DRSC/TRiP Functional Genomics Resources

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Protein Alignment SLC30A5 and ZnT86D

DIOPT Version :10

Sequence 1:NP_075053.2 Gene:SLC30A5 / 64924 HGNCID:19089 Length:765 Species:Homo sapiens
Sequence 2:NP_650049.1 Gene:ZnT86D / 41342 FlyBaseID:FBgn0037875 Length:366 Species:Drosophila melanogaster


Alignment Length:349 Identity:167/349 - (47%)
Similarity:227/349 - (65%) Gaps:24/349 - (6%)


- Green bases have known domain annotations that are detailed below.


Human   403 IKESL----KQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGL 463
            |:|.|    :.|..:.:||.:|.||.|||.|.|||||||::|||||||||.|||.|||:.|:.||
  Fly    16 IREKLNSWKRLIFSDRNSRNLFLFLLLNLSFAFVELFYGIVTNSLGLISDSFHMFFDCTGLLAGL 80

Human   464 FAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVG 528
            .|:::::|||...|||||.|.|:|:||:|.|||:.||||:..|.|.|||:|||:....|..|||.
  Fly    81 AASVITKWKANDKFSYGYVRAEVLAGFVNSLFLLFIAFFILSEGVERLIEPPEVKHERLFVVSVL 145

Human   529 GLIVNLIGICAFS---HAHSH-AHGASQGSCHSSDHSHSH-------HM-------HGHS-DH-G 573
            ||:|||:||.||:   |.||| .||.|.|..|...|||.|       |.       |||| || .
  Fly   146 GLLVNLVGIYAFNHGGHGHSHGGHGHSHGGGHGHGHSHGHTDAGNHNHQAITLDNGHGHSHDHDS 210

Human   574 HGHSHGSAGGGMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVV 638
            ||||||...|..:..|||||||:|||||||:|||:|.||:..|||.||||:||:|||:||.|||:
  Fly   211 HGHSHGDMSGSNSQIMRGVFLHILADTLGSVGVIISAVLMHMFGWMIADPICSIFIALLIALSVL 275

Human   639 PLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLE 703
            .|||::..:|:.|.|.:.::.|....:|:..:.|:.:.::||||...:.:..|.:.::|:.:|..
  Fly   276 SLIKESIMILMQRQPADLDRSLPQCYQKVTGLAGVYAVQEPHFWTLCSDVYVGALKLEVSKNVDP 340

Human   704 QRIVQQVTGILKDAGVNNLTIQVE 727
            :.:|.....|.:..||..:.||::
  Fly   341 KYVVTHTRMIFEAVGVKQIYIQLD 364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLC30A5NP_075053.2 CzcD 413..730 CDD:440843 163/335 (49%)
Mediates homodimerization with SLC30A6. /evidence=ECO:0000269|PubMed:19759014 420..640 139/239 (58%)
His-rich loop, required for zinc transport. /evidence=ECO:0000305|PubMed:15994300 542..578 23/52 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..581 20/45 (44%)
ZnT86DNP_650049.1 CzcD 45..365 CDD:440843 155/320 (48%)

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