DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMP1 and CG6974

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_650414.1	Gene:	CG6974 / 41815	FlyBaseID:	FBgn0038285	Length:	251	Species:	Drosophila melanogaster

Alignment Length:	214	Identity:	64/214 - (29%)
Similarity:	106/214 - (49%)	Gaps:	10/214 - (4%)

- Green bases have known domain annotations that are detailed below.

Human   113 RGRSRSRRAATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDE----D 173
            :..:::|.|.|| |.:.||...|.:.|..:::..:.|..|.||..:.:.|||.|.|....    .
  Fly    41 QAEAKTRNALTS-PLQRWPGNKILYRISTDYSEQEVANVRTAMSSFGEQTCVQFEEIEGAPPAGK 104

Human   174 SYIVFTYRPCGCCSYVGRR--GGGPQAISIGKNCDKF-GIVVHELGHVVGFWHEHTRPDRDRHVS 235
            .|:.|...|..|.:.||.:  ..||..:.:.:.|... .::.||..|::|.:||.:|||||.:|.
  Fly   105 RYVSFKKSPNMCGTRVGYQPLSFGPHEVVLNEKCLTMPAVIQHETLHLLGLFHEQSRPDRDEYVQ 169

Human   236 IVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG 300
            |..:||.......|:.|:  :..:....||::|:|||::|.|::.....||........|:..:|
  Fly   170 IDYDNIPRKYWSQFMAMD--QTTTFNVPYDYESVMHYSKNAFAKDPSKPTIRALIGGKAVEREMG 232

Human   301 QRTRLSKGDIAQARKLYKC 319
            |....|:||..:.|.:|||
  Fly   233 QVRGPSEGDWTKIRLMYKC 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	63/206 (31%)
		Astacin	128..321	CDD:279708	59/199 (30%)
		CUB	322..431	CDD:278839
		CUB	435..544	CDD:278839
		FXa_inhibition	555..587	CDD:291342
		CUB	591..700	CDD:278839
		FXa_inhibition	707..742	CDD:291342
		CUB	747..856	CDD:278839
		CUB	860..973	CDD:278839
CG6974	NP_650414.1	Astacin	55..251	CDD:279708	57/197 (29%)
CG6974	NP_650414.1	ZnMc_astacin_like	59..249	CDD:239807	54/191 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810