DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BMP1 and tpr

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_611611.1	Gene:	tpr / 37486	FlyBaseID:	FBgn0034661	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	301	Identity:	68/301 - (22%)
Similarity:	83/301 - (27%)	Gaps:	123/301 - (40%)

- Green bases have known domain annotations that are detailed below.

Human   553 RPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNC 617
            ||.....|...|.||.|.....|     |..............|......|:|..|...|| :||
  Fly    55 RPGSSDSENATLATLSSSSMMPD-----AASTTSTTTPAPSSSTTTTRRATTPAPPTLNPP-RNC 113

Human   618 IWQL--VAPTQYRI---------------------------SLQFDFFETEGNDVCKYDF----V 649
            ...:  :|..|.||                           ||..|.|....:. |.|.|    :
  Fly   114 SDCVCGIANIQKRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQFLLTASH-CVYGFRKERI 177

Human   650 EVRSGLTADSKL-HGKFCGSEKPEVITSQYNNMR--------------VE--------------- 684
            .||. |..|.|: |.:....:..||||....|.|              ||
  Fly   178 SVRL-LEHDRKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPGR 241

Human   685 -FKSDNTV------SKKGFKAHFFSD-----------KDECSK--------DN---GGCQQDCVN 720
             ||.:|.:      .|.|...   ||           :|||.|        ||   ||..:.
  Fly   242 SFKGENGIVTGWGALKVGGPT---SDTLQEVQVPILSQDECRKSRYGNKITDNMLCGGYDEG--- 300

Human   721 TFGSYECQCRSGFVLH-----DNKHD----------CKEAG 746
              |...||..||..||     ..:|.          |.:||
  Fly   301 --GKDSCQGDSGGPLHIVASGTREHQIAGVVSWGEGCAKAG 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808
		Astacin	128..321	CDD:279708
		CUB	322..431	CDD:278839
		CUB	435..544	CDD:278839
		FXa_inhibition	555..587	CDD:291342	7/31 (23%)
		CUB	591..700	CDD:278839	38/178 (21%)
		FXa_inhibition	707..742	CDD:291342	14/60 (23%)
		CUB	747..856	CDD:278839	68/301 (23%)
		CUB	860..973	CDD:278839
tpr	NP_611611.1	Tryp_SPc	126..354	CDD:214473	49/224 (22%)
tpr	NP_611611.1	Tryp_SPc	127..356	CDD:238113	48/223 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910