DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BMP1 and bmp1a

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_001035126.1	Gene:	bmp1a / 572452	ZFINID:	ZDB-GENE-060818-1	Length:	986	Species:	Danio rerio

Alignment Length:	992	Identity:	768/992 - (77%)
Similarity:	877/992 - (88%)	Gaps:	21/992 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     5 ARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQ 69
            ||..|||....| .....||..:..|.:.....|:.::|||||||.|:||||||||||:|.|.|.
Zfish     5 ARCALLLSSFSL-LAALDLDAIEPGYYVETSSPSDLIDYKDPCKAVAYLGDIALDEEDMRMFTVD 68

Human    70 QAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRRAATSRPERVWPDGV 134
            :.|:|...|       ..:..:|:|   .|.:.:.........||..|.|||||||||||||:||
Zfish    69 RIVNLAERT-------VTILNHTNT---GSLSNETSVNTTASSRGSHRRRRAATSRPERVWPEGV 123

Human   135 IPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAI 199
            ||:||.|||:|||||:||||||||||||||||:|||.|:||||||||||||||||||||||||||
Zfish   124 IPYVISGNFSGSQRAIFRQAMRHWEKHTCVTFIERTTEESYIVFTYRPCGCCSYVGRRGGGPQAI 188

Human   200 SIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETY 264
            |||||||||||||||||||:||||||||||||.||||:|:|||||||||||||||.||:||||.|
Zfish   189 SIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDEHVSIIRDNIQPGQEYNFLKMEPGEVDSLGEVY 253

Human   265 DFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDS 329
            ||||||||||||||||||||||:|:|:||||:||||||||||||||||||||||||.||::||:|
Zfish   254 DFDSIMHYARNTFSRGIFLDTILPRYDVNGVRPPIGQRTRLSKGDIAQARKLYKCPRCGDSLQES 318

Human   330 TGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRG 394
            :||||||.|||||||:|||:|||||||||||||||||:|||||.|||||:||:|||:||||||:|
Zfish   319 SGNFSSPGYPNGYSAYMHCIWRISVTPGEKIILNFTSMDLYRSHLCWYDHVEIRDGYWRKAPLKG 383

Human   395 RFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSK 459
            ||||.|||:||:|||||||:|||||||||||||.|||||||||:||||.|.||||||||||||:|
Zfish   384 RFCGDKLPDPIISTDSRLWIEFRSSSNWVGKGFSAVYEAICGGEVKKDNGQIQSPNYPDDYRPNK 448

Human   460 VCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSR 524
            ||:|:|.|::|:|||||||||||||||:|||||||||||:||||.|:||:|||:|||||||:|::
Zfish   449 VCVWKITVAQGYHVGLTFQSFEIERHDNCAYDYLEVRDGNSESSPLLGRFCGYDKPDDIKSSSNQ 513

Human   525 LWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEA 589
            ||:|||||||:||||||.|||||:||||||:.|.|||||:||||||||:||||||||.|||.|||
Zfish   514 LWMKFVSDGSVNKAGFAANFFKEMDECSRPDNGRCEQRCVNTLGSYKCACDPGYELAADKRSCEA 578

Human   590 ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGND----------VC 644
            |||||:||||||||||||||||||||||||||||||||||:|.||.|||||||          ||
Zfish   579 ACGGFITKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRITLLFDVFETEGNDVSTRFLPLRGVC 643

Human   645 KYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSK 709
            |||||||||||:|||:|||||||:||||.|||||||||:|||||||||||||||.||||||||||
Zfish   644 KYDFVEVRSGLSADSRLHGKFCGAEKPEAITSQYNNMRIEFKSDNTVSKKGFKAQFFSDKDECSK 708

Human   710 DNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECT 774
            :|||||.:||||||||.||||||||||:||||||||||||.|.|.|||||||||||||||||.||
Zfish   709 ENGGCQHECVNTFGSYSCQCRSGFVLHENKHDCKEAGCDHVVNSVSGTITSPNWPDKYPSKKACT 773

Human   775 WAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFL 839
            ||:|:|||||:|:.|.|:|:|...||||||:|::||||:||..|||:||:|||:|:::||::||:
Zfish   774 WALSTTPGHRIKIAFNEIDMEPHLECAYDHIEIYDGRDSKAQSLGRYCGTKKPQPIISTGNKMFI 838

Human   840 RFYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVEL 904
            ||:||||||:|||:|||..||||:::|:|||||||||||||||||||..||:|||.||:||||||
Zfish   839 RFFSDNSVQKKGFEASHTAECGGRLKAEVKTKDLYSHAQFGDNNYPGASDCQWVITAEKGYGVEL 903

Human   905 VFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGF 969
            :|||||:|||.||||||||||||.|:.:||||||||||||||:||||||:::||||||||.||||
Zfish   904 IFQTFEIEEEADCGYDYMELFDGADTKSPRLGRYCGSGPPEEIYSAGDSIVIKFHSDDTINKKGF 968

Human   970 HLRYTSTKFQDTLHSRK 986
            |:|||||||||||||||
Zfish   969 HVRYTSTKFQDTLHSRK 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	179/198 (90%)
		Astacin	128..321	CDD:279708	173/192 (90%)
		CUB	322..431	CDD:278839	90/108 (83%)
		CUB	435..544	CDD:278839	86/108 (80%)
		FXa_inhibition	555..587	CDD:291342	25/31 (81%)
		CUB	591..700	CDD:278839	99/118 (84%)
		FXa_inhibition	707..742	CDD:291342	29/34 (85%)
		CUB	747..856	CDD:278839	75/108 (69%)
		CUB	860..973	CDD:278839	90/112 (80%)
bmp1a	NP_001035126.1	ZnMc_BMP1_TLD	112..309	CDD:239808	177/196 (90%)
		Astacin	117..309	CDD:279708	172/191 (90%)
		CUB	311..420	CDD:278839	90/108 (83%)
		CUB	424..533	CDD:278839	86/108 (80%)
		FXa_inhibition	544..576	CDD:291342	25/31 (81%)
		CUB	580..699	CDD:278839	99/118 (84%)
		FXa_inhibition	706..741	CDD:291342	29/34 (85%)
		CUB	746..855	CDD:278839	75/108 (69%)
		CUB	859..972	CDD:278839	90/112 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194335724
Domainoid	1	1.000	386	1.000	Domainoid score	I4973
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55955
Inparanoid	1	1.050	1682	1.000	Inparanoid score	I697
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48714
OrthoDB	1	1.010	-	-		D170905at2759
OrthoFinder	1	1.000	-	-		FOG0001707
OrthoInspector	1	1.000	-	-		oto43255
orthoMCL	1	0.900	-	-		OOG6_101061
Panther	1	1.100	-	-	LDO	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2663
SonicParanoid	1	1.000	-	-		X1101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300