DRSC/TRiP Functional Genomics Resources

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Protein Alignment SLC30A5 and ZnT35C

DIOPT Version :10

Sequence 1:NP_075053.2 Gene:SLC30A5 / 64924 HGNCID:19089 Length:765 Species:Homo sapiens
Sequence 2:NP_609741.3 Gene:ZnT35C / 34890 FlyBaseID:FBgn0028516 Length:472 Species:Drosophila melanogaster


Alignment Length:409 Identity:100/409 - (24%)
Similarity:170/409 - (41%) Gaps:97/409 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   417 RQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGY 481
            |::.....|.|:|...|:..|||:|||.:.:|..|:|.|.::.::.|||..::...:|:..|:|:
  Fly    89 RKLIIASILCLVFMIAEIVGGVLSNSLAIATDAAHLLTDFASFMISLFAIWIAGRPSTQRMSFGW 153

Human   482 GRIEILSGFINGLFLIVIAFFVFMESVARLIDPP-ELDTHMLTPVSVGGLIVNLIGICAFSHAHS 545
            .|.|::....:...:.||...:...::.|||... |::..::...|...::||:|......|.||
  Fly   154 YRAEVIGAMASVFMIWVITGILVWLAIGRLISGDYEVNAKIMLITSGLAILVNVIMGVQLQHGHS 218

Human   546 H----AHGASQGSCHSSDH----------SHSHHMHGHSDH--------GHG------------- 575
            |    .||.|.|...::.|          |.|..:.|...:        |.|             
  Fly   219 HGLGGGHGHSHGGSKNASHVQATSTPCSDSPSQRIEGGVAYAPEDAELPGGGLPTFSYQNTKLVD 283

Human   576 ------------------HSHGSAGG--GMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFGW-- 618
                              |.||...|  .:|.|:|...:||:.|.:.|:||.|:..:|  :.|  
  Fly   284 PTLDLEIAAVLAETAPGSHHHGGPVGREAVNMNVRAALIHVIGDVIQSVGVFVAAGVI--YFWPE 346

Human   619 -FIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIA--LEKIQKIEGLISYRDPH 680
             .|.||:|:...:|::..:...::|||. ::|:...|.|   :|.|  |:..|.|||:....:..
  Fly   347 YSIVDPICTFVFSIIVLFTTFTIMKDAL-LVLMEGTPNY---MHYAEVLQIFQGIEGVERVHNLR 407

Human   681 FWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVN------NLTIQVEKEAYFQHMSGLS 739
            .|..|.:.||.:.|:.:..:...:||:...|     :.|:      ..|||:|.           
  Fly   408 IWALSINKVALSAHLAIAENANPKRILDAAT-----SAVHLRYNFFETTIQIED----------- 456

Human   740 TGFHDVLAMTKQMESMKYC 758
                    .|.||||...|
  Fly   457 --------YTAQMESCLQC 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SLC30A5NP_075053.2 CzcD 413..730 CDD:440843 94/379 (25%)
Mediates homodimerization with SLC30A6. /evidence=ECO:0000269|PubMed:19759014 420..640 67/278 (24%)
His-rich loop, required for zinc transport. /evidence=ECO:0000305|PubMed:15994300 542..578 15/88 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..581 11/78 (14%)
ZnT35CNP_609741.3 CzcD 73..455 CDD:440843 93/376 (25%)

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