gaps: 50/534 - (9%)

Human    71 KNLLLTLTVFGVILGAVCGGLLRLAS-PIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLS 134
            :|:|...||.||.:|.:.|.:::.:: ......:|.|:|||:|.:||||.||:||::||:.:.:.
  Fly    17 ENVLTMATVIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVSSITSAIG 81

Human   135 GLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPK--LKKQLGPGKKNDEVSSLDAFL 197
            |||...|.::.|||:.||..|||.|.:||:.||..:.||...  ::.|.....|..:|.:.|..:
  Fly    82 GLDLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASKVLTPDTLM 146

Human   198 DLIRNLFPENLVQA-CFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKG 261
            ||:||:|.:|::|: .||....:.:...::|....|                            .
  Fly   147 DLVRNMFTDNIIQSTMFQHRTEIYENTSISPAQPME----------------------------N 183

Human   262 LEFK----DGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIAC 322
            .|||    :|.|||||:.|.:..|..:|:|.::.:|:.|||..|:|.:|.:...::|.||||:|.
  Fly   184 WEFKSAQREGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAF 248

Human   323 LICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITAL 387
            ||..|||.::.:....:.||.|.:||:|||.:||...:.:|:|:.||:.|:.:.|.:.|...||.
  Fly   249 LIAAKIIEMESIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAF 313

Human   388 GTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQ 452
            ||.||:.|:|:|.:|| :|:|||.||||||:|||||||||||||||||||:||||...:....|.
  Fly   314 GTGSSSATMPLTIKCL-DNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGT 377

Human   453 IVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFG 517
            ||.||:|||.||:|||.||.||||||:::|..|||..:|:||::||||||||.||::||:.|:.|
  Fly   378 IVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLLDRFRTTINVMCDALG 442

Human   518 AGIVYHLSKSELDTIDSQH-RVHEDIEMTKTQSIYDDMKNHRESNSNQCVYAAHNSVIVD----- 576
            ..:|.||||::|.::|..: ..||.:|:....   .:||. |:|:    :.|.:... ||
  Fly   443 TILVNHLSKNDLASVDRLNAEPHELLELGPNG---HEMKEXRQSS----LGAYNRKRXVDMSRLW 500

Human   577 ECKVTLAANGKSAD 590
            .|...|.:|...:|
  Fly   501 ACFHILPSNDSDSD 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC1A2	XP_047283392.1	SDF	74..524	CDD:425646	192/457 (42%)
Eaat1	NP_001369123.1	GltP	20..448	CDD:440912	192/456 (42%)