Protein Alignment BMP2 and myo

DIOPT Version :10

• Sequence 1: NP_001191.1
• Gene: BMP2 / 650
• HGNCID: 1069
• Length: 396
• Species: Homo sapiens
• Sequence 2: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Alignment Length: 428
• Identity: 88/428 - (20%)
• Similarity: 161/428 - (37%)
• Gaps: 119/428 - (27%)

Human    50 LSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVR---- 110
            :...::.:|....||:.|..::...||..::|.:.|...........:|:|.......::.
  Fly   207 IESIKMHILMRLNLKKLPNITKPISVPQNIIDNFYRDYNASSKTTVWNRMESIDESHLSINDTYG 271

Human   111 -----SFHHEESLEELPETSGKTTRRFFFNL-------SSIP----TEEF--ITS--AELQVFRE 155
                 .|..|.|..::......|...|..:|       |.||    .||:  |.|  :.:.:|.|
  Fly   272 DHIMTDFFDESSSSQMQGDDANTVNEFLIDLNKNQAKKSDIPINTNDEEYESILSHISSIYIFPE 336

Human   156 QMQDALGNN-------------------SSFH-----------HR----------------INIY 174
            ::|..:.:|                   ::.|           |:                :.|:
  Fly   337 EIQPHVRHNRKVDVFRFQIDSSYSDLSYATLHLYLRGWDWISAHQPGLLEEIKKQPRKDIVVTIH 401

Human   175 EIIKPATANSKFPVTRLLDTR-LVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQG 238
            ..|:.|...|..|..::.:.| .:.....:|.:.|:...:      |:.......|:
  Fly   402 RAIRVANTTSFNPKVKMFEFRHSIPSGLGQWVAVDLKSLL------GNLGSNMTQEI-------- 452

Human   239 VSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPL--HKREKRQAKHKQRKRLKSSCK---- 297
                       |.:...:|  ::.|:||..:..| :||  |.....|.||::::.:...|.
  Fly   453 -----------LIKGAETW--MKSLVVTTDNTSK-NPLTVHIEIGSQKKHRRKRSVYMDCTENDH 503

Human   298 -----RHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIP 357
                 |:||.|:|:..||: ::|||..:.|::|.|:|.   ..:|....|..:..|..|..
  Fly   504 DMRCCRYPLKVNFTSFGWH-FVVAPTSFDAYFCSGDCK---VGYLEQYPHTHLAALTTSAT---- 560

Human   358 KACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC 395
             .||.||::|::|:||.|:|..:||....:|.||||.|
  Fly   561 -PCCSPTKMSSLSLLYFDDNHNLVLSVIPNMSVEGCSC 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP2	NP_001191.1	TGF_beta_BMP2	294..396	CDD:381660	37/111 (33%)
		TGFb_propeptide	52..267	CDD:459906	43/285 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..121		6/45 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..293		7/23 (30%)
myo	NP_726604.1	TGF_beta_GDF8_like	506..597	CDD:381629	35/99 (35%)