DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PINK1 and Pink1

DIOPT Version :9

Sequence 1:	NP_115785.1	Gene:	PINK1 / 65018	HGNCID:	14581	Length:	581	Species:	Homo sapiens
Sequence 2:	NP_001027049.1	Gene:	Pink1 / 31607	FlyBaseID:	FBgn0029891	Length:	721	Species:	Drosophila melanogaster

Alignment Length:	740	Identity:	217/740 - (29%)
Similarity:	310/740 - (41%)	Gaps:	199/740 - (26%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAVRQALGRGLQLGRALLLRFTGKPGRA-------------YGLGRPGPAAGCVRGERPGWAA-- 50
            |:||....|.::.||.:|..:..:...|             .|...|..||..:| ..|..||
  Fly     1 MSVRLLTVRLIKHGRYILRSYCKRDIHANILDQNQLKTRSKRGFPLPSTAANVLR-TTPQQAAKS 64

Human    51 ------------------GPGAEPR------RVG-----LGLPNRL-RFFRQSVAGLAARLQRQF 85
                              |.|:.|.      |||     |.:.|.| |........|..|..|:.
  Fly    65 VVNVVPRTINSPSGSPFNGSGSSPTSSSGIFRVGQHARKLFIDNILSRVTTTYSEDLRQRATRKL 129

Human    86 VVRAWGCAGPCGRAVFLAFGLGLGLIEEKQA------ESRRAVSACQ------EIQAIFTQKSKP 138
            .   :|.:.|....:.::...|.|::.::..      |.|.|.|..|      ||.
  Fly   130 F---FGDSAPFFALIGVSLASGSGVLSKEDELEGVCWEIREAASRLQNAWNHDEIS--------- 182

Human   139 GPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEA----TMPTLPQNLEVTKSTGLLPGRGPGT- 198
              |.||::    |.:::..||..|.|||:|.||.|    .:.:...:|.........|...|.:
  Fly   183 --DTLDSK----FTIDDLEIGPPIAKGCAAVVYAADFKKDVASDGASLHTDAQPQATPAFAPNSW 241

Human   199 -----------------------------SAPG-----------------------------EGQ 205
                                         |.|.                             :.|
  Fly   242 STHEMMSPLQNMSRFVHNFGGSVDNVFHYSQPSAASDFVGAQSREQDQRHHEQQQHQNQEQEQHQ 306

Human   206 ERAPGAPAF-----------------PLAIKMMWNISAGSSSEAILNTMSQELVPASRVAL---A 250
            .:.|.:.||                 |||:|||:|....|::.:||..|.:|.|||.:..:   |
  Fly   307 NQEPSSSAFNVTSPANSNINSSVDSYPLALKMMFNYDIQSNALSILRAMYKETVPARQRGMNEAA 371

Human   251 GEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLF 315
            .|:..:...::...|:    ||||:.:...|...|...|...:.||...|.|::|:|.|...:|:
  Fly   372 DEWERLLQNQTVHLPR----HPNIVCMFGFFCDEVRNFPDGHLLYPVAQPQRINPQGYGRNMSLY 432

Human   316 LVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWL 380
            |:||.|..:||..|.....|.|...::|.|:||.|:||.:.|:|||||||||:|:||..|..|.|
  Fly   433 LLMKRYDHSLRGLLDSQDLSTRNRILLLAQMLEAVNHLSRHGVAHRDLKSDNVLIELQDDAAPVL 497

Human   381 VIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVIDYSKADAWAVGAIAYE 445
            |::||||||||:..||:||:.|..||:|||..|||||:....|||.||::|.|||.||.||:|||
  Fly   498 VLSDFGCCLADKVHGLRLPYVSHDVDKGGNAALMAPEIFNTMPGPFAVLNYGKADLWACGALAYE 562

Human   446 IFGLVNPFY----------GQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREASKRPSA 500
            |||..||||          |:....|.:..|::.|||.:.::.||.::|||..:|....|||.|.
  Fly   563 IFGNRNPFYSSSGGMARERGEMTLSLRNSDYRQDQLPPMSDACPPLLQQLVYNILNPNPSKRVSP 627

Human   501 RVAANVLHLSLWGEHILALKN-LKLDKM------VGWLLQQSAATLLANRLTEKCCVETKMKM-- 556
            .:||||:.|.||     |..| ||...|      :.|||.          ||.|...|.:.:|
  Fly   628 DIAANVVQLFLW-----APSNWLKAGGMPNSPEILQWLLS----------LTTKIMCEGRPQMGA 677

Human   557 --LFLANLECETLCQAALLLCSWRA 579
              :.:|:..........||:||:.|
  Fly   678 GLMPVASCGNRRAYVEYLLICSFLA 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PINK1	NP_115785.1	Required for outer membrane localization. /evidence=ECO:0000269\|PubMed:30733118	111..117		0/11 (0%)
		STKc_PINK1	162..512	CDD:270920	150/442 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..208		5/77 (6%)
Pink1	NP_001027049.1	STKc_PINK1	328..639	CDD:270920	133/314 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147045
Domainoid	1	1.000	212	1.000	Domainoid score	I2792
eggNOG	1	0.900	-	-		E1_KOG4158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D161355at33208
OrthoFinder	1	1.000	-	-		FOG0008271
OrthoInspector	1	1.000	-	-		oto89559
orthoMCL	1	0.900	-	-		OOG6_109238
Panther	1	1.100	-	-	LDO	PTHR22972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2724
SonicParanoid	1	1.000	-	-		X7349
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.740