Protein Alignment SIX3 and Six4

DIOPT Version :10

• Sequence 1: NP_005404.1
• Gene: SIX3 / 6496
• HGNCID: 10889
• Length: 332
• Species: Homo sapiens
• Sequence 2: NP_649256.1
• Gene: Six4 / 40297
• FlyBaseID: FBgn0027364
• Length: 392
• Species: Drosophila melanogaster
• Alignment Length: 277
• Identity: 128/277 - (46%)
• Similarity: 170/277 - (61%)
• Gaps: 28/277 - (10%)

Human    43 GAGGGSGGGNG-------AG----GGGAGGAGGGGG---GGSRAPPEELSMFQLP----TLNFSP 89
            |:.|..|..||       ||    |||.||..|.||   ....|.....::...|    .|.||.
  Fly   119 GSSGNLGDLNGNTKTDLCAGLQRSGGGLGGNAGSGGHLISNLTAAHNMSAVSSFPIDAKMLQFST 183

Human    90 EQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILEN 154
            :|:..:||.|::.||||:|..||.|||.:    |....:||:|||||:||::.|.|.:||::||.
  Fly   184 DQIQCMCEALQQKGDIEKLTTFLCSLPPS----EFFKTNESVLRARAMVAYNLGQFHELYNLLET 244

Human   155 HKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRS 219
            |.|:.:.|..||.:|.:|||:||||:||||||.|||||:|||:|||:||||||:..:||||::|:
  Fly   245 HCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKEKSRN 309

Human   220 LLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLA 284
            .|::.||.:.||.|.:|:.||:.||||.|||.|||||||||||  ..:.|....::.|.|  .|.
  Fly   310 ALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDR--TPQQRPDIMSVLPVG--QLD 370

Human   285 EPGCPTHGSAES--PST 299
            ..|.|...:|.|  |.|
  Fly   371 GNGFPRMFNAPSYYPET 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIX3	NP_005404.1	Interaction with TLE5. /evidence=ECO:0000250|UniProtKB:Q62233	72..119		19/50 (38%)
		SIX1_SD	87..200	CDD:465293	60/112 (54%)
		homeodomain	208..256	CDD:238039	24/47 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	232..251		10/18 (56%)
		Bind to RHO promoter. /evidence=ECO:0000250|UniProtKB:Q62233	232..234		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..332		15/44 (34%)
Six4	NP_649256.1	SIX1_SD	181..290	CDD:465293	60/112 (54%)
		homeodomain	301..355	CDD:238039	32/55 (58%)