DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMP1 and CG6763

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_001262871.1	Gene:	CG6763 / 42754	FlyBaseID:	FBgn0039069	Length:	354	Species:	Drosophila melanogaster

Alignment Length:	313	Identity:	86/313 - (27%)
Similarity:	128/313 - (40%)	Gaps:	71/313 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    11 LGLLLLPRPGRPLD---LADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAV 72
            ||..|..:|...|.   :.:::.|..|.:..|..:|.:        ||:.:.:.||
  Fly    57 LGTALFGKPDEELTANRVGNFSADADEMNPEELGSYLE--------GDMLVPQTDL--------- 104

Human    73 DLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRRAATSRPERVWPDGVIPF 137
                                     ...||.|.:                :||    ||:||:|:
  Fly   105 -------------------------IMKNGLPTQ----------------SSR----WPNGVVPY 124

Human   138 VIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIG 202
            .|.|||.....|....|:..:.:.||:.|::|:.|..||.......||.|.|||.||..:.....
  Fly   125 EIRGNFNARDMATIENAIGEYHRRTCIRFVKRSSERDYISIRGDNSGCWSSVGRVGGKQEVNLQS 189

Human   203 KNC-DKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDF 266
            ..| .:.|..:|||.|.:||.||..|.:||.:|:|...|:|.....||.|  ....|:.|..||:
  Fly   190 PGCLSRPGTAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEK--AARTEAFGVPYDY 252

Human   267 DSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKC 319
            .|:|||::|.||  |.....:...:.||. ..:|||...|..||.:..::|.|
  Fly   253 GSVMHYSKNAFS--INGQPTILAMQANGA-DKMGQRNGFSDYDIQKLNRMYDC 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	70/200 (35%)
		Astacin	128..321	CDD:279708	68/193 (35%)
		CUB	322..431	CDD:278839
		CUB	435..544	CDD:278839
		FXa_inhibition	555..587	CDD:291342
		CUB	591..700	CDD:278839
		FXa_inhibition	707..742	CDD:291342
		CUB	747..856	CDD:278839
		CUB	860..973	CDD:278839
CG6763	NP_001262871.1	Astacin	116..304	CDD:279708	69/196 (35%)
CG6763	NP_001262871.1	ZnMc_astacin_like	119..300	CDD:239807	64/185 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810