DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PINK1 and pink1

DIOPT Version :9

Sequence 1:	NP_115785.1	Gene:	PINK1 / 65018	HGNCID:	14581	Length:	581	Species:	Homo sapiens
Sequence 2:	NP_001008628.1	Gene:	pink1 / 494085	ZFINID:	ZDB-GENE-041212-53	Length:	574	Species:	Danio rerio

Alignment Length:	604	Identity:	320/604 - (52%)
Similarity:	394/604 - (65%)	Gaps:	59/604 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAVRQALGRGLQLGRALLLRFTGKPGRAYGLGRP-GPAAGCVRGE-----RPGWAAGPGAEPRRV 59
            |:|:..|.|||:|||::.         ..||.:| |..|...|||     ||.....|..
Zfish     1 MSVKHVLSRGLELGRSVF---------QLGLLKPAGRVAAKFRGERLRVSRPTRTVQPQT----- 51

Human    60 GLGLPNRLRFFRQSVAGLAARLQRQFVVRAWGCAGPCGRAVFLAFGLGLGLIEEKQAESRRAVSA 124
              .||.|.||||.||:||||:||.....|..|......||||||||:||||||::|.|.|.:.:.
Zfish    52 --FLPGRYRFFRLSVSGLAAQLQSGAFRRVIGGGSARNRAVFLAFGVGLGLIEQEQEEDRTSAAL 114

Human   125 CQEIQAIFTQKS-KPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQNLEVTKST 188
            ||||||:|.:|. :..|.|..:    |:|||:|:||:.|||||:||||||..|..|. :| :|..
Zfish   115 CQEIQAVFRKKKFQSLPKPFTS----GYRLEDYVIGKQIGKGCNAAVYEAAAPFAPP-VE-SKKC 173

Human   189 GLLPGRGPGTSAPGEGQE--RAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQELVPA------- 244
            .|:...........:.:|  |...:|:||||:||||||.|||||:|||.:||.||||:
Zfish   174 SLVELNQKEAEDDNKKEEPLRLSASPSFPLAMKMMWNIGAGSSSDAILRSMSMELVPSCPQALRK 238

Human   245 --SRVALAGEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEG 307
              ..:.|.|.:|||        ||:|:.|||:|.|.||||:.|||||||..:||||||:||:|.|
Zfish   239 EQGELTLNGHFGAV--------PKRLSAHPNVITVYRAFTAEVPLLPGAREEYPDVLPTRLNPHG 295

Human   308 LGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVEL 372
            ||..||||||||||||||||||.|..|....|::|.||||||||||.:|.||||||||||||:|.
Zfish   296 LGSNRTLFLVMKNYPCTLRQYLEVCVPKRTQASLMFLQLLEGVDHLCRQNIAHRDLKSDNILLEF 360

Human   373 DPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVIDYSKADAW 437
            |..|||.|||.|||||||::| ||:||||||:|:||||.||||||||||.|||..||||||||.|
Zfish   361 DNTGCPRLVITDFGCCLAEDS-GLKLPFSSWWVNRGGNSCLMAPEVSTAVPGPGVVIDYSKADVW 424

Human   438 AVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSARV 502
            ||||||||:||..||||     .||||||||.||||||.:.|.||:.:|:.||::...|||||||
Zfish   425 AVGAIAYELFGQPNPFY-----TLESRSYQEKQLPALPAAAPDDVQLVVKLLLRKNPHKRPSARV 484

Human   503 AANVLHLSLWGEHIL-ALKNLKLDKMVGWLLQQSAATLLANRLTEKCCVETKMKMLFLANLECET 566
            |||:||:||||..:| .|..:::.:|:.||..|||..||..|..::..||.:::..||||:|.|.
Zfish   485 AANILHISLWGRRVLMGLDKVQMAEMMAWLQCQSAVVLLKGRGRDQSSVEAELQRSFLANIELED 549

Human   567 LCQAALLLC----SWRAAL 581
            |..|...:.    .||:.|
Zfish   550 LRTAVSFMTYERKQWRSLL 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PINK1	NP_115785.1	Required for outer membrane localization. /evidence=ECO:0000269\|PubMed:30733118	111..117		3/5 (60%)
		STKc_PINK1	162..512	CDD:270920	222/360 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..208		2/20 (10%)
pink1	NP_001008628.1	STKc_PINK1	149..494	CDD:270920	222/360 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194329611
Domainoid	1	1.000	328	1.000	Domainoid score	I6526
eggNOG	1	0.900	-	-		E1_KOG4158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32672
Inparanoid	1	1.050	549	1.000	Inparanoid score	I5906
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41021
OrthoDB	1	1.010	-	-		D137670at7742
OrthoFinder	1	1.000	-	-		FOG0008271
OrthoInspector	1	1.000	-	-		oto49055
orthoMCL	1	0.900	-	-		OOG6_109238
Panther	1	1.100	-	-	LDO	PTHR22972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2724
SonicParanoid	1	1.000	-	-		X7349
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300