DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chd8 and kis

DIOPT Version :9

Sequence 1:	XP_006251970.1	Gene:	Chd8 / 65027	RGDID:	620696	Length:	2589	Species:	Rattus norvegicus
Sequence 2:	NP_001137761.1	Gene:	kis / 33185	FlyBaseID:	FBgn0266557	Length:	5517	Species:	Drosophila melanogaster

Alignment Length:	3534	Identity:	1040/3534 - (29%)
Similarity:	1442/3534 - (40%)	Gaps:	1265/3534 - (35%)

- Green bases have known domain annotations that are detailed below.

  Rat    19 SLTDDSFNQVT-QDPIEEALGLPSSLDSLDQMNQ-----DGGSGDVGNSSASDLVPPPEETASTE 77
            :||.....|:. |.||.:....|.....|...||     |..:..:|::.       |..:..|.
  Fly   722 TLTSPHHQQMQHQSPIHQQQQSPHHQQHLPSYNQSQQQFDPFANILGDNQ-------PAASQQTM 779

  Rat    78 LPKESTAPAPESLTLHDYTTQ-------PTSQEQP-AQPVLQT-----STPTSGLLQV------- 122
            .|...::|.|..:....:.||       |.||:|. :||..||     |||:..|..:
  Fly   780 SPAHVSSPVPAQMQQQQHQTQQQPSQQVPQSQQQQVSQPQQQTQQQQPSTPSHHLSSILNETANS 844

  Rat   123 ------------SKSQEILSQGNPFMGVSATAVSPSNT----------------------GG--Q 151
                        |.:....|..|..:....|:|..||:                      ||  :
  Fly   845 NDSSTLAVAANDSNNSSSNSSTNSIVNNQPTSVHDSNSQSSINSSSNNQQQLLMDNTNSHGGNSE 909

  Rat   152 PSQSAPKIVILKAPPNSSVTGAHVAQIQAQGITSTAQPLVAGTANGGKVTFTKVLTGTPLRPGVS 216
            .:|:|...|.|....:.|...|.||.: |....|.|..|:...:......|.|   ......|:.
  Fly   910 SAQNAGVDVGLFDNNSMSSNSAAVAAV-ASNAASAAAALLDSNSQSSNAEFEK---NQSEGEGLG 970

  Rat   217 IVSG------------NTV-------LATKVPGNQAAVQRIVQPSRPVKQ-------------LV 249
            :|.|            |:|       |:|::|..|..:|.  :|:..::|             |:
  Fly   971 VVEGVIANETDLPQDENSVSKTQDITLSTELPTIQDDLQE--KPTAEMEQTQLGQSLGDLSKSLL 1033

  Rat   250 LQP--VKGSAPAGNPGATG--PPLKPAVTLTSTPAQGESKRITLVLQQPQSGGP----------- 299
            .:|  |:.|....:..|.|  ||..|.:.:|..|.|          |.|..|.|
  Fly  1034 EEPKTVEESGEDKSQSAPGVAPPADPIIPVTQPPQQ----------QMPPIGMPMHPIAPGYEAQ 1088

  Rat   300 ---QGHRHVVL---GSLPGKI----VLQGNQLAALTQAKSAQGQ------PAKVVTIQLQVQQPQ 348
               |||...::   |..||..    :|...::|||.|    |.|      |...:..|.::.:.|
  Fly  1089 AQGQGHMPPMMPPYGGAPGMYPPYPMLHQQEIAALQQ----QIQELYCMPPGHELQHQDKLMRMQ 1149

  Rat   349 QKIQIVPQ----------PPSSQPQPQPP---PSAQPLTLSSVQQAQIMGP------GQNPGQRL 394
            :::.::.|          |.....|..||   |...||    :.|..:..|      |:..|:..
  Fly  1150 ERLNLLTQHEVNDQCAGGPQCLLFQNVPPMYGPPGNPL----LNQQMVESPQVSSTTGRGRGKSA 1210

  Rat   395 SVPLKMVLQPQAGSSQGASSG-------------LSVVKVLSASEVAALSSPASCAPHTAGKT-- 444
            :.|.|    |:|...:.|..|             :.....:|:.....|.....|....||.|
  Fly  1211 NKPRK----PRAKKGEKAQVGQQQDLMDISGNVAMGAANAVSSIPTTQLPVSEDCVTQGAGDTSV 1271

  Rat   445 --------GMEENRRLEH--------------QKKQEK------ANRIVAEAIARARARGEQNIP 481
                    ||.:..:..|              :||..|      .|:...:...:|:...:.|.|
  Fly  1272 VGMLEYSEGMGDLSQDVHSANELDTSTDGSGKKKKPRKPRTPKDPNKPPRDRTPKAKKPKDPNDP 1336

  Rat   482 RVLNEDELPSVRPEEEGEKKRRKK---------SSGERLKEEKPKKSKTAAA------------- 524
               |..|.|:...:..|..||||:         ..|..:::.||...|..:|
  Fly  1337 ---NSTETPAAVKKRAGASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKAGSADGEAETTSGGTGV 1398

  Rat   525 ----------------------------------------------------SKTKGKSKLNTIT 537
                                                                .::..:|:.|..:
  Fly  1399 DGESPDYDDIPVSKIPRGSNEDEKEAEAGDETVDSVPDSAGDPASTPSRRDRKRSTARSRRNANS 1463

  Rat   538 PVVGKKRKRNTS------------------SDNSD--VEVMPAQSPREDEESSIQKRRSNRQVKR 582
            ...|..||...|                  ||..|  ::..|..||..|.|....||||:|..:|
  Fly  1464 EEGGSARKNRGSLSAKALKKRRNRGRIVPESDGEDDTLDRTPPPSPPPDSEMDSNKRRSSRNTQR 1528

  Rat   583 KKYTEDLDIKITDDEEEEEVDVTGPIKP-----------------EPILPEPVPEPD-----GE- 624
            |||.:|:.::.:||  |..:.|..|:|.                 |...|:...|.|     ||
  Fly  1529 KKYIDDVMLRFSDD--ENSLLVASPVKKDKKPSANASNSNAGSDVEKTEPQSGAEGDAAQEVGEE 1591

  Rat   625 --TLP---SMQ-------------------------------FFVENPSEEDAAIVDKVLSMRVV 653
              .||   |.|                               :...|..:||:.:|..||:||:.
  Fly  1592 KSNLPLDESSQLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQLVLAMRMG 1656

  Rat   654 KKEL----------------------------PSG------------------------------ 660
            |:||                            |.|
  Fly  1657 KRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGDEKFKTEGESKKDLTDSEETKLESSAMEVD 1721

  Rat   661 ----------------------------------------------------------------- 660

  Fly  1722 SKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKTEENSKAIEEDKSSTVLTA 1786

  Rat   661 ----------------------------------------------------------------- 660

  Fly  1787 DHAKEPETVLEKMEVDEKANDDQSAVSKAEGSDEKSTDDSNPEEATTEKNKESLEIEGEKERVKE 1851

  Rat   661 ----------QYTEA-------------EEFFVKYKNYSYLHCEWATISQLEK-DKRIHQKLKRF 701
                      :.|||             ||:||||:|:|||||||.|..:|.| |:|:..|::||
  Fly  1852 GEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRF 1916

  Rat   702 KTKMAQMRHFFHE-DEEPFNPDYVEVDRILDESHSVDKDNGEPVIYYLVKWCSLPYEDSTWELKE 765
            :.|.:|..:.|.. ::||||.|:.||||:||.|...|:.:||...:|||||.||||||.||||:|
  Fly  1917 QQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEE 1981

  Rat   766 DVDEGKIREFKRIQS--RHPELKRVNRPQANAWKKLELSHEYKNRNQLREYQLEGVNWLLFNWYN 828
            |||..||.::.|...  :..|.|...||....|||||.:..||..|.||.|||||:|||.|:|||
  Fly  1982 DVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYN 2046

  Rat   829 RQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWTEMNTIVYHGSL 893
            ..||||||||||||||||:.|:..||..||.||||||||||||.||:|||..||:||.:|||||:
  Fly  2047 THNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPLSTIPNWQREFEGWTDMNVVVYHGSV 2111

  Rat   894 ASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNC 958
            .|:||||.||.|.|...|:::....||:.||||||||::|..:|:...||..:||||||||||||
  Fly  2112 TSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNC 2176

  Rat   959 KLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKTEEQVQKLQA 1023
            |||:.|:.::|||:|||:||||||.:.||||||:|||||||.|:.||:.:||.|:|||:|.||||
  Fly  2177 KLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQA 2241

  Rat  1024 ILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLSKGAGHTNMPNLLNTM 1088
            :||||||||||:||||:||||:|||||||||||||||||.|||:|||||.||....|:|||:|||
  Fly  2242 LLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTM 2306

  Rat  1089 MELRKCCNHPYLINGAEEKILMEFREACHIIPQDFHLQAMVRSAGKLVLIDKLLPKLKAGGHKVL 1153
            |||||||.||||:|||||:|..:|:......|:.:: :.::.||||:||||||||||||.||:||
  Fly  2307 MELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYY-KNLILSAGKMVLIDKLLPKLKANGHRVL 2370

  Rat  1154 IFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINL 1218
            ||||||||||||||||:.|:|.:||||||:||||||.||||:|||.||||||||||:||||||||
  Fly  2371 IFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINL 2435

  Rat  1219 TAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQ 1283
            |||||.||:|||||||||||||||||||||.|.||:|||:.||:||||||||||:||||||||||
  Fly  2436 TAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQ 2500

  Rat  1284 SMS---GRDGNITGIQQFSKKEIEDLLRKGAYAAIMEEDDEGSKFCEEDIDQILLRRTTTITIES 1345
            ||:   .:|||   .:|.|||||||||:||||.|:|::|:.|.||||||||.||.|||..||:||
  Fly  2501 SMNTQGSKDGN---NKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMES 2562

  Rat  1346 EGKGSTFAKASFVASENRTDISLDDPNFWQKWAKKADLDMDLL--NSKNNLVIDTPRVRKQTRHF 1408
            | |||||:||||.||.||:||::|||:||.|||||.|:|.|..  :...:||:..||.|.|.:.:
  Fly  2563 E-KGSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRY 2626

  Rat  1409 STLKDDDLVEF----SDLESEDDE-------RPRSRRHDR------------------------- 1437
            .   .:|::|.    |..|:.|:|       |.|..:.||
  Fly  2627 G---HEDVMELNSEESSNENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEE 2688

  Rat  1438 --HHTYGRTDCFRVEKHLLVYGWGRWRDILSHGRFKRRMTERDVETICRAILVYCLLHYRGDENI 1500
              :..:.:::||:|||.||.:|||||.::|..|:|||...:.|||...|.||:|||..|:|||.|
  Fly  2689 IQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKI 2753

  Rat  1501 KSFIWDLISPAENGKTKEL-QNHSVFHVSPFPGLSIPVPRGRKGKKVKSQS-------------- 1550
            |:||||||:|.|:|:.::: ::||        ||...|||||.|.|...:|
  Fly  2754 KTFIWDLITPTEDGEVQKISRDHS--------GLHNLVPRGRNGGKSNKESTGVSTPAPGSASGS 2810

  Rat  1551 ----TFDIHKAD-----------------------------WIR--KYNPDTLFQDESYKKHLKH 1580
                |...||:.                             |.:  ||:.|. :.:.:|||||..
  Fly  2811 NSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADA-YLEGAYKKHLGR 2874

  Rat  1581 QCNKVLLRVRMLYYLRQEVIGDQAEKVLGGAIASEIDIWFPVVDQLEVPTTWWDSE-ADKSLLIG 1644
            ..||||||||||||::.|||||..:::......||:.|..|.... :||::||:.. .|||||:|
  Fly  2875 HANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPD-QVPSSWWNPICCDKSLLVG 2938

  Rat  1645 VFKHGYEKYNTMRADPALCFLEKAG---RPDDKAIA----------AEHRVLDNFSDLVEGIDFD 1696
            .:|||.|.|..|||||.|||:...|   ..||.|:.          ::|...|...|  :|....
  Fly  2939 TYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDD--DGTTTT 3001

  Rat  1697 KDCE--------------DPE---------------------------------YK----PLQG- 1709
            ||.:              |||                                 ||    |.:|
  Fly  3002 KDSDSTKLTGGDNKDSLLDPERPSSSGKSSSENASGGNDKTESENDATTVSESSYKSEVLPGKGS 3066

  Rat  1710 ----------------------PPK--------------DPDDEGDP------------------ 1720
                                  .||              ||.|...|
  Fly  3067 DLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASVSCDPADSSSPEAAGKAQGTGVQTGDAGE 3131

  Rat  1721 LMMMDEE-------------------------ISVIDGDE------------------------A 1736
            |.:..|:                         |:..:||:                        .
  Fly  3132 LDIESEKKDNEKETKESTGDAPAVEAKKDSAAIARAEGDKTESCTNNATTNISTTTTTTTITNTT 3196

  Rat  1737 PVTQQP-----------------GHL------------------------FWPPGSALTARLRRL 1760
            ..|..|                 .||                        .||....|..||||:
  Fly  3197 TTTNNPSSKAANSNNTTDHANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRV 3261

  Rat  1761 VTAYQRSYKREQMKIE------------------------------------------AAERGDR 1783
            :|||||:||:|::|::                                          ::.:.|.
  Fly  3262 ITAYQRNYKKEELKLQQKAKLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSGGSGIGSSAQHDA 3326

  Rat  1784 RRRRCEAAFKLK----------------------------------------------------- 1795
            ..|..:|..:.:
  Fly  3327 SGRSLQALMQSQGASTSAAAAAAASSAGGSCSGSGQVGMGGAGVMPAMPTAADISLMLSILNTTD 3391

  Rat  1796 -----------------------------EIARREKQ--------QRWTRREQTDFYRVVSTFGV 1823
                                         |:|.:|::        ::|.|||:.:|.||::.:||
  Fly  3392 VNQLANLDINKLAMYLVSMNNKMERQGKMELAAKERESQRLQLIPKKWNRREEYEFLRVLTGYGV 3456

  Rat  1824 E--------------YDPDNMQFHWDRFRTFARLDKKTDESLTKYFHGFVAMCRQVCRLPPAAGD 1874
            :              ..||     |.:|:..|.|::|:||:||.|:..|||||::...|..:..:
  Fly  3457 DLHVSTPMASSNGSSLSPD-----WTKFKQMAHLERKSDETLTDYYKVFVAMCKRQAGLKLSESE 3516

  Rat  1875 EPPDPNLFIEPITEERASRTLYRIELLRRLREQVLCHPLLEDRLALCQPPGLELPKWWEPVRHDG 1939
            ...:.  .||.|.:|.|...|.|:|:|.:||| |..:|:||:||.|| ....:.|.||||.|||.
  Fly  3517 RGLEG--IIEEIEKEHAKLILDRLEVLAKLRE-VARNPMLEERLKLC-TKNADTPDWWEPGRHDK 3577

  Rat  1940 ELLRGAARHGVSQTDCNIMQDPDFSFLAARMNYMQNHQA------------GASAASLSRCSTPL 1992
            ||:....:||:.:::..|..||:|||..:...:::..:|            ...|..|:...
  Fly  3578 ELITAVLKHGLYRSETFIFNDPNFSFGESEKRFIRELEAQIQRTIKLEAFNAEKAEKLAAAE--- 3639

  Rat  1993 LHQQCTSRTASPSPLRPDVPAEKSPEENAVQVPS----LDSLTLKLEDEVVARSRLTPQDYEIRV 2053
             ....|.:.|:         .||:..|.|..|.:    ||...:..|..:...|.:||...||:
  Fly  3640 -KDAATEKAAA---------TEKAAAEKAASVKNEVIDLDDELMTNESVIKKESPVTPIKEEIK- 3693

  Rat  2054 ASSDTAPLSRSVPPVKLEDDDDSDSELDLSKLSPSSSSSSSSSSSSSSSDESEDEKEEKLTADRS 2118
              |:.:|          |..|.:|:..|       .:|.:..|:.....::...|..||...|.|
  Fly  3694 --SEESP----------EKHDTADNLED-------KNSDAEESTKIKGKEDFNPETTEKEALDES 3739

  Rat  2119 RPKLYDEESLLSLTMS-QDGFPNEDGEQMTPELLLLQERQRASEWPKDRVLINRIDLVCQAVLSG 2182
            .....|:.|..:|... :|..|:||  :|..|.|.:.|.......|:.          |......
  Fly  3740 TNLNKDKSSTETLVPEIEDSKPSED--KMEVEELPVAENGEKEGSPEK----------CSDAEDK 3792

  Rat  2183 KWPSNRRSQEMTTGGILGPGNHLLDSPSLTPGEYGDSPVPTPRSSSAASMVEEEASAVTTAAAQF 2247
            |:...:.|                 ||::..|:     |....:..||...||..|..:.:
  Fly  3793 KFSEEKPS-----------------SPAVPDGK-----VSEMEADEAAPNTEENCSGDSES---- 3831

  Rat  2248 TKLRRGMDEKEFTVQIKDEEGLKLTFQKHRLMANGVMGDGHPLFHKKKGNRKKLVELEVECME-E 2311
                   .|||    .:|:...|:..:|           |...:.|.:..:::..:||...:| |
  Fly  3832 -------PEKE----CEDKVVEKVEEEK-----------GENSYEKAEEQKEETEKLEKSSIESE 3874

  Rat  2312 PNH-LDVDLETRIPVINKVDG-----TLLVGDEAPRRAELDMWLQGHPEFAVDPRFLAYMEERRK 2370
            |:. .:..||..:.|..|..|     .|:.|...|...|:                   |:|:.|
  Fly  3875 PSEKSETVLEPEVAVPKKSTGDQDILDLVAGPSDPDDDEV-------------------MKEKEK 3920

  Rat  2371 QKWQRCKKNNKTELNCL--GMEPVQPANSRNGKKGH----------YAETAFNRVLPGPIA---- 2419
            ...:.||| ...||...  .:|.:|||..:..|...          :.:.|..|.:...:|
  Fly  3921 AVEEECKK-QAAELKARFPDLEVIQPATVKQQKLEKPKLEMCMIRWFKDFALERRIAHIVACVES 3984

  Rat  2420 ---PENSKKRVRRTRPDLSKMMALMQGGSTGSLSLHNTFQHSS---------------------- 2459
               |.:||          ....|..:|.:..|::||.:..|.|
  Fly  3985 GNWPVDSK----------YSAFATCKGATDLSIALHESIPHLSSLERRSTTPDVITITTDQGVTK 4039

  Rat  2460 ----SNLQSVSSLGHSSATSASLP 2479
                |::|.|:|...:::||:.:|
  Fly  4040 HLQTSHMQQVASSASAASTSSGVP 4063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chd8	XP_006251970.1	CHROMO	644..704	CDD:237991	35/271 (13%)
		Chromo	725..781	CDD:278797	32/57 (56%)
		SNF2_N	814..1101	CDD:278600	200/286 (70%)
		DEXDc	830..979	CDD:238005	94/148 (64%)
		Helicase_C	1133..1247	CDD:278689	98/113 (87%)
		BRK	2318..2362	CDD:197800	9/48 (19%)
		BRK	2387..2426	CDD:295433	11/57 (19%)
kis	NP_001137761.1	BASP1	1554..1786	CDD:283191	23/231 (10%)
		HepA	1676..2527	CDD:223627	436/854 (51%)
		SDA1	<1693..>1854	CDD:283052	0/160 (0%)
		CHROMO	<1879..1919	CDD:237991	22/39 (56%)
		Chromo	1941..1996	CDD:278797	32/54 (59%)
		DEXDc	2048..2197	CDD:238005	94/148 (64%)
		Helicase_C	2350..2464	CDD:278689	98/113 (87%)
		RR_TM4-6	3728..>3877	CDD:283990	42/208 (20%)
		BRK	4569..4613	CDD:197800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	555	1.000	Domainoid score	I234
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1547	1.000	Inparanoid score	I86
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001075
OrthoInspector	1	1.000	-	-		otm44575
orthoMCL	1	0.900	-	-		OOG6_100621
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X648
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.960