Protein Alignment PINK1 and hri2

DIOPT Version :10

• Sequence 1: NP_115785.1
• Gene: PINK1 / 65018
• HGNCID: 14581
• Length: 581
• Species: Homo sapiens
• Sequence 2: NP_593146.1
• Gene: hri2 / 2541943
• PomBaseID: SPAC222.07C
• Length: 639
• Species: Schizosaccharomyces pombe
• Alignment Length: 622
• Identity: 118/622 - (18%)
• Similarity: 197/622 - (31%)
• Gaps: 245/622 - (39%)

Human   108 LGLIEEKQAESRRAVSA----------CQEIQAIFTQKSKPG----PDPLDTRRLQGFRLEEYLI 158
            :|::||:..|...||.:          .|..:||....::..    |||  |...:.|..|..|.
pombe    75 IGILEEEYIEELAAVRSNYQDALHHLILQAREAIRLDDAEERLLALPDP--TNVFEKFPQETALS 137

Human   159 GQSIGKGCSAAVYEATMPTLPQNLEVTKSTGL-------LPGRGPGTSAPGEGQERAPGAPAFPL 216
            ..|: .|.:...:.....||...|:...|..:       |.||| |..:....:.:..||   ..
pombe   138 KFSV-DGLNVRQFRFRDLTLESWLQSRNSRYIEDFEEYSLLGRG-GFGSVYHVRNKIDGA---EY 197

Human   217 AIKMMWNISAGSSSEAILNTMSQELVPASRVALAGEYGAVTYRKSKRGPKQLA--PHPNIIRVLR 279
            |:|.             :|:..|::               :|.|..|..|.||  .|||:||...
pombe   198 AMKK-------------INSTFQQM---------------SYSKIFREIKCLAKMDHPNVIRYFS 234

Human   280 AFTSSV-----------------------------------PLLPGALVDYPDVL---------- 299
            ::..|.                                   |....||.|  |:|
pombe   235 SWVESTTEATQMPIVMSKNSSRVLGTSSYCDVNGMDSIIFEPTESSALTD--DILFAEDPGTESI 297

Human   300 -----------------------PSRLHPE------------------------GLGHGRTLFLV 317
                                   |..||..                        |..|...:::.
pombe   298 ISTSRKSSYSSTTESSNFENLESPRNLHDSNVSTFNNTTILDDDYSSSMHISKTGPTHSFIIYIQ 362

Human   318 MKNYPCTLRQY-----------LC-----VNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKSD 366
            |:.....|..|           ||     ::|...|:....::.:.|||:      :.|||:|..
pombe   363 MQLCFDDLESYLIRRNHFLSFPLCKEQIQLHTDLFRMIINGVMYVHEGVN------LIHRDIKPS 421

Human   367 NILV--ELDPD-GCPWLV---------------IADFGCCLADESIGLQLPFSSWYVDRG----- 408
            ||.:  .|..| |...|:               |.|||..:.::. ..:...|  :::|.
pombe   422 NIFLAKSLPEDRGSVPLISYNDKNDLKEYITPKIGDFGLVVENKK-NTETALS--FLERNHLPNL 483

Human   409 -------GNGCLMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLE-SRS 465
                   |.....|||:..|......... .|.|.:::|.:.:|   |::||    :.::| :..
pombe   484 QDETQHIGTATYAAPELLDAMSSQHNKFT-KKIDTFSLGMVLFE---LLHPF----QTNMERATK 540

Human   466 YQEAQLPALPESVPPDVRQ------LVRALLQREASKRPSARVAANVLHLSLWGEHILALKNLKL 524
            .|:.:...|||..   |.|      |:..:..::.:||||   ...||:..|...:.:::.|:
pombe   541 LQDLRRGNLPEEF---VEQHICESSLILWMTAKDPTKRPS---LLEVLNCGLLLPNQVSMPNI-- 597

Human   525 DKMVGWLLQQSAATLLANRLTEKCCVETKMKMLFLAN 561
                       :..:..|.|.    |||:||::...|
pombe   598 -----------SNIVSTNHLD----VETQMKLIMDEN 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PINK1	NP_115785.1	Required for outer membrane localization. /evidence=ECO:0000269|PubMed:30733118	111..117		2/5 (40%)
		STKc_PINK1	162..512	CDD:270920	91/503 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..208		5/25 (20%)
hri2	NP_593146.1	STKc_EIF2AK	164..585	CDD:270898	87/477 (18%)