Protein Alignment BMP2 and mav

DIOPT Version :10

• Sequence 1: NP_001191.1
• Gene: BMP2 / 650
• HGNCID: 1069
• Length: 396
• Species: Homo sapiens
• Sequence 2: NP_524626.1
• Gene: mav / 43804
• FlyBaseID: FBgn0039914
• Length: 701
• Species: Drosophila melanogaster
• Alignment Length: 273
• Identity: 70/273 - (25%)
• Similarity: 124/273 - (45%)
• Gaps: 54/273 - (19%)

Human   164 NSSFHHRINIYEIIKPATANSKFPVT-RLLDTRLV--NQNASRWESFDVTPAVMRWTAQGHANHG 225
            |||....:.:|:::   :||.:..:| |.::...|  .:..::|..||||.||..|..:.|.|.|
  Fly   441 NSSQQLTLKVYQLL---SANRRRKITSRKIEFGNVGFQETRTQWIEFDVTKAVRSWLNKSHENLG 502

Human   226 FVVEVAHLEEKQGVSKRHV---------RISRSLHQDEHSWSQIRPLLVTFGH---------DGK 272
            ..::   .::.:.:..|.:         |.:.|  .|||  ..:.|:|...||         |..
  Fly   503 IEIQ---CDKCKSIGARILSDFSPSTPPRSTAS--SDEH--LNLMPVLNIIGHGTLNSQQHGDAD 560

Human   273 GHPL-----------HKREKRQAKHKQRK------RLKSSCKRHPLYVDFSDVGWNDWIVAPPGY 320
            .|.:           |.|....:..::.|      :|...|.|:.|.|.|..:...::|:.|..:
  Fly   561 IHQIMLTNNRSDQYVHHRSNHDSTWRKDKWTNNCYKLHQRCCRNQLDVAFKSIKGFEFILQPKVF 625

Human   321 HAFYCHGECPFPLADHLNSTNHAIVQTLV-NSVNSKIPKACCVPTELSAISMLYLDEN--EKVVL 382
            .|.||||.||   ..|..:.:||::|:|: ...:.:.|:.||.|::|..:.:|::|||  :|:.:
  Fly   626 DAGYCHGRCP---PRHNPAHHHALLQSLIWQEDHKRAPRPCCTPSKLEMLEILHVDENHSDKLKI 687

Human   383 KNYQDMVVEGCGC 395
            ..:.||.|..|.|
  Fly   688 STWSDMQVVECAC 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP2	NP_001191.1	TGF_beta_BMP2	294..396	CDD:381660	34/105 (32%)
		TGFb_propeptide	52..267	CDD:459906	28/114 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..121
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..293		4/38 (11%)
mav	NP_524626.1	TGFb_propeptide	<438..518	CDD:480997	21/82 (26%)
		TGF_beta_maverick	598..700	CDD:381633	33/104 (32%)