Protein Alignment PINK1 and IKS1

DIOPT Version :10

• Sequence 1: NP_115785.1
• Gene: PINK1 / 65018
• HGNCID: 14581
• Length: 581
• Species: Homo sapiens
• Sequence 2: NP_012478.3
• Gene: IKS1 / 853389
• SGDID: S000003593
• Length: 667
• Species: Saccharomyces cerevisiae
• Alignment Length: 297
• Identity: 71/297 - (23%)
• Similarity: 104/297 - (35%)
• Gaps: 122/297 - (41%)

Human   322 PC--TLRQYL-------CV---------NTPSPR--------------------LAAMMLLQLL- 347
            ||  .|:||.       |:         :|.||.                    |:...|:.::
Yeast   268 PCIFILQQYCSGGNLEDCILRKVFNRFSDTESPEERKKKFRTRKKNHGKSGEVGLSTEQLVSIIR 332

Human   348 ---EGVDHLVQQGIAHRDLKSDNILVELDP------------------DGCPWLVIADFGCCLAD 391
               .|:..|...|:.|||||..|.|: |.|                  :..|.:||.|.|
Yeast   333 DIARGLHELHSIGLIHRDLKPSNCLL-LTPFKSDNENDNVYDREHNSDEFFPSIVIGDLG----- 391

Human   392 ESIGLQLPFSSWYVDRGGNGC-----LMAPE-------VSTARPGPRAVIDYSK----ADAWAVG 440
            ||   ||...|    |.|.||     ..||:       ||::....|:...|::    :|.:::|
Yeast   392 ES---QLEGES----RLGTGCTGTLEFTAPDLIIQGRPVSSSTLPSRSSHTYNEYTFASDMYSLG 449

Human   441 AIAYEI-FGLVNPFYGQ-----GKAHLES---------RSYQEAQLPALPESVPPDVR--QLVRA 488
            .|.|.| ||.: ||..|     .|..:::         ..:|..:|.      |.|.|  .|:.|
Yeast   450 MICYFIVFGEL-PFEPQLDIVDLKVRIKNFRFDTEGMIEKHQAMKLK------PIDRRIFHLMDA 507

Human   489 LLQREASKRPSARVAANVLHLSL---------WGEHI 516
            |||.....||:|:.....|...|         |.|::
Yeast   508 LLQPNNDARPTAKTVEETLDEMLINSKPGKKFWKENV 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PINK1	NP_115785.1	Required for outer membrane localization. /evidence=ECO:0000269|PubMed:30733118	111..117
		STKc_PINK1	162..512	CDD:270920	69/291 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..208
IKS1	NP_012478.3	Protein Kinases, catalytic domain	173..522	CDD:473864	67/273 (25%)