DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMP1 and CG10280

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_001246942.1	Gene:	CG10280 / 40740	FlyBaseID:	FBgn0037395	Length:	362	Species:	Drosophila melanogaster

Alignment Length:	322	Identity:	91/322 - (28%)
Similarity:	131/322 - (40%)	Gaps:	91/322 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    21 RPL--DLADYTYDLAEEDDSEPLNYKDP-CKAAAFLGDIALDEEDLRAFQVQQAVDLRRHTARKS 82
            :||  :...|..|:.::|    |...|| .....|.||||:|  ......::..|:..||
  Fly    91 KPLSDEYDPYGPDIGDDD----LGIDDPETMPRLFQGDIAID--PYTYITLRLGVNPMRH----- 144

Human    83 SIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRRAATSRPERVWPDGVIPFVIGGNFTGSQ 147
                                                       |:|:||:|.|||.|...:...:
  Fly   145 -------------------------------------------PKRLWPNGTIPFEISPRYANQE 166

Human   148 RAVFRQAMRHWEKHTCVTFLERTDE-DSYIVF---TYRPCGCCSYVGRRGGGPQAISIGK----- 203
            |....||::.:...|||.|:....| |.|::.   ...|.||.|||||| ||.|.:|:.:
  Fly   167 RQAIIQAVKTFNSLTCVHFVPYDGEVDDYLLIEPPLEGPQGCWSYVGRR-GGEQVVSLQRPDENS 230

Human   204 -NC-DKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDF 266
             :| ...|.::|||.|.:|.:||.:|.|||..|.|..:||.|....|| |:..::.......||:
  Fly   231 AHCFSSEGRIMHELMHAIGIYHEQSRADRDNFVKIHWDNIVPRFRKNF-KLVSKKKGKYAFDYDY 294

Human   267 DSIMHYARNTFSRGIFLDTIVPKYEVNGVKPP---------IGQRTRLSKGDIAQARKLYKC 319
            :|:|||....||:.            .|.||.         ||||..:||.|..:..:||.|
  Fly   295 NSVMHYGEFYFSKR------------KGEKPTMTPLQPGVRIGQRKTISKIDCLKINELYGC 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	74/219 (34%)
		Astacin	128..321	CDD:279708	73/212 (34%)
		CUB	322..431	CDD:278839
		CUB	435..544	CDD:278839
		FXa_inhibition	555..587	CDD:291342
		CUB	591..700	CDD:278839
		FXa_inhibition	707..742	CDD:291342
		CUB	747..856	CDD:278839
		CUB	860..973	CDD:278839
CG10280	NP_001246942.1	Astacin	147..344	CDD:279708	72/210 (34%)
CG10280	NP_001246942.1	ZnMc_astacin_like	151..342	CDD:239807	67/204 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810