Protein Alignment SLC1A2 and Eaat2

DIOPT Version :10

• Sequence 1: XP_047283392.1
• Gene: SLC1A2 / 6506
• HGNCID: 10940
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_001162844.1
• Gene: Eaat2 / 33247
• FlyBaseID: FBgn0026438
• Length: 579
• Species: Drosophila melanogaster
• Alignment Length: 543
• Identity: 232/543 - (42%)
• Similarity: 351/543 - (64%)
• Gaps: 31/543 - (5%)

Human    69 LGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGL 133
            |.:||:|.:|:.||:||.:.|..||..: :|.|.:|||::||::.||:||::||||:|||||.|.
  Fly    46 LSENLMLLVTLSGVLLGVILGLSLRPLN-LHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGS 109

Human   134 SGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLD 198
            :.|:||.:|::..|.:||:.||:...|.||:.|||.||||||.|............|:.||:.||
  Fly   110 ASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPGNPDLHNADDRSTDRRAVNLLDSLLD 174

Human   199 LIRNLFPENLVQACFQQIQTVTKKVLVAPPP------DEEAN---ATSAVVSLLNETVTEVPEET 254
            |.||:||:||.||..||..||     ..|.|      :|..|   |:.:....|:|.:||
  Fly   175 LGRNVFPDNLFQASIQQAHTV-----YLPKPSILHVFNETMNDTLASGSEAQRLSEDLTE----- 229

Human   255 KMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLG 319
            .:|:.:.::::.|.|.||::.|.:.||..:|.:|.:.:::||||..:.|::||:|..:||.:|:|
  Fly   230 DVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVG 294

Human   320 IACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWI 384
            |:.:|.|||:::.||.:|..||..::|||.||:.|:..:.:..|||||.|:|||.|:||:.||.:
  Fly   295 ISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAML 359

Human   385 TALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLD 449
            ||..|||:|..||:||||:.|.|.:|.|:||||||:|..|||||||||.|||:||||||:|:||.
  Fly   360 TAFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLG 424

Human   450 GGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGD 514
            .|:::||.||:|.||:.:||:|||.||.:|::|||:..|.:|::||.||||.:||:||:.|::||
  Fly   425 FGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGD 489

Human   515 SFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRE----------SNSNQCVYAA 569
            .:.|.:|..||:.||..:|:....::|:. ..|.:.:.....|.:          ..|::||...
  Fly   490 CYTAAVVEELSRKELMALDAASVNYQDMP-AGTPNGHGHGHGHHDGGLLEGQTELETSSKCVMTM 553

Human   570 HNSVIVDECKVTLAANGKSADCS 592
            .:||:||...|....|.:...|:
  Fly   554 TDSVVVDISAVMNNVNLQQEHCN 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC1A2	XP_047283392.1	SDF	74..524	CDD:425646	211/458 (46%)
Eaat2	NP_001162844.1	SDF	51..499	CDD:425646	211/458 (46%)