Protein Alignment BMP2 and daw

DIOPT Version :10

• Sequence 1: NP_001191.1
• Gene: BMP2 / 650
• HGNCID: 1069
• Length: 396
• Species: Homo sapiens
• Sequence 2: NP_523461.1
• Gene: daw / 33474
• FlyBaseID: FBgn0031461
• Length: 586
• Species: Drosophila melanogaster
• Alignment Length: 412
• Identity: 93/412 - (22%)
• Similarity: 172/412 - (41%)
• Gaps: 76/412 - (18%)

Human    26 PE--LGRRKFA----AASSGRPSSQPSDEV--LSEFEL----------RLLSMFGLKQRPTPSRD 72
            ||  ||.|...    :::.|.|..:.:.:|  ::|.:|          ::|....||:.|..|..
  Fly   210 PELPLGERNITISVKSSAGGCPKCESNRQVEHITEEQLTHLRIEFVKQQILEKLRLKESPKVSAV 274

Human    73 AVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKT--TRRFFFN 135
            .:..|....:...|   |.....:..|:...:|.:......:.|.:|......||:  :..|.|.
  Fly   275 ELPKPIFDGMTLSH---PDDSTKNKELDDYYARTSKKFILLNREEVECNRARDGKSNPSMCFTFK 336

Human   136 LSSIPTEEF-ITSAELQVFREQM---QDALGNNSSFHHRINIYEIIKPATANSKF-PVTRLLDTR 195
            :.....|.| :::|.|.:|:.:.   ..|..|::|....|.:.|:......:||: ...:.:..:
  Fly   337 IDDADAEGFDVSTAVLWLFKNKQNRTDTASVNSTSAQQTIVVSEVEVDQQKDSKYLSAAKTIAIQ 401

Human   196 LVNQNASRWESFDVTPAVMRWTAQGHANHGFVV-----EVAHLEEKQGVSKRHVRISRSLHQDEH 255
            .||.. ..|...|:...:..|.:....:|...:     :|:.:||...|.|.:
  Fly   402 SVNVQ-DEWMKIDIEWPIKHWISGHELSHLIQITCGGCDVSDMEEIISVDKDY------------ 453

Human   256 SWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSS-----CKRHPLYVDFSDVGWNDWIV 315
                 ||.:|.           ..:.|:.|.:|::.:..|     |.|..||:.|.|:||::||:
  Fly   454 -----RPFIVI-----------DMQNRRRKSRQKRSINCSSGMTECCREHLYISFRDIGWSNWIL 502

Human   316 APPGYHAFYCHGECPFPLADHLNSTNH--AIVQTLVNSVNSK----IPKACCVPTELSAISMLYL 374
            .|.||:|::|.|.|. .:|....:.:|  :|::.|..|..:|    :|  ||...:.|::.::.:
  Fly   503 KPEGYNAYFCRGSCS-SVASVTQAASHHSSIMKILSTSGANKSLELVP--CCTAKQYSSLQLVVM 564

Human   375 DENEKVVLKNYQDMVVEGCGCR 396
            |.:....:|...:||||.||||
  Fly   565 DSSNTATVKTLPNMVVESCGCR 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP2	NP_001191.1	TGF_beta_BMP2	294..396	CDD:381660	36/112 (32%)
		TGFb_propeptide	52..267	CDD:459906	44/236 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..121		6/36 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..293		3/21 (14%)
daw	NP_523461.1	TGF_beta_INHB	483..585	CDD:381630	34/104 (33%)