DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RANBP17 and Ranbp16

DIOPT Version :9

Sequence 1:	XP_011532929.1	Gene:	RANBP17 / 64901	HGNCID:	14428	Length:	1092	Species:	Homo sapiens
Sequence 2:	NP_001188596.1	Gene:	Ranbp16 / 118436	FlyBaseID:	FBgn0053180	Length:	1110	Species:	Drosophila melanogaster

Alignment Length:	1098	Identity:	591/1098 - (53%)
Similarity:	784/1098 - (71%)	Gaps:	31/1098 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     8 LAELEVLCTHLYIGTDLTQRIEAEKALLELIDSPECLSKCQLLLEQGTTSYAQLLAATCLSKLVS 72
            :.:|||||..||..||:..|.||||||:..:.|.:.|.||||||::..:||||||||:.|:||:.
  Fly     3 IQQLEVLCKQLYEATDIRIRSEAEKALVTFVSSQDALPKCQLLLQRADSSYAQLLAASTLTKLIQ 67

Human    73 RVSPLPVEQRMDIRNYILNYVASQPKLAPFVIQALIQVIAKITKLGWFEVQKDQFVFREIIADVK 137
            .:|   :::|:|||:|.|||:|:.|.|..||:|||:.::||:||.|||:..|::.||:.::.|||
  Fly    68 GLS---LQERIDIRSYALNYLATVPNLQHFVVQALVSLLAKLTKYGWFDSYKEEMVFQNLLEDVK 129

Human   138 KFLQGTVEHCIIGVIILSELTQEMNLV---DYSRPSAKHRKIATSFRDTSLKDVLVLACSLLKEV 199
            |||||:||||.|||.|||:|..|||.|   |.....:|.|||||||||..|.:..:|:||||...
  Fly   130 KFLQGSVEHCTIGVQILSQLVCEMNSVVEMDVQVSFSKMRKIATSFRDQQLLETFLLSCSLLVSA 194

Human   200 --FAKPLNLQDQCQQNLVMQVLKLVLNCLNFDFIGSSADESADDLCTVQIPTTWRTIFLEPETLD 262
              .:|.::..|:.||.|:..||:|..|||:|||||||.||||||:..|||||.||..||:..||.
  Fly   195 RDNSKNISFMDESQQALISHVLRLTKNCLSFDFIGSSTDESADDMNNVQIPTAWRPAFLDSNTLK 259

Human   263 LFFNLYHSLPPLLSQLALSCLVQFASTRRSLFNSPERAKYLGNLIKGVKRILENPQGLSDPGNYH 327
            |||:||..||..|:..::|||||..|.||||||:.||.|:|.:|::|||.||....|||||.|||
  Fly   260 LFFDLYQILPNGLASYSISCLVQITSVRRSLFNNSERTKFLTHLVEGVKDILTTLHGLSDPDNYH 324

Human   328 EFCRFLARLKTNYQLGELVMVKEYPEVIRLIANFTITSLQHWEFAPNSVHYLLTLWQRMVASVPF 392
            ||||.|||||:|||||||:.|..|||.|:|||.||:.||..|.|||||||||||||||||||||:
  Fly   325 EFCRLLARLKSNYQLGELIAVPCYPEAIQLIAKFTVESLHLWLFAPNSVHYLLTLWQRMVASVPY 389

Human   393 VKSTEPHLLDTYAPEITKAFITSRLDSVAIVVRDHLDDPLDDTATVFQQLEQLCTVSRCEYEKTC 457
            |||.:||||.||.||:.||:|.||||:|.:::||:|||||||...|.||||||..:.||||.|||
  Fly   390 VKSPDPHLLGTYTPEVIKAYIESRLDAVPVIIRDNLDDPLDDFCMVQQQLEQLSVIERCEYNKTC 454

Human   458 ALLVQLFDQNAQNYQKLLHPYSGVTVDITIQEGRLAWLVYLVGTVVGGRLTYTSTDEHDAMDGEL 522
            .||||.|||.|:.|:.||...:..::||||.|.:|.||||::|:.:.||||..::||||.||.||
  Fly   455 NLLVQHFDQKAREYENLLQTPNANSIDITIHELQLTWLVYIIGSAIVGRLTVATSDEHDTMDAEL 519

Human   523 SCRVFQLISLMDTGLPRCCNEKIELAILWFLDQFRKTYVGDQLQRTSKVYARMSEVLGITDDNHV 587
            ..||.||::|.|..||:...||:|||||.||||.||.:..:|.|: :.:..|:|||.|:||:..:
  Fly   520 VIRVLQLMTLTDARLPQAGCEKLELAILSFLDQVRKMHSSEQAQK-ANLNKRLSEVFGLTDEQML 583

Human   588 LETFMTKIVTNLKYWGRYEPVISRTLQFLNDLSVGYILLKKLVKIDAVKFMLKNHTSEHFPFLGI 652
            |.....||:||||:|||.|.:|::||..|::|||.:..::||.:::.|:|||.:||||||||||
  Fly   584 LSFINRKIITNLKFWGRSESIITKTLMLLSELSVHFNSVRKLARLEEVQFMLTHHTSEHFPFLG- 647

Human   653 SDNHSLSDFRCRTTFYTALTRLLMVDLGEDEDEFENFMLPLTVAFETV--LQIFNNNFKQEDVKR 715
             .|.|||:.||||.|||:|.||||.||||||:.|.||:.|||..||::  :.:.||.|..|:.|:
  Fly   648 -TNSSLSEMRCRTMFYTSLGRLLMFDLGEDEERFYNFLEPLTNQFESLGSVMMDNNIFSNEEAKK 711

Human   716 MLIGLARDLRGIAFALNTKTSYTMLFDWMLYKRYPTYLPLLQNAVERWYGEPTCTTPILKLMAEL 780
            ::|||||||||:|..||.:..|||||:| ||  |..|||:|..|::.|..:|..|||||||.|||
  Fly   712 VIIGLARDLRGLALPLNARIQYTMLFEW-LY--YADYLPILLRAMDLWAHDPAVTTPILKLFAEL 773

Human   781 MQNRSQRLNFDVSSPNGILLFREASKMVCTYGNQILSLGSLSKDQIYPMKLKGISICYSALKSAL 845
            :..|:|||..:||||.||||||||||::|.|||:||. ..:.::::|||:||||:||:..||::|
  Fly   774 VHCRTQRLAGNVSSPMGILLFREASKLICIYGNRILH-QEVPRERLYPMRLKGIAICFLILKNSL 837

Human   846 CGNYVSFGVFKLYGDNHFDNVLQAFVKMLLSVSHSDLLQYRKLSQSYYPLLECLTQDHMSFIINL 910
            .||||:.||||||||:..|:||....|::|::...||::|.|||.:||.||.||:|||:|::..|
  Fly   838 GGNYVNCGVFKLYGDDTLDSVLNIIAKLILTIEQRDLIEYPKLSTAYYNLLNCLSQDHVSYLAAL 902

Human   911 EPPVLMYVLTSISEGLTTLDTVVSSSCCTSLDYIVTYLFKHIAKE-----GKKPLRCREATQAGQ 970
            ||...:|:|.|:::||..||:....||||.||.||:|:||.:..:     .||   .|...|...
  Fly   903 EPAAFVYILKSLTKGLAALDSATYISCCTILDSIVSYIFKQLQMKVSTFPNKK---LRSLNQENV 964

Human   971 RLLHFMQQNPDVLQQMMSVLMNTIVFEDCRNQWSVSRPLLGLILLNEKYFSELRASLINSQPLPK 1035
            :.|..::.|.::||.|||.|:|.::.||||||||:|||||.||||.|.|:..|:..:|.:||:.|
  Fly   965 QFLKVVEMNSELLQSMMSSLLNNVLQEDCRNQWSMSRPLLVLILLYEDYYRSLKDRIICAQPIEK 1029

Human  1036 QEVLAQCFRNLMEGVEQNLSVKNRDRFTQNLSVFRRDVAEALRSDGN------TEPCS 1087
            |:.:||.|.:||.|:|:|:|.||:::||||:|.|||||....:|...      |.|.|
  Fly  1030 QQTMAQWFDDLMVGIERNVSSKNKEKFTQNMSTFRRDVVNLPKSTAGGADYIATNPSS 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RANBP17	XP_011532929.1	IBN_N	30..95	CDD:281761	33/64 (52%)
Ranbp16	NP_001188596.1	IBN_N	25..87	CDD:281761	33/64 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159015
Domainoid	1	1.000	1129	1.000	Domainoid score	I19
eggNOG	1	0.900	-	-		E1_KOG1410
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1240	1.000	Inparanoid score	I183
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53933
OrthoDB	1	1.010	-	-		D198413at2759
OrthoFinder	1	1.000	-	-		FOG0004030
OrthoInspector	1	1.000	-	-		otm41223
orthoMCL	1	0.900	-	-		OOG6_102412
Panther	1	1.100	-	-	O	PTHR12596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2778
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770