Protein Alignment SKIC2 and Mtr4

DIOPT Version :10

• Sequence 1: NP_008860.4
• Gene: SKIC2 / 6499
• HGNCID: 10898
• Length: 1246
• Species: Homo sapiens
• Sequence 2: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Alignment Length: 1052
• Identity: 375/1052 - (35%)
• Similarity: 553/1052 - (52%)
• Gaps: 112/1052 - (10%)

Human   225 EDENEAVGQPGGPRGDTVSASPCSAPLARASSLEDLVLKEA-STAVSTP--EAPEPPSQEQWAIP 286
            :|:|.|..:|                 .|...::|....|| .|.:.|.  :||:..:.|..|.|
  Fly    83 DDDNNADDEP-----------------TRTLDIDDSATLEALRTRIVTHLLDAPKSCTHEVAAHP 130

Human   287 VDATSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQK 351
            .....|:..|..:   ||.::.|..|.||:||||.::...||.|:||||||||||||||||.:..
  Fly   131 DQEYIPLKPFSGV---PAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAEYAIAKSLA 192

Human   352 HMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRD 416
            ...|.|||:|||||||||||:|.:.|.||||:||||.::|.||||||||||||:|||.||:::|:
  Fly   193 AKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLYRGSEIMRE 257

Human   417 LEWVIFDEVHYINDVERGVVWEEVLIMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVISTV 481
            :.||:|||:||:.|.||||||||.||:|||:|..:.||||:|||.:||:|:..|.::..:|:.|.
  Fly   258 VGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQPCHVVYTD 322

Human   482 TRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAV-------EA-KKERMSKHAQTFGA 538
            .||.||:||:|.....    .:.|::|.:|.|....:..|:       || |.::..:|.   |.
  Fly   323 YRPTPLQHYIFPAGGD----GIHLIVDEKGQFKEDNFTTAMAVLANAGEAGKGDQKGRHG---GI 380

Human   539 KQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLF 603
            |     |..|....:: .::..:..|...||::|:||:..|:..|..:..||..|..||..:...
  Fly   381 K-----GTNAGQTNIF-KIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEV 439

Human   604 LQRCLARLRGSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMG 668
            ....:..|...||:||||.::..||.||:|:||.|:||||||.:|:||..||:|.||||||||||
  Fly   440 FNNAMDVLTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMG 504

Human   669 VNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRV-PEMADLHRM 732
            :|||||||:|.:.||.||..||.:..|||:||||||||||||..|.|||:...:| |.:.  ..:
  Fly   505 LNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPAVG--RDI 567

Human   733 MMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEF------PSRKDSKAHEQALAELTK 791
            :.||...:.|.|.|||.|:||||||:.:..|.|::|||.:|      |...|..  ||...||.|
  Fly   568 VQGKADPINSAFHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQV--EQKTLELNK 630

Human   792 RLGALEEPDMTGQLVDLPEYYSWGEELTETQHMIQRRIMESVNGLKSLSAGRVVVVKNQEHHNAL 856
             |...:|.       ::..|:....:|.:.....::.|.:....|..|..||:|.|.........
  Fly   631 -LTIKDEH-------NIASYHHIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDW 687

Human   857 GVILQVSSNSTSRVFTTLVLCDKPLSQDPQDRGPATAEVPYPDDLVGFKLFLPEG--------PC 913
            |::|...                  .||...:.|..||   |...:...|.:.|.        ||
  Fly   688 GIVLNFK------------------KQDQSRKNPLKAE---PSVTIDVLLHVSEAAAKTGDTEPC 731

Human   914 ---DHTVVKLQPGDMAAIT-TKVLRVNGEKILEDFSKRQQPKFKKDPPLAAVTTAVQELLRLAQA 974
               :...:::.|.....|| ...:||.....|.....|:           ||...:||   ..:.
  Fly   732 KPNERGCMEVVPVAHTLITQISSIRVYFPNDLRSADNRR-----------AVLKTIQE---AKKR 782

Human   975 HPAGPPTLDPVNDLQLKDMSVVEGGLRARKLEELIQGAQCVHSPRFPAQYLKLRERMQIQKEMER 1039
            .|.|||.|:|::|:.:||....:......:.|:.::......||.....:.:.::::.:||:::.
  Fly   783 FPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHRRYQDKVTLQKQLQD 847

Human  1040 LRF-LLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSS-HELLLTELMFDNALST 1102
            |:. |.:.:|||.:.|...|..|||.:||......::..|||||.:|| .|||:||::|:...:.
  Fly   848 LKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADELLMTEMIFNGVFND 912

Human  1103 LRPEEIAALLSGLVCQSPGDAGDQLPNTLKQGIERVRAVAKRIGEVQVACGLNQTVEEFVGELNF 1167
            |...:..||||..||........:....|...:..::.:|:||.:|...|.|:...:.:|.:...
  Fly   913 LTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTECKLDLDADTYVDKFKP 977

Human  1168 GLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATL 1232
            .|::||..|.:|..|..:..::...||.::||::||.|:.|.:..|::.:|...|..|......|
  Fly   978 FLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIGNTDLENKFSEGIRL 1042

Human  1233 LRRDIVFAASLY 1244
            |:||||||||||
  Fly  1043 LKRDIVFAASLY 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SKIC2	NP_008860.4	Ski2_N	79..201	CDD:465562
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..246		4/20 (20%)
		Dob10	309..1238	CDD:443638	348/957 (36%)
		DEVH box. /evidence=ECO:0000305|PubMed:35120588	423..426		2/2 (100%)
Mtr4	NP_524929.1	Dob10	145..1048	CDD:443638	349/962 (36%)