DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC1A1 and Eaat2

DIOPT Version :9

Sequence 1:	XP_011516309.1	Gene:	SLC1A1 / 6505	HGNCID:	10939	Length:	547	Species:	Homo sapiens
Sequence 2:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	210/504 - (41%)
Similarity:	314/504 - (62%)	Gaps:	48/504 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    11 WKRFLKNNWVLLSTVAAVVLDCKPHGDPDHMSSTELSKVVVCTGITTGVLVREHSNLSTLEKFYF 75
            ::|:|..|.:||.|::.|:|                       |:..|:.:|. .||........
  Fly    42 YRRWLSENLMLLVTLSGVLL-----------------------GVILGLSLRP-LNLHGDSIMLI 82

Human    76 AFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIK 140
            ::|||:.||:|||:||||:|||:|.|.|:|::.::|||.||.:||:..|:.....|||.||:.|.
  Fly    83 SYPGELFMRVLKLMILPLVISSLIAGSASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIH 147

Human   141 PGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEE 205
            ||.........|:.....|:.:|::|||.||:||:||.||..||..|    |..|....:::..|
  Fly   148 PGNPDLHNADDRSTDRRAVNLLDSLLDLGRNVFPDNLFQASIQQAHT----VYLPKPSILHVFNE 208

Human   206 SFTAVMTTA-----ISKNKTKEYKIVG--MYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFF 263
            :....:.:.     :|::.|::..:|.  .|..|.|.||::.||||||..:|.:|:|||::||||
  Fly   209 TMNDTLASGSEAQRLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFF 273

Human   264 NALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMA-------TVLTGLAIHSI 321
            .|:.:..||:|..:|...|:||..:|||||:.|.|      |||.|:       ||..|:.|:..
  Fly   274 AAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGD------LGLVMSQLMWFIVTVAIGVFIYQF 332

Human   322 VILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGA 386
            |::..|||:|||:|||:|..|:.||:|||...:|::|.||:||||..|..:||.||||||||:|.
  Fly   333 VVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGC 397

Human   387 TINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGL 451
            .|||||||||.|||::||||::.:.||.|:::|:.:|:|:||:.:|.||.|.||.:::||:|:..
  Fly   398 NINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDA 462

Human   452 PAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSS 500
            |.:||||:.||||.:||.||..|:|||.:...:||:||:|||..:|.:|
  Fly   463 PVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVVEELSRKELMALDAAS 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC1A1	XP_011516309.1	SDF	74..488	CDD:278787	190/427 (44%)
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	198/478 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm40767
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.730