DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMP1 and Sb

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	293	Identity:	63/293 - (21%)
Similarity:	88/293 - (30%)	Gaps:	118/293 - (40%)

- Green bases have known domain annotations that are detailed below.

Human   752 TSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAP 816
            :|:||.:||...|              :.|.||.            |..|...:|..:..|:..|
  Fly   476 SSSSGIVTSSQRP--------------TQPTHRT------------PVLATSGIETNEISDSSIP 514

Human   817 VLGRF------------CG---SKKPEPVLATG-SRMFLRFYSDNSVQRK---GFQASHATECGG 862
            ..|..            ||   ..:||..:..| |..|.|:....||:|.   ||.::|  .|||
  Fly   515 DAGALGHVKTISAARSECGVPTLARPETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTH--RCGG 577

Human   863 ---------------------QVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELV- 905
                                 |:|..|...| :||.|            |.:...|.|...::|
  Fly   578 ALINENWIATAGHCVDDLLISQIRIRVGEYD-FSHVQ------------EQLPYIERGVAKKVVH 629

Human   906 ----FQTFEVE---------------------EETDCGYDYMELFDGYDSTAPRLGRYCGSGPPE 945
                |.|:|.:                     .|||      .|..|.::|....||....|...
  Fly   630 PKYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETD------SLLIGMNATVTGWGRLSEGGTLP 688

Human   946 EVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKF 978
            .|.   ..|.|...|:|..  |...:|....:|
  Fly   689 SVL---QEVSVPIVSNDNC--KSMFMRAGRQEF 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808
		Astacin	128..321	CDD:279708
		CUB	322..431	CDD:278839
		CUB	435..544	CDD:278839
		FXa_inhibition	555..587	CDD:291342
		CUB	591..700	CDD:278839
		FXa_inhibition	707..742	CDD:291342
		CUB	747..856	CDD:278839	28/122 (23%)
		CUB	860..973	CDD:278839	32/159 (20%)
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	44/200 (22%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	44/199 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910