DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PINK1 and pink-1

DIOPT Version :9

Sequence 1:	NP_115785.1	Gene:	PINK1 / 65018	HGNCID:	14581	Length:	581	Species:	Homo sapiens
Sequence 2:	NP_495017.1	Gene:	pink-1 / 173918	WormBaseID:	WBGene00017137	Length:	641	Species:	Caenorhabditis elegans

Alignment Length:	500	Identity:	158/500 - (31%)
Similarity:	248/500 - (49%)	Gaps:	72/500 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   117 ESRRAVSACQEIQAIFTQKSKPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQN 181
            |..|.|...:.|:.||....:...|...|....  |::.|..|:.:|:||:||||.|.:..  .:
Worm   100 ELPRNVDLVERIRQIFGNSLRYNEDLKSTEWPN--RIDSYEFGEFLGQGCNAAVYSARLAN--SD 160

Human   182 LEVTKSTGLLPGRGPGTSAPGE-------GQERAPGAPAFPLAIKMMWNISAGSSSEA-ILNTMS 238
            .|.:.:|....|....|:...|       .|::      ||||||:|:|.......:| :|.:|.
Worm   161 AESSGNTHYGAGFNEVTNILAEIPPVSKVAQKK------FPLAIKLMFNFEHDRDGDAHLLKSMG 219

Human   239 QELVPASRVA--LAGEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVL-P 300
            .||.|....|  |.|:.|  |:|...      |.|||::|:..||..|:.:||.|:..|||.| .
Worm   220 NELAPYPNAAKLLNGQMG--TFRPLP------AKHPNVVRIQTAFIDSLKVLPDAIERYPDALHT 276

Human   301 SRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAHRDLKS 365
            :|.:.......:|:::||:.|..||.:|:.....:.....:::.||||...:|.:..:|.||:||
Worm   277 ARWYESIASEPKTMYVVMRRYRQTLHEYVWTRHRNYWTGRVIIAQLLEACTYLHKHKVAQRDMKS 341

Human   366 DNILVELD-PDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVI 429
            ||||:|.| .|..|.||:|||||.||.::  .|:.:.|..|..|||....|||::||.||....:
Worm   342 DNILLEYDFDDEIPQLVVADFGCALACDN--WQVDYESDEVSLGGNAKTKAPEIATAVPGKNVKV 404

Human   430 DYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPPDVRQLVRALLQREA 494
            ::..||.||.|.::||:....||||    ..|::.:|||::|||||..|....|.::..||:|:.
Worm   405 NFEMADTWAAGGLSYEVLTRSNPFY----KLLDTATYQESELPALPSRVNFVARDVIFDLLKRDP 465

Human   495 SKRPSARVAANVLHLSLW--GE----------------------HILALK-NLKLDKMVGWLLQQ 534
            ::|....:|||.|:|||:  ||                      .:|:.| |.:|||::..:..:
Worm   466 NERVKPNIAANALNLSLFRMGEDVKQMMEKCGISQMTTLLAGSSKVLSQKINSRLDKVMNLITAE 530

Human   535 SAATLLANRLTEKCCVETKMKMLFLANLECETLCQAALLLCSWRA 579
            :....||..|..:  .|.:::..||:.:..|.:         ||:
Worm   531 TIMANLAPHLISR--AERQLRATFLSRMNREDI---------WRS 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PINK1	NP_115785.1	Required for outer membrane localization. /evidence=ECO:0000269\|PubMed:30733118	111..117		158/499 (32%)
		STKc_PINK1	162..512	CDD:270920	129/361 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..208		4/25 (16%)
pink-1	NP_495017.1	S_TKc	137..468	CDD:214567	124/352 (35%)
pink-1	NP_495017.1	STKc_PINK1	143..483	CDD:270920	129/361 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161453991
Domainoid	1	1.000	157	1.000	Domainoid score	I2832
eggNOG	1	0.900	-	-		E1_KOG4158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32672
Inparanoid	1	1.050	205	1.000	Inparanoid score	I2774
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008271
OrthoInspector	1	1.000	-	-		oto22148
orthoMCL	1	0.900	-	-		OOG6_109238
Panther	1	1.100	-	-	LDO	PTHR22972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2724
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.820