DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMP1 and CG42255

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_729748.3	Gene:	CG42255 / 39334	FlyBaseID:	FBgn0259140	Length:	3613	Species:	Drosophila melanogaster

Alignment Length:	999	Identity:	223/999 - (22%)
Similarity:	364/999 - (36%)	Gaps:	279/999 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    12 GLLLLPR-PGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLR 75
            |::..|. ||...|....||:|     :.||:.....:........|.:|.|.....|..:.|.:
  Fly   866 GIISTPNYPGPYFDDMTCTYNL-----TGPLDTAVRMRITDLSLGTANNENDTSYLDVYLSADQK 925

Human    76 RHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRRAATSRPERVWPDGVIPFVIG 140
            ||..:.:.....:                           |.|.||:              .|..
  Fly   926 RHIVKSTDNLILL---------------------------SHSNRAS--------------LVFH 949

Human   141 GNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNC 205
            |:..|       :.||                   :.:.:.|..|..::...|........|..|
  Fly   950 GSGGG-------RGMR-------------------LEYNFVPNQCGGFLNEPGRRYVTAVRGTFC 988

Human   206 DKF-------GIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGET 263
            ..|       .|.:|.||....             :||...:..||:..|...      .|:|:.
  Fly   989 QWFIDFPGRKKISIHTLGPTPS-------------ISIYDNSTSPGKLVNSYS------GSVGDV 1034

Human   264 YDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQD 328
            :|.|.:.          |.|.|..|:.|:..::..|.|:                 .:||.|...
  Fly  1035 FDGDLLT----------INLHTNWPRLEIYSIQFDIVQQ-----------------DSCGGTFTA 1072

Human   329 STGNFSSPEYPNGYSAHMHCVWRISVTPGEKIIL---NFTSLDLYRSRLCWYDYVEVRDGFWRKA 390
            ..|...||.:|..|.....|.|.:....|.:|.|   |||..:.|.|..||.|::|:|:|....:
  Fly  1073 RFGYIKSPNWPKNYGESQMCEWILRAPFGHRIELVVHNFTLEEEYSSTGCWTDWLEIRNGDSESS 1137

Human   391 PLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYE---AICGGDVKKDYGHIQSPNYP 452
            ||.||:||:::|..|.|..:.|.::|:|..:...|||...::   |.|||.:....|.|.||:..
  Fly  1138 PLIGRYCGNEIPSRIPSFGNVLHLKFKSDDSMEEKGFLLSWQQMGAGCGGKLSSSMGTIHSPHLL 1202

Human   453 DDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDS--CAYDYLEVRDGHSESSTLIGRYCGYEKP 515
            ...|....|.|:|.|:||..|.|..:|     :|:  |: ..|.:.||.:.:|..|...|.....
  Fly  1203 AGNRGILACDWQIIVAEGSRVSLQLRS-----NDNRICS-GQLTLYDGPTTASNPIVIRCNGTIA 1261

Human   516 DDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYEL 580
            ..::||.:|:.:::                                             |.|::
  Fly  1262 KPLQSTGNRVLVRY---------------------------------------------DVGHD- 1280

Human   581 APD--------KRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVA-PTQYRISLQFDFF 636
            |||        :..|.....|    |.|:|.:|.:|:.|||.::|.|.:.| ..:..:.|.|...
  Fly  1281 APDGTDFMLNYQTNCRVRLEG----LQGAIETPNFPENYPPGQDCEWDIRAGGRKNHLQLIFSHL 1341

Human   637 ETEG-NDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHF 700
            ..|. :.:|..|:|.:...|...:......|.::..|.||:..|.:.:.||||::|..:||:|.:
  Fly  1342 SVEKFSSICLNDYVSLVDMLDDQTLSEQHLCTNDGLEPITTVGNRLLLRFKSDSSVELQGFRAEY 1406

Human   701 FSDKDECSKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPD 765
                                                      |..||...:..:.|...|||.|
  Fly  1407 ------------------------------------------KRIGCGEHLRESGGRFESPNAP- 1428

Human   766 KYPSKKECTWAISSTPGHRVKLTFMEMDIES-QPECAYDHLEVFDGRDAK------AP------- 816
             :....:|.|.|:::.|::::|...|:..|: |.||          |||:      ||
  Fly  1429 -FSVDMDCVWIITASEGNQIRLLLHEVYFEAPQIEC----------RDAESSLSVSAPSGYNSSV 1482

Human   817 VLGRFCGSK-KPEPVLATGSRMFLRFYSDNSVQRKGFQASHA---TECGGQVRAD---VKTKDLY 874
            ||.|.|..: :.:...:.|:.:.:||.|.::..||.|:||..   ..|||.:.|.   :.|...:
  Fly  1483 VLFRSCHEETQTQTFTSPGNELVIRFVSSSAPSRKYFKASFVQVPASCGGYISASSGVLTTPGFH 1547

Human   875 SHAQFGDN--NYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFD-GYDSTAPRLG 936
            :| |...|  ||...::|.|.:....|||:...|:.|.:.:..:|...::||.. ..|:....|.
  Fly  1548 NH-QDSKNVANYTSNIECVWTVEVTNGYGIRPHFEQFNLTDSGNCSVSFVELTKLEPDNKEIFLE 1611

Human   937 RYCGSGPPEEVYSAGDSVLVKFHS 960
            :.||...|......|..:.|:|.|
  Fly  1612 KTCGEDSPMIRIVHGRKLRVRFKS 1635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	32/205 (16%)
		Astacin	128..321	CDD:279708	31/199 (16%)
		CUB	322..431	CDD:278839	39/111 (35%)
		CUB	435..544	CDD:278839	28/110 (25%)
		FXa_inhibition	555..587	CDD:291342	5/39 (13%)
		CUB	591..700	CDD:278839	32/110 (29%)
		FXa_inhibition	707..742	CDD:291342	0/34 (0%)
		CUB	747..856	CDD:278839	33/123 (27%)
		CUB	860..973	CDD:278839	29/107 (27%)
CG42255	NP_729748.3	EGF_CA	156..190	CDD:238011
		EGF_CA	192..233	CDD:238011
		EGF_CA	290..328	CDD:214542
		EGF_CA	330..374	CDD:214542
		EGF	427..455	CDD:278437
		EGF_CA	462..496	CDD:238011
		CUB	503..619	CDD:238001
		CUB	624..738	CDD:238001
		CUB	745..854	CDD:238001
		CUB	857..963	CDD:238001	26/168 (15%)
		CUB	1066..1179	CDD:238001	39/112 (35%)
		CUB	1185..1293	CDD:238001	33/159 (21%)
		CUB	1303..1406	CDD:238001	30/102 (29%)
		CUB	1411..1523	CDD:238001	33/123 (27%)
		CUB	1530..1648	CDD:238001	29/107 (27%)
		CUB	1754..1862	CDD:238001
		CUB	1979..2091	CDD:238001
		CUB	2096..2193	CDD:294042
		CUB	2210..2321	CDD:238001
		CUB	2327..2441	CDD:238001
		CUB	2688..2782	CDD:294042
		CUB	2810..2911	CDD:238001
		CUB	3029..3143	CDD:238001
		CUB	3169..3249	CDD:294042
		CUB	3499..3607	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810