DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Megf6 and NimB2

DIOPT Version :9

Sequence 1:	NP_075244.1	Gene:	Megf6 / 65049	RGDID:	621188	Length:	1574	Species:	Rattus norvegicus
Sequence 2:	NP_723857.1	Gene:	NimB2 / 260645	FlyBaseID:	FBgn0028543	Length:	421	Species:	Drosophila melanogaster

Alignment Length:	392	Identity:	102/392 - (26%)
Similarity:	128/392 - (32%)	Gaps:	146/392 - (37%)

- Green bases have known domain annotations that are detailed below.

  Rat  1094 SCLHGGIC--------------DRLTGHCLCPAGWTGD--KCQSSCVSGTFGVH----CEEHCA- 1137
            |.:..|:|              |:..|:     |.|.|  :.|..|.......|    ||..||
  Fly   128 SAMASGVCYKEVPTASLLRNSRDQFVGN-----GTTPDMSRIQVCCDGYERNPHIYRRCEPICAD 187

  Rat  1138 -CRKGASCHHVTGACFCPPGWRGPH-------CEQACPRGWFGEACAQRCLCPTNASCHHVTGEC 1194
             ||.|...  ....|.|.||    |       |...||.|.....|.:|             .||
  Fly   188 DCRNGICT--APNTCVCIPG----HVRTAEGKCISTCPLGCGNGVCDER-------------NEC 233

  Rat  1195 RCPPGF-----TGLSCEQACQPG-TFGKDCEHLCQCPGETWACDPASGVCTCAAGYHGTGCLQRC 1253
            :|..|:     |...|:..|:|| :||:     |..|.:          |.|..||      :..
  Fly   234 KCREGYSLEPETRKYCQPECKPGCSFGR-----CVAPNK----------CACLDGY------RLA 277

  Rat  1254 PSGRYGPGCEHICKCLNGGTCDPATGACYCPAGFLGAD------CSLACPQGR-FGPSCAHVCAC 1311
            ..|    .||.:|.....|.| .|.|.|.|.||:|...      ||:.|..|| .||.   :|.|
  Fly   278 ADG----SCEPVCDSCENGKC-TAPGHCNCNAGYLKLQGRCEPICSIPCKNGRCIGPD---ICEC 334

  Rat  1312 RQGAACDPVSGACICSPGKTGVRCEHGCPQDRFGKGCELKCACRNGGLCHATNGSCSCPLGWMGP 1376
            ..|...|..|..|:              |:      |:|.|.   .|:| ..|..|.|..|::..
  Fly   335 ASGFEWDRKSAECL--------------PK------CDLPCL---NGVC-VGNNQCDCKTGYVRD 375

  Rat  1377 H-----CEHACPAGRYGAACLLECFCQNNGSCEPTTGACLCGPGFYGQACEHSCPSGFHG-PGCQ 1435
            .     |:..||.|           || ||.|. ....|:|.|||        ..||..| ..||
  Fly   376 EHQRNICQPHCPQG-----------CQ-NGYCS-APNFCICRPGF--------IKSGIKGRQTCQ 419

  Rat  1436 RV 1437
            .|
  Fly   420 AV 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Megf6	NP_075244.1	EMI	42..112	CDD:284877
		FXa_inhibition	127..162	CDD:291342
		vWFA	<154..202	CDD:294047
		vWFA	<237..285	CDD:294047
		vWFA	<284..325	CDD:294047
		FXa_inhibition	338..373	CDD:291342
		vWFA	<371..410	CDD:294047
		vWFA	<413..452	CDD:294047
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1555..1574
NimB2	NP_723857.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900