Protein Alignment SIX1 and Six4

DIOPT Version :9

• Sequence 1: NP_005973.1
• Gene: SIX1 / 6495
• HGNCID: 10887
• Length: 284
• Species: Homo sapiens
• Sequence 2: NP_649256.1
• Gene: Six4 / 40297
• FlyBaseID: FBgn0027364
• Length: 392
• Species: Drosophila melanogaster
• Alignment Length: 255
• Identity: 126/255 - (49%)
• Similarity: 153/255 - (60%)
• Gaps: 51/255 - (20%)

Human     1 MSMLPSF-------GFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAF 58
            ||.:.||       .|:.:|:.|:||.|||.|::|:|..||.|||..:....|||||:|:|:||:
  Fly   166 MSAVSSFPIDAKMLQFSTDQIQCMCEALQQKGDIEKLTTFLCSLPPSEFFKTNESVLRARAMVAY 230

Human    59 HRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWD 123
            :.|.|.|||.:||:|.||...|..||.||.||||.||||:||||||||.|||:|:|:|||:||||
  Fly   231 NLGQFHELYNLLETHCFSIKYHVDLQNLWFKAHYKEAEKVRGRPLGAVDKYRLRKKYPLPKTIWD 295

Human   124 GEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERE 188
            ||||.||||||||..|::.|..|.||:|.||:.||:.||||.|||||||||||||||
  Fly   296 GEETVYCFKEKSRNALKDCYLTNRYPTPDEKKTLAKKTGLTLTQVSNWFKNRRQRDR-------- 352

Human   189 NTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVL---LLQGNMGHARSSN 245
                                            :|.|.||..|||   .|.|| |..|..|
  Fly   353 --------------------------------TPQQRPDIMSVLPVGQLDGN-GFPRMFN 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIX1	NP_005973.1	SIX1_SD	9..118	CDD:374862	62/108 (57%)
		homeodomain	129..180	CDD:238039	35/50 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..269		26/81 (32%)
Six4	NP_649256.1	SIX1_SD	181..290	CDD:293483	62/108 (57%)
		homeodomain	301..355	CDD:238039	37/93 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001063
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910