Protein Alignment BMP2 and dpp

DIOPT Version :10

• Sequence 1: NP_001191.1
• Gene: BMP2 / 650
• HGNCID: 1069
• Length: 396
• Species: Homo sapiens
• Sequence 2: NP_477311.1
• Gene: dpp / 33432
• FlyBaseID: FBgn0000490
• Length: 588
• Species: Drosophila melanogaster
• Alignment Length: 416
• Identity: 164/416 - (39%)
• Similarity: 227/416 - (54%)
• Gaps: 61/416 - (14%)

Human    21 AAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRD-AVVPPYMLDLYR 84
            |..::.|.|...::..:..:...:|....|.|.|..|||:|.:|:.|...|. .::|..|..||.
  Fly   194 AKAIIAEQGPSTYSKEALIKDKLKPDPSTLVEIEKSLLSLFNMKRPPKIDRSKIIIPEPMKKLYA 258

Human    85 RHSGQPGSPAPDHRLERA--------ASRANTVRSFHHEESLEELPETSGKTTRRF--------F 133
            ...|        |.|:..        ...|||||||.|::|         |...||        .
  Fly   259 EIMG--------HELDSVNIPKPGLLTKSANTVRSFTHKDS---------KIDDRFPHHHRFRLH 306

Human   134 FNLSSIPTEEFITSAELQVFREQM-QDALGNNSSFH---HRINIYEIIKPATANSKFPVTRLLDT 194
            |::.|||.:|.:.:||||:.|:.: |..:.:.||.:   :::.:|:|.:......:.|...||||
  Fly   307 FDVKSIPADEKLKAAELQLTRDALSQQVVASRSSANRTRYQVLVYDITRVGVRGQREPSYLLLDT 371

Human   195 RLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQ 259
            :.|..|::...|.||.|||.||.|....|:|.:|||..:...:.....|||:.||..:....|..
  Fly   372 KTVRLNSTDTVSLDVQPAVDRWLASPQRNYGLLVEVRTVRSLKPAPHHHVRLRRSADEAHERWQH 436

Human   260 IRPLLVTFGHDGKGHPLHK-----------------REKRQAKH-KQRKRLKSSCKRHPLYVDFS 306
            .:|||.|:..||:    ||                 |.|||.:. .:||....:|:||.||||||
  Fly   437 KQPLLFTYTDDGR----HKARSIRDVSGGEGGGKGGRNKRQPRRPTRRKNHDDTCRRHSLYVDFS 497

Human   307 DVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVN-SKIPKACCVPTELSAIS 370
            ||||:||||||.||.|:||||:||||||||.||||||:||||||::| .|:||||||||:|.:::
  Fly   498 DVGWDDWIVAPLGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNMNPGKVPKACCVPTQLDSVA 562

Human   371 MLYLDENEKVVLKNYQDMVVEGCGCR 396
            ||||::...|||||||:|.|.|||||
  Fly   563 MLYLNDQSTVVLKNYQEMTVVGCGCR 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BMP2	NP_001191.1	TGF_beta_BMP2	294..396	CDD:381660	73/102 (72%)
		TGFb_propeptide	52..267	CDD:459906	73/235 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..121		12/44 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..293		9/39 (23%)
dpp	NP_477311.1	TGFb_propeptide	225..444	CDD:480997	73/235 (31%)
		TGF_beta_DPP	480..588	CDD:381662	75/107 (70%)