DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMP1 and CG32432

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster

Alignment Length:	1024	Identity:	197/1024 - (19%)
Similarity:	309/1024 - (30%)	Gaps:	381/1024 - (37%)

- Green bases have known domain annotations that are detailed below.

Human   131 PDGVIPFV------IGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYV 189
            |||.:...      |||.:.||.          |..   |.|...|..   ::||.|    .:.:
  Fly   316 PDGYMQIAESARTPIGGMWCGSS----------WGP---VLFYSETRS---LIFTIR----LNRL 360

Human   190 GRRGGG--------PQAISIGKNCDKF-GIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQ 245
            .|...|        .:.:|...:..:: ||.:.||..    ||..:        |.:.:..|..|
  Fly   361 ARDQSGYNFDFRIRYKVLSRDSSVTRYGGIKLAELAQ----WHNRS--------SFLNQQQQQQQ 413

Human   246 EYNFLKMEPQEVESLGETY-------------DFDSIMHYARN-TFSRGIFLDTIVPKYEVNGVK 296
            :....:.:.|....:.|.:             ||.....||.| ||...  |:..:.|.|.|..:
  Fly   414 QQQQQQQQQQGAPGILEDFTNSSVARSDRYGQDFSLFSAYANNKTFMAS--LEKSLAKDEQNYTE 476

Human   297 PPIGQRTRLSKGDIAQARKLYKCPACGETLQD---STGNFSSPEYPNGYSAHMHCVWRI---SVT 355
            |      :...||:...      ..|.....|   ......||.:|..|..::.|.:.:   .|.
  Fly   477 P------KYYLGDLIPG------TYCSRIFSDCDKKPCRLQSPNFPGIYPRNLTCYYAVRQHDVP 529

Human   356 PGEKIIL-------NFTSLDL---------------------YRSRL-----CWY---------- 377
            .|:..::       |...:..                     :..||     |.|
  Fly   530 HGKHALILVKQPKGNLVWISTQETAAANKMAPPPSASDKDKKFEPRLKTWNYCDYIQENVKPKWK 594

Human   378 --DYVEVRDGFWRKAPLRGRFCGSKLPEP-IVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG-- 437
              |||.|.||:..:.|:..:|||.....| .||:...|.|||.:|......|..:....:.|.
  Fly   595 STDYVTVYDGYTTRDPIILKFCGGGQAVPAAVSSGPELLVEFSTSPFGTFTGTSSQVLPLYGFQL 659

Human   438 DVKKDYGHIQSPNYPDDYR----------------------PSKVCIWRIQVSEGFHVGLTFQSF 480
            :|:..:..||||.|..:.:                      |:..|::.:|   |..|..||...
  Fly   660 EVEVQFVDIQSPTYSKNKKPCEFWIRGAGRGILESPKHSLAPNSTCLYHLQ---GLGVFKTFDHL 721

Human   481 EIERHDS---------------------------------------------------------- 487
            .:.|..|
  Fly   722 SLSRRTSSQSGMHQPLSRFKVWISVLKFNLDPEFGQIDETSVGAIGVLQTQEDCSGMLRIWDGTL 786

Human   488 ----------CA-----YDYLEVRDGH--SESSTLIGRYC---------------GYEKPDDIK- 519
                      ||     |:.|    ||  ..|:::|.|:|               .|.:|..|.
  Fly   787 RDAPVCKDLNCATETSSYNTL----GHYTHNSTSVIARFCRGTIPRTCDRSNINETYARPCTISE 847

Human   520 ---STSSRLWLKFVSDGS--INKAGFAVNF-FKEVDECSRPNRGG---CEQRCLNTLGSYKCSCD 575
               |||..:.|:..:..|  :....|.:.: |.::.:...|..||   |.::.|:::...|   |
  Fly   848 SYVSTSDAITLELRNTESTVLRPLDFKLKYEFIDLHQDGLPWGGGEHDCNRKFLSSMMDRK---D 909

Human   576 PGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEG 640
            |..               |.:..|..:...|..:    |..||::..|....|:.::.....|.
  Fly   910 PAI---------------FRSVRNIFLFGRGGTR----NLKCIYKFEAQRGERVRIKMRKVTTT- 954

Human   641 NDVCKYDFVEV---RSGLTADSK---------------LH-GKFCGSEK----PEVITSQYNNMR 682
            |..| |..|:.   ||....|:.               || |..|.|..    |...||...::.
  Fly   955 NRPC-YSRVDEDINRSFCYGDTNVRIEIFERPYHDSILLHRGCMCNSSNQSHLPVEYTSTSRDVE 1018

Human   683 VEFKSDN--------TVSKKGFKAHFFSDKDECSKDNG---GCQQDCVNTFGSYECQCRSGFVLH 736
            |.|.:.|        ||:.:|. ..|......| ||..   |.......|||..||:.|...:..
  Fly  1019 VHFIAQNMTTLDDPDTVNFEGM-FEFVKAPTSC-KDGRRKFGPSGTIDMTFGDVECRSRPWLIEP 1081

Human   737 DN---------------KHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVK 786
            .|               ||:..:       |..:..:.:..|..:..|:.    .::::.|
  Fly  1082 SNGNKFLYVRLKAIFLSKHNPTQ-------TLNATYVQTDTWRCETKSRA----VLTTSEG---- 1131

Human   787 LTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRM----FLR----FYS 843
            ||.:...: |....||:.:|:|...           .:::|...|...||.    |||    .||
  Fly  1132 LTIVACPL-SPDSNAYEFVEIFSSG-----------WNERPNFALVNRSRAISVEFLRPGNGEYS 1184

Human   844 DN---SVQRKGFQASHATEC-------GGQVRADVKTKDLYSHAQFGDN 882
            .|   .:.|.  ..|.|.:|       |..|.|.|.. |...|...||:
  Fly  1185 FNWMELIPRP--TLSMAEDCQFKCAELGACVNASVWC-DGVVHCPSGDD 1230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	43/217 (20%)
		Astacin	128..321	CDD:279708	43/218 (20%)
		CUB	322..431	CDD:278839	33/160 (21%)
		CUB	435..544	CDD:278839	35/228 (15%)
		FXa_inhibition	555..587	CDD:291342	7/34 (21%)
		CUB	591..700	CDD:278839	30/139 (22%)
		FXa_inhibition	707..742	CDD:291342	13/52 (25%)
		CUB	747..856	CDD:278839	22/119 (18%)
		CUB	860..973	CDD:278839	9/30 (30%)
CG32432	NP_649266.1	LDLa	214..245	CDD:197566
		CUB	503..646	CDD:238001	30/142 (21%)
		LDLa	1203..1231	CDD:197566	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910