DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PINK1 and prag1

DIOPT Version :9

Sequence 1:	NP_115785.1	Gene:	PINK1 / 65018	HGNCID:	14581	Length:	581	Species:	Homo sapiens
Sequence 2:	XP_002936500.1	Gene:	prag1 / 100486686	XenbaseID:	XB-GENE-5933625	Length:	1294	Species:	Xenopus tropicalis

Alignment Length:	289	Identity:	72/289 - (24%)
Similarity:	114/289 - (39%)	Gaps:	80/289 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   268 LAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHG----------------RTLFL 316
            |..|.||.:....|.::||             .|.|||..:..|                ..:.:
Frog   968 LPVHFNIQQDCGNFVATVP-------------SSMLHPPNIPKGPSSNESSQTVGPASEQECVVV 1019

Human   317 VMKNYP-CTLRQYL----CVNTPSP----RLAAMMLLQLLEGVDHLVQQGIAHRDLKSDNILV-- 370
            :.:..| .|..:::    ..:...|    |...::||||..|::||.:.||.||||..:|:|:
Frog  1020 ITREVPYLTAAEFVEESGSTHQLQPEVYERQVCLLLLQLCNGLEHLKEHGIIHRDLCLENLLLVH 1084

Human   371 -ELDPDG------CPWLVIADF-------GCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVSTA 421
             :..|:.      .|.|::::|       ||   :||...:            :...:|||:..|
Frog  1085 WQNSPEKIKDVKYVPRLIVSNFSKAKQRSGC---EESKPRR------------DKTRLAPEIMAA 1134

Human   422 RPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPE-SV-PPDVRQ 484
            .       .|.|.|.:..|.:.||:....|||  :.:|.|....|.:..||:||. || ...::.
Frog  1135 S-------QYKKFDEFQTGILIYELLHQPNPF--EVRASLHEHDYSQKDLPSLPALSVYSRGLQH 1190

Human   485 LVRALLQREASKRPSARVAANVLHLSLWG 513
            |...||:.:..||.....|..||...|||
Frog  1191 LAHLLLEADPIKRIRISEAKRVLQCLLWG 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PINK1	NP_115785.1	Required for outer membrane localization. /evidence=ECO:0000269\|PubMed:30733118	111..117
		STKc_PINK1	162..512	CDD:270920	69/286 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..208
prag1	XP_002936500.1	PKc_like	<1061..1218	CDD:389743	49/180 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910