Protein Alignment BMP2 and scw

DIOPT Version :10

• Sequence 1: NP_001191.1
• Gene: BMP2 / 650
• HGNCID: 1069
• Length: 396
• Species: Homo sapiens
• Sequence 2: NP_524863.3
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Alignment Length: 408
• Identity: 98/408 - (24%)
• Similarity: 164/408 - (40%)
• Gaps: 106/408 - (25%)

Human    50 LSEFELRLLSMFGLKQRP----TPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAA------- 103
            ||| ::.::.:..|..||    .|:.......::|::|...|.........|:..:.:
  Fly    36 LSE-QMEMIDILDLGDRPRRQAEPNLHNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLDDDILI 99

Human   104 --------SRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDA 160
                    :..|::.:|......|:|   ..:......||.:.:|.:..:..|.|:::::..
  Fly   100 SNEDRQEIASCNSILTFSSRLKPEQL---DNELDMHITFNTNDVPVDLSLVQAMLRIYKQPS--- 158

Human   161 LGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTR---------LVNQNASR--WESFDVTPAVM 214
                            :....||....|.|.||.|         .||..:|:  |..|::|..:.
  Fly   159 ----------------LVDRRANFTVSVYRKLDNRQDFSYRILGSVNTTSSQRGWLEFNLTDTLR 207

Human   215 RWTAQGHANHGFVVEVAHLEEKQGVSKRH-VRIS----------RSLHQDEHSWSQIRPLLVTFG 268
            .|.                 ..:|:.:|: :|||          ..|...:.|.:.:.|.:|  |
  Fly   208 YWL-----------------HNKGLQRRNELRISIGDSQLSTFAAGLVTPQASRTSLEPFIV--G 253

Human   269 HDGKGHPLHKREKRQAKHKQRKRL-------------------KSSCKRHPLYVDFSDVGWNDWI 314
            :......|.|.:|.:.|....||.                   ..||:|....|||.::..::|:
  Fly   254 YFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDLYRPPQSCERLNFTVDFKELHMHNWV 318

Human   315 VAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISML-YLDENE 378
            :||..:.|::|.|.|.|||...:|:|||||||||::.....:||.|||||.|.||::| ||  ||
  Fly   319 IAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPHLPKPCCVPTVLGAITILRYL--NE 381

Human   379 KVV-LKNYQDMVVEGCGC 395
            .:: |..||..|.:.|||
  Fly   382 DIIDLTKYQKAVAKECGC 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP2	NP_001191.1	TGF_beta_BMP2	294..396	CDD:381660	48/104 (46%)
		TGFb_propeptide	52..267	CDD:459906	41/255 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..121		5/51 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..293		6/40 (15%)
scw	NP_524863.3	TGFb_propeptide	39..254	CDD:480997	40/255 (16%)
		TGF_beta_BMP5_like	299..400	CDD:381639	48/103 (47%)