Protein Alignment BMP2 and gbb

DIOPT Version :10

• Sequence 1: NP_001191.1
• Gene: BMP2 / 650
• HGNCID: 1069
• Length: 396
• Species: Homo sapiens
• Sequence 2: NP_477340.1
• Gene: gbb / 37778
• FlyBaseID: FBgn0024234
• Length: 455
• Species: Drosophila melanogaster
• Alignment Length: 478
• Identity: 142/478 - (29%)
• Similarity: 211/478 - (44%)
• Gaps: 127/478 - (26%)

Human     8 LLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDE-----VLSE-----FELRLLSMFG 62
            |.:|.|..|||...|...|.:     .|..||.......|:     ||||     ....:|...|
  Fly    14 LASLGLGMVLLMFVATTPPAV-----EATQSGIYIDNGKDQTIMHRVLSEDDKLDVSYEILEFLG 73

Human    63 LKQRPTP------SRDAVVPPYMLDLYRRHSGQPGSPAPD--------HRLERAA---------- 103
            :.:|||.      |.....|.::||:|.|.:.:.|....|        ||..|:|
  Fly    74 IAERPTHLSSHQLSLRKSAPKFLLDVYHRITAEEGLSDQDEDDDYERGHRSRRSADLEEDEGEQQ 138

Human   104 ------------SRANTVRSF----HHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQV 152
                        ..::.:.:|    ||  :::||....|   ||.:|::|::|.:.::..|||::
  Fly   139 KNFITDLDKRAIDESDIIMTFLNKRHH--NVDELRHEHG---RRLWFDVSNVPNDNYLVMAELRI 198

Human   153 FREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVT-RLLDTRLVNQNASR------------- 203
            ::...:.                  |..|||.:|.:| ..:.|..:.|:...
  Fly   199 YQNANEG------------------KWLTANREFTITVYAIGTGTLGQHTMEPLSSVNTTGDYVG 245

Human   204 WESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRIS--RSLHQ--DEHSWSQIRPLL 264
            |...:||..:..|..:...|||..:. ||...:   ..|.|::.  ..:|:  |:    :.:|.:
  Fly   246 WLELNVTEGLHEWLVKSKDNHGIYIG-AHAVNR---PDREVKLDDIGLIHRKVDD----EFQPFM 302

Human   265 VTF--GHD---GKGHPLHKREKRQAKHKQRKRLKS----------------SCKRHPLYVDFSDV 308
            :.|  |.:   ...|..|.|.||.|.| .|||.||                ||:...||:||.|:
  Fly   303 IGFFRGPELIKATAHSSHHRSKRSASH-PRKRKKSVSPNNVPLLEPMESTRSCQMQTLYIDFKDL 366

Human   309 GWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAISML 372
            ||:|||:||.||.||||.|||.|||..|:|:||||||||||:.:. .|:||.||.||.|.|:.:|
  Fly   367 GWHDWIIAPEGYGAFYCSGECNFPLNAHMNATNHAIVQTLVHLLEPKKVPKPCCAPTRLGALPVL 431

Human   373 YLDENEKVVLKNYQDMVVEGCGC 395
            |...:|.|.||.|::|:|:.|||
  Fly   432 YHLNDENVNLKKYRNMIVKSCGC 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP2	NP_001191.1	TGF_beta_BMP2	294..396	CDD:381660	60/119 (50%)
		TGFb_propeptide	52..267	CDD:459906	54/277 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..121		10/70 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..293		10/21 (48%)
gbb	NP_477340.1	TGFb_propeptide	45..305	CDD:459906	58/290 (20%)
		TGF_beta_BMP5_like	353..455	CDD:381639	59/102 (58%)