DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BMP1 and CG8170

DIOPT Version :9

Sequence 1:	NP_006120.1	Gene:	BMP1 / 649	HGNCID:	1067	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_610441.2	Gene:	CG8170 / 35908	FlyBaseID:	FBgn0033365	Length:	855	Species:	Drosophila melanogaster

Alignment Length:	719	Identity:	133/719 - (18%)
Similarity:	205/719 - (28%)	Gaps:	245/719 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   200 SIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVE--SLGE 262
            ::|...|....|.||.|                 ..:..:...|.|....|::.|:..|  .|..
  Fly   204 ALGPPADGVAAVAHEFG-----------------ADLATQGSGPEQPPLALELGPERTERSDLMA 251

Human   263 TYDFDSIMHYA--RNTFSR-------------------------GIFLDTIVPKYE-------VN 293
            .......:.||  .||..|                         .||.||....||       .:
  Fly   252 AASSTDKLEYAEPENTSRRVGFQFPSYSLKPASPFHPQAYREDNPIFGDTSAGGYEPQPYSEDAS 316

Human   294 GVKPPIGQRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYP---NGYSAHMHCVWRISVT 355
            .|.||    |:..:.:....|:||         .||....||.|:|   :....|...::|..||
  Fly   317 PVPPP----TQYEQHETRHTRQLY---------FDSDTASSSFEFPGLVSNSKPHGLKLYRDDVT 368

Human   356 PGEKIILNFTSLDLYR-SRLCWYDYVEVRDGFWRKAPLR----------------------GRFC 397
            ....|....|:|...| .|..::...|.|.|  ..||:|                      .|:.
  Fly   369 KFGDINGPITALPQQRPQRGFYFGDTEFRTG--PPAPVRQFGPQKNFQEYVGPSEYQGTRKSRYY 431

Human   398 ---GSKLPEPIVSTDSRLWVEFRS----SSNWVGKGF------------FAVYEAICGGDVKKDY 443
               .|:.|..:..|:..:.....|    ||...|.|.            |.:.|.....||:.||
  Fly   432 PYKSSRSPRVVFPTNDNVGTTGPSGPAGSSGPSGNGVYFSDNIAFRDQNFGINELAAVQDVRNDY 496

Human   444 GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSE------- 501
            . :|..:...:...|.      |.:..|.     :..:|.....|.:     |.|..|
  Fly   497 S-LQDLDSASEATSSP------QSASTFK-----EKVDITTDTECQH-----RGGTCEFFLGCWL 544

Human   502 SSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRG--GCEQRCL 564
            |..||...|     |.:.........|..:.||.:..|.||    ::.:..:.|.|  ..|..|.
  Fly   545 SGGLIQGTC-----DGLLRGCCHRTAKSANLGSSDFVGNAV----DLTDLPQKNYGPVNNEPSCG 600

Human   565 NTLGSYKC------SCDPGYELAPDK---RRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQ 620
            .:|.....      ..|.|:...|.:   |...:.|||.|......:|:          .:|:.:
  Fly   601 ISLAKQTAQRRIVGGDDAGFGSFPWQAYIRIGSSRCGGSLISRRHVVTA----------GHCVAR 655

Human   621 LVAPTQYRISLQFDFFETEGNDVCKYDF----VEVR--------------SGLTADSKLH----- 662
             ..|.|..::|......:....:..|.|    ::|.              |.||.:..:|
  Fly   656 -ATPRQVHVTLGDYVINSAVEPLPAYTFGVRRIDVHPYFKFTPQADRFDISVLTLERTVHFMPHI 719

Human   663 GKFCGSEKPEVITSQYN----------NMRVEFKS---------DNTVSKK-----GFKAHFFSD 703
            ...|..||.|....::.          ..|:..|:         :|.:.::     |.....:.:
  Fly   720 APICLPEKNEDFLGKFGWAAGWGALNPGSRLRPKTLQAVDVPVIENRICERWHRQNGINVVIYQE 784

Human   704 ----------KDECSKDNGGCQQDCVN--------TFGSYECQCRSGFVLHDNKHDCKEAGCDHK 750
                      ||.|..|:||......|        ....|.|..|.            :.|..|.
  Fly   785 MLCAGYRNGGKDSCQGDSGGPLMHDKNGRWYLIGVVSAGYSCASRG------------QPGIYHS 837

Human   751 VTST 754
            |:.|
  Fly   838 VSKT 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BMP1	NP_006120.1	ZnMc_BMP1_TLD	121..320	CDD:239808	30/155 (19%)
		Astacin	128..321	CDD:279708	30/156 (19%)
		CUB	322..431	CDD:278839	31/153 (20%)
		CUB	435..544	CDD:278839	24/115 (21%)
		FXa_inhibition	555..587	CDD:291342	9/42 (21%)
		CUB	591..700	CDD:278839	24/155 (15%)
		FXa_inhibition	707..742	CDD:291342	8/42 (19%)
		CUB	747..856	CDD:278839	3/8 (38%)
		CUB	860..973	CDD:278839
CG8170	NP_610441.2	Tryp_SPc	611..845	CDD:214473	42/254 (17%)
CG8170	NP_610441.2	Tryp_SPc	612..846	CDD:238113	42/253 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910