DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMP1 and CG11836

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_001356925.1	Gene:	CG11836 / 43007	FlyBaseID:	FBgn0039272	Length:	333	Species:	Drosophila melanogaster

Alignment Length:	280	Identity:	52/280 - (18%)
Similarity:	84/280 - (30%)	Gaps:	79/280 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   493 LEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLW--LKFVSDGSINKAGFAVNFFKEVDECSRPN 555
            ||...|.:||..:...:.|:.     |.||..|:  :..:|.|..|..|.: :...||:.....:
  Fly    22 LEYSKGFNESDAINTIHTGHN-----KRTSKFLFDTIFRISSGVSNAFGLS-DTEDEVEYTENSS 80

Human   556 RGGCEQRC----------------LNTL---------GSYKCSCDPGYELAPDKRRCEAACGGFL 595
            ...|:..|                :|..         |.:.|.   |..|..|.....|.|...|
  Fly    81 LKNCDCDCGFSNEEIRIVGGKPTGVNQYPWMARIVYDGKFHCG---GSLLTKDYVLSAAHCVKKL 142

Human   596 TKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK 660
            .|....:......:|.......|.:.|.......|...|   |..||:.   .:.:|..::. ||
  Fly   143 RKSKIRVIFGDHDQEITSESQAIQRAVTAVIKHKSFDPD---TYNNDIA---LLRLRKPISF-SK 200

Human   661 LHGKFC-----------------------GSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
            :....|                       |.|.|.::    |.::|...|......:.:|:...:
  Fly   201 IIKPICLPRYNYDPAGRIGTVVGWGRTSEGGELPSIV----NQVKVPIMSITECRNQRYKSTRIT 261

Human   703 DK---------DECSKDNGG 713
            ..         |.|..|:||
  Fly   262 SSMLCAGRPSMDSCQGDSGG 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808
		Astacin	128..321	CDD:279708
		CUB	322..431	CDD:278839
		CUB	435..544	CDD:278839	14/52 (27%)
		FXa_inhibition	555..587	CDD:291342	8/56 (14%)
		CUB	591..700	CDD:278839	22/131 (17%)
		FXa_inhibition	707..742	CDD:291342	4/7 (57%)
		CUB	747..856	CDD:278839
		CUB	860..973	CDD:278839
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	34/199 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910