DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PINK1 and Pink1

DIOPT Version :9

Sequence 1:	NP_115785.1	Gene:	PINK1 / 65018	HGNCID:	14581	Length:	581	Species:	Homo sapiens
Sequence 2:	NP_001100164.1	Gene:	Pink1 / 298575	RGDID:	1305769	Length:	257	Species:	Rattus norvegicus

Alignment Length:	241	Identity:	189/241 - (78%)
Similarity:	204/241 - (84%)	Gaps:	1/241 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAVRQALGRGLQLGRALLLRFTGKPGRAYGLGRPGPAAGCVRGERPGWAAGPGAEPRRVGLGLPN 65
            |||||||||||||||||||||..|||...|.|:|||.|...||||||..:.|||:||.:||.||:
  Rat     1 MAVRQALGRGLQLGRALLLRFAPKPGPVSGWGKPGPGAAWGRGERPGRVSSPGAQPRPLGLPLPD 65

Human    66 RLRFFRQSVAGLAARLQRQFVVRAWGCAGPCGRAVFLAFGLGLGLIEEKQAESRRAVSACQEIQA 130
            |.|||||||||||||:||||||||.|.|||||||||||||||||||||||||||||.||||||||
  Rat    66 RYRFFRQSVAGLAARIQRQFVVRARGGAGPCGRAVFLAFGLGLGLIEEKQAESRRAASACQEIQA 130

Human   131 IFTQKSKPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQNLEVTKSTGLLPGRG 195
            |||||:|...|||||||.||||||:|||||:|||||:|||||||||||||:||..|..||| |:|
  Rat   131 IFTQKNKQVSDPLDTRRWQGFRLEDYLIGQAIGKGCNAAVYEATMPTLPQHLEKAKHLGLL-GKG 194

Human   196 PGTSAPGEGQERAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQEL 241
            |...:.|...|:||||||||.||||||||||||||||||:.|||||
  Rat   195 PDVVSKGADGEQAPGAPAFPFAIKMMWNISAGSSSEAILSKMSQEL 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PINK1	NP_115785.1	Required for outer membrane localization. /evidence=ECO:0000269\|PubMed:30733118	111..117		5/5 (100%)
		STKc_PINK1	162..512	CDD:270920	60/80 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..208		8/18 (44%)
Pink1	NP_001100164.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..60		17/31 (55%)
		Required for outer membrane localization. /evidence=ECO:0000250\|UniProtKB:Q9BXM7	111..117		5/5 (100%)
		PKc_like	162..>240	CDD:304357	58/78 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83682070
Domainoid	1	1.000	411	1.000	Domainoid score	I10397
eggNOG	1	0.900	-	-		E1_KOG4158
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32672
Inparanoid	1	1.050	942	1.000	Inparanoid score	I5947
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41021
OrthoDB	1	1.010	-	-		D124353at32523
OrthoFinder	1	1.000	-	-		FOG0008271
OrthoInspector	1	1.000	-	-		oto130720
orthoMCL	1	0.900	-	-		OOG6_109238
Panther	1	1.100	-	-	LDO	PTHR22972
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X7349
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310